Sebaceous Carcinoma of the Face Following Irradiation

Hood, Ian C.; Qizilbash, Ali H.; Salama, Samih; Young, James K.; Archibald, Stuart

doi:10.1097/00000372-198612000-00009

Cited by 54 publications

(23 citation statements)

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“…106,107 Cutaneous lesions may be diagnosed before, after, or concurrently with malignancy in patients with MTS, so any sebaceous neoplasm, including SGC, should elicit a search for pertinent family history and for an associated underlying malignancy. [111][112][113] Earlyonset SGC has been associated with radiotherapy for retinoblastoma, although patients with hereditary retinoblastoma may have a high risk of SGC because this neoplasm has developed in the absence of irradiation in patients with hereditary retinoblastoma. [108][109][110] Radiation therapy of the head and neck for eczema, hemangioma, and epilation has been reported to increase the risk of periocular SGC.…”

Section: Sebaceous Gland Carcinomamentioning

confidence: 99%

“…[108][109][110] Radiation therapy of the head and neck for eczema, hemangioma, and epilation has been reported to increase the risk of periocular SGC. [111][112][113] Earlyonset SGC has been associated with radiotherapy for retinoblastoma, although patients with hereditary retinoblastoma may have a high risk of SGC because this neoplasm has developed in the absence of irradiation in patients with hereditary retinoblastoma. [114][115][116] SGC in any location is an aggressive malignancy, with risks of local recurrence and metastasis and overall mortality rates between 9% and 50%.…”

Section: Sebaceous Gland Carcinomamentioning

confidence: 99%

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Periocular Cutaneous Malignancies: A Review of the Literature

Slutsky

Jones

2012

Dermatologic Surgery

105

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Timely diagnosis and management of periocular malignancies is essential because of their proximity to and potential to invade vital structures such as the orbit, sinuses, and brain. Surgical excision remains the standard of care for the majority of periorbital malignancies, but given the sensitive anatomic location, tissue-sparing techniques with margin control such as Mohs micrographic surgery are the preferred method for most nonmelanoma skin cancers. Depending on tumor type, other treatment modalities may include radiation, chemotherapy, cryosurgery, topical medications, and photodynamic therapy.

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Section: Sebaceous Gland Carcinomamentioning

confidence: 99%

Section: Sebaceous Gland Carcinomamentioning

confidence: 99%

Periocular Cutaneous Malignancies: A Review of the Literature

Slutsky

Jones

2012

Dermatologic Surgery

105

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“…20 Occasionally, this tumor develops after irradiation therapy to the area. 7,[21][22][23][24] Ocular SC is described as more aggressive 18,25,26 with locoregional and/or distant metastasis and/or intracranial extension. [26][27][28] Fifteen percent to 30% of patients affected by ocular SC develop metastasis to the lymph nodes, with a 5-year death rate of 20% after the occurrence of metastasis.…”

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confidence: 99%

Biological Behavior of the Sebaceous Carcinoma of the Head

et al. 2004

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“…Irradiation is also a significant risk factor. There have been multiple reports of SC presenting within the field of irradiation for treatment of other neoplastic conditions such as retinoblastoma or for benign conditions such as eczema or cosmetic epilation (37–40).…”

Section: Incidence and Risk Factorsmentioning

confidence: 99%

Sebaceous carcinoma: the great masquerader

Buitrago

Joseph²

2008

Dermatologic Therapy

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Sebaceous carcinoma (SC) is a rare tumor with a high rate of local recurrence and metastasis to lymph nodes and organs. The majority of SCs occur in the periocular region frequently presenting as painless, round subcutaneous nodules with a high tendency of diffuse and invasive growth in the eyelid and conjunctiva. It frequently masquerades as inflammatory conditions or as other tumors leading to delay in diagnosis, inappropriate treatment and increased morbidity and mortality. Sebaceous carcinoma is associated with Muir-Torre syndrome, a genetic condition presenting with sebaceous skin tumors associated with internal malignancy. Therefore, SC patients must be carefully evaluated and referred to an internist or gastroenterologist when indicated. Surgery is the definitive therapy for SC. In recent years, less radical surgical strategies are being used with improved outcomes. Current studies demonstrate that Mohs micrographic surgery (MMS) provides maximal tissue conservation and lower recurrence rates. Greater awareness and understanding of SC and its behavior has led to earlier diagnosis and appropriate treatment.

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Sebaceous Carcinoma of the Face Following Irradiation

Cited by 54 publications

References 0 publications

Periocular Cutaneous Malignancies: A Review of the Literature

Periocular Cutaneous Malignancies: A Review of the Literature

Biological Behavior of the Sebaceous Carcinoma of the Head

Sebaceous carcinoma: the great masquerader

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