Sebaceous Carcinoma of the Ocular Region: A Review

Shields, Jerry A.; Demirci, Hakan; Marr, Brian P.; Eagle, Ralph C.; Shields, Carol L.

doi:10.1016/j.survophthal.2004.12.008

Cited by 331 publications

(451 citation statements)

References 140 publications

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“…Most case reports of sebaceous carcinoma demonstrate that women are more likely to develop this cutaneous malignancy, and 1 major review stated that >70% of cases occur in women. 1,[7][8][9][10] Our data are more supportive of other studies, which reported a relatively equal predisposition for the development of sebaceous carcinoma in men and women. OR indicates odds ratio; CI, confidence interval.…”

Section: (344)supporting

confidence: 88%

“…1 The work cited most to support an Asian predominance is the article by Ni et al, 7 in which the incidence of sebaceous carcinoma in Shanghai is compared with that in Boston. Ni et al observed that sebaceous cell carcinomas accounted for 32.7% of malignant eyelid tumors in Shanghai; whereas, at the Massachusetts Eye and Ear Institute, sebaceous carcinomas accounted for only 1.5% of eyelid tumors.…”

Section: (344)mentioning

confidence: 99%

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A retrospective review of 1349 cases of sebaceous carcinoma

Dasgupta

Wilson

2008

Cancer

327

294

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BACKGROUD:Sebaceous carcinoma is a rare and aggressive cutaneous carcinoma. It is believed that this malignancy predominates in the periocular region and occurs more frequently in Asian populations and in women. The objective of the current study was to analyze demographic characteristics and outcomes for patients with this malignancy from a large United States‐based population registry.METHODS:An analysis of the National Cancer Institute's Surveillance, Epidemiology, and End Results database from 1973 through 2004 was performed.RESULTS:Of 1349 patients who were identified, 54% were men, 86.2% were white, and 5.5% were of Asian/Pacific Islander ancestry. The median age at diagnosis was 73 years. The most frequent site of disease was the eyelid (38.7%). The population‐matched 5‐ and 10‐year age‐matched relative survival rate was 91.9% (standard error [SE], 1.9%) and 79.2% (SE, 3.7%), respectively. Cause of death was attributable to cancer in 31% of patients. Orbital involvement did not predict for worsened survival compared with nonorbital involvement (5‐year overall survival, 75.2% vs 68%, respectively; P = .66). The overall population‐matched rate of sebaceous carcinoma was highest in whites (2.03 cases per 1000,000; SE, 0.08) versus Asian/Pacific Islanders (1.07 per 1000,000; SE, 0.18; P = .0001) versus blacks (0.48 per 1000,000; SE, 0.11; P < .0001).CONCLUSIONS:The current results support the finding of a predominance of men among patients with sebaceous carcinoma, and no difference was observed in the prognosis for orbital and periorbital involvement. This retrospective analysis also corroborated previous case reports of a higher incidence among patients with advanced age and the highest incidence for sites in the eyelid and skin of the face. The results also established that Asian/Pacific Islander ancestry is not a risk factor for developing sebaceous carcinoma. Cancer 2009. © 2008 American Cancer Society.

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Section: (344)supporting

confidence: 88%

Section: (344)mentioning

confidence: 99%

A retrospective review of 1349 cases of sebaceous carcinoma

Dasgupta

Wilson

2008

Cancer

327

294

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“…Keywords: adipophilin; sebaceous tumors; differential diagnosis Sebaceous carcinoma is a relatively uncommon tumor comprising 0.05% of all cutaneous malignancies, but is the second or third most common malignant eyelid tumor in most series accounting for 2-4% of periocular tumors. 1 Local recurrence complicates 6-29% of periocular sebaceous cell carcinomas. [2][3][4][5] Regional or distal metastases affect 14-25% of patients with an associated 5-year mortality ranging from 30 to 67% according to different reports.…”

mentioning

confidence: 99%

Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases

et al. 2010

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Adipophilin is a monoclonal antibody against a protein on the surface of intracellular lipid droplets, and it was recently shown to be expressed in sebocytes and sebaceous lesions. This study examines adipophilin expression in various sebaceous lesions and other cutaneous tumors with a clear cell histology that may mimic sebaceous differentiation. A total of 117 cutaneous clear cell lesions including 16 sebaceous adenomas, 25 sebaceous carcinomas, 8 basal cell carcinomas, 12 squamous cell carcinomas, 6 xanthomas, 10 xanthelasmas, 10 xanthogranulomas, 4 balloon cell nevi, 5 trichilemmomas, 8 clear cell hidradenomas, and 13 metastatic renal cell carcinomas were examined using immunohistochemistry for the expression of adipophilin. Of these 117 lesions, 42 (36%) were from the periocular region. Adipophilin was expressed in 16 of 16 (100%) sebaceous adenomas, 23 of 25 (92%) sebaceous carcinomas, 10 of 10 (100%) xanthelasmas, 9 of 10 (90%) xanthogranulomas, 6 of 6 (100%) xanthomas, and 9 of 13 (62.5%) metastatic renal cell carcinomas. The characteristic staining pattern differed between sebaceous and non-sebaceous tumors with the former showing a membranous vesicular pattern and the latter being more granular. Adipophilin expression was not seen in any of the other lesions with clear cell histology, basal cell carcinomas, or squamous cell carcinomas, including cases that had focal clear cell differentiation. Adipophilin can be valuable in an immunohistochemical panel when evaluating cutaneous lesions with clear cell histology as it identifies intracytoplasmic lipid vesicles in sebaceous and xanthomatous lesions. In periocular lesions, it is effective in helping to exclude basal cell carcinoma and squamous cell carcinoma when sebaceous carcinoma is under consideration. Adipophilin expression is not as useful for the differential diagnosis that includes metastatic renal cell carcinoma, a rare but important, diagnostic differential. The pattern of adipophilin reactivity is important to observe as membranous vesicular staining is suggestive of intracellular lipids whereas granular cytoplasmic reactivity is not. Modern Pathology (2010) 23, 567-573; doi:10.1038/modpathol.2010.1; published online 29 January 2010Keywords: adipophilin; sebaceous tumors; differential diagnosis Sebaceous carcinoma is a relatively uncommon tumor comprising 0.05% of all cutaneous malignancies, but is the second or third most common malignant eyelid tumor in most series accounting for 2-4% of periocular tumors. 1 Local recurrence complicates 6-29% of periocular sebaceous cell carcinomas. [2][3][4][5] Regional or distal metastases affect 14-25% of patients with an associated 5-year mortality ranging from 30 to 67% according to different reports. 2,4 Owing to its variable clinical appearance, sebaceous carcinoma mimics both benign processes, such as chalazions and blepharitis, and other malignant

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“…The available literature on treatment recommends wide surgical excision with tumour-free margins, followed by adjuvant radiotherapy 4 . No study has looked at the pattern of metastatic disease sites and the choice of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…It is not clear if the rate of distant metastasis and recurrence is more common in the periocular type of sebaceous carcinoma 3 . Wide excision with negative margins and selective use of radiotherapy is the treatment of choice in localized tumours 4 . Being rare, distant metastasis has little reported experience about the efficacy of chemotherapy in its treatment.…”

Section: Introductionmentioning

confidence: 99%

Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours?

Kumar

2015

Current Oncology

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Sebaceous carcinoma is a rare malignant tumour of skin. It commonly occurs in the head and neck region. The standard of care for localized disease is wide local excision followed by radiotherapy. Occasionally, sebaceous carcinoma can be associated with Muir-Torre syndrome, which is characterized by sebaceous lesions and carcinomas in the visceral organs. Metastatic sebaceous carcinoma is even rarer, with very little evidence about the role of chemotherapy in the treatment of metastatic disease.Here, we report a case of recurrent sebaceous carcinoma metastatic to the rectum (initially mimicking rectal cancer and Muir-Torre syndrome) in which the disease responded to multiple lines of chemotherapy. We also review the available literature on chemotherapy in this disease and discuss the role of tumour profiling and genotypeguided selection of chemotherapeutics in such rare tumours.

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Sebaceous Carcinoma of the Ocular Region: A Review

Cited by 331 publications

References 140 publications

A retrospective review of 1349 cases of sebaceous carcinoma

A retrospective review of 1349 cases of sebaceous carcinoma

Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases

Unusual Presentation of Metastatic Sebaceous Crcinoma and Its Response to Chemotherapy: Is Genotyping a Right Answer for Guiding Chemotherapy in Rare Tumours?

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