Sebaceous differentiation in a breast carcinoma with ductal, myoepithelial and squamous elements

Abstract

documents the recurrence of a lesion with the features of giant cell fibroblastoma 3 years after the local excision of a dermatofibrosarcoma protuberans and, while supporting their close relationship, suggests that their different morphological manifestations are not simply age related. Case reportA 17-year-old male was noted to have a mass present in the left groin for several months. This was excised at another hospital. At age 20, he underwent re-excision of a recurrent tumour from the same region. PATHOLOGICAL FINDINGSThe flrst specimen was described as a skin ellipse 4 x 1.5 cm with a 0.7 cm nodule located within the dermis.

Sebaceous carcinoma of the breast: case report and review of the literature

“…Based on the clinicopathologic findings, the current tumor is analogous to those previously reported as mammary carcinoma with sebaceous differentiation or sebaceous carcinoma of the breast [6,7,12,15,16]. As the initial identification as a variant of lipid-secreting carcinoma [15], sebaceous differentiation has been rarely described in variable morphologic types of mammary carcinoma, such as infiltrating (or invasive) ductal carcinoma, adenoid cystic carcinoma, and a carcinoma with ductal, myoepithelial and squamous elements [6,7,12,14,16].…”

“…As the initial identification as a variant of lipid-secreting carcinoma [15], sebaceous differentiation has been rarely described in variable morphologic types of mammary carcinoma, such as infiltrating (or invasive) ductal carcinoma, adenoid cystic carcinoma, and a carcinoma with ductal, myoepithelial and squamous elements [6,7,12,14,16]. In addition, a single case of sebaceous gland metaplasia in intraductal papilloma has been recently described [3].…”

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

“…A few cases of invasive ductal carcinoma with a minor sebaceous component (i.e. < 50%) have also been described [2,10,11]. Moreover, sebaceous differentiation rarely occurs in other malignant and benign mammary lesions: adenoid cystic carcinoma [13], cylindroma [14], adenomyoepithelioma [15,16] or intraductal papilloma [17].…”

“…It has been described in 15 cases so far in the English-language literature, either as a minor or predominant component in a classical ductal carcinoma or as a pure line of differentiation [1][2][3][4][5][6][7][8][9][10][11]. According to the current WHO classification, primary sebaceous carcinoma of the breast must show sebaceous differentiation in at least 50% of cells and have no evidence of origin from the cutaneous adnexa [12].…”

Mammary adenoma with sebaceous differentiation in a dog

“…Squamous metaplasia is suggested to be associated with sebaceous differentiation in human mammary tumors. 2,9,11,13 Furthermore, canine squamous metaplasia has not been reported to be accompanied by sebaceous differentiation in a case of mammary carcinoma. 3 In the current case, the squamous epithelium was partially continuous with a sebaceous structure, indicating close association between these 2 components.…”