Sebaceous gland atrophy in seborrheic dermatitis of the scalp; a pilot study

Nagrani, Neha S.; Goldberg, Lynne J.

doi:10.1111/cup.14300

Cited by 4 publications

(9 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors noted significantly smaller sebaceous lobule size in patients with seborrheic dermatitis compared to other, non-psoriatic inflammatory dermatoses. 10 No patients had a reported history of hair loss; however, two of the six cases evaluated in their series also displayed histological findings compatible with AGA. The authors proposed the idea that "psoriatic alopecia" may reflect a reaction pattern that is not solely confined to psoriasis.…”

Section: Discussionmentioning

confidence: 88%

“…4,5,11 Sebaceous gland atrophy has been defined as a decrease in sebaceous gland size coupled with a decrease in lipidized sebocytes. 10 Sebaceous gland atrophy in psoriasis was first described in a study of cutaneous psoriatic plaques from the scalp. 4 The authors suggested that the atrophic process was reversible as basaloid sebaceous epithelium persisted even in extreme stages of sebaceous gland atrophy, and hypothesized sebaceous gland atrophy was attributed to epidermal growth factor or transforming growth factor-α effects.…”

Section: Discussionmentioning

confidence: 99%

“…The authors proposed the idea that "psoriatic alopecia" may reflect a reaction pattern that is not solely confined to psoriasis. 10 AGA is a multifactorial disease driven by androgenic stimulation and genetic influences. It can affect both males (male pattern hair loss) and females (female pattern hair loss).…”

Section: Discussionmentioning

confidence: 99%

“…4 A number of studies have concurred that sebaceous gland atrophy is a relatively specific clue to the presence of psoriasis and psoriatic alopecia [5][6][7] ; however, it has also been reported in facial discoid dermatitis, 2 drug-induced alopecia, 8,9 and more recently in seborrheic dermatitis. 10 These observations have prompted the idea that sebaceous gland atrophy might not be as specific in scalp biopsies and could occur in other alopetic processes. In our case, we suggest that in patients with seborrheic dermatitis, prominent sebaceous gland atrophy should be recognized as a pitfall as it may complicate the evaluation of alopecia biopsy specimens.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall

Zengin,

Guthrie,

Zoumberos

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

Seborrheic dermatitis is an inflammatory condition that usually presents with erythema, scaly greasy papules, and plaques affecting sebaceous gland‐rich areas and predominantly involving the face and scalp. The diagnosis of seborrheic dermatitis can often be rendered based on the clinical presentation. However, in certain cases, a biopsy can be useful to distinguish it from clinical mimics such as psoriasis, discoid lupus, and rosacea. Prominent sebaceous gland atrophy without scarring has been well‐described as an important and relatively specific clue for psoriatic or drug‐induced alopecia. However, sebaceous gland atrophy is not specific to psoriasis and has been demonstrated in seborrheic dermatitis, facial discoid dermatitis, and potentially may occur in other inflammatory dermatoses of the scalp. We report a 23‐year‐old female patient presenting with non‐scarring hair loss and histopathological findings demonstrating mild androgenetic alopecia and changes of seborrheic dermatitis with dramatic sebaceous gland atrophy. The patient had no history or evidence of psoriasis clinically. Our case suggests that in patients with seborrheic dermatitis, sebaceous gland atrophy may complicate the evaluation of alopecia biopsies and should be recognized as a pitfall. Seborrheic dermatitis should be included in the differential diagnosis of alopecia biopsies showing prominent sebaceous gland atrophy.

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall

Zengin,

Guthrie,

Zoumberos

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“… 71 , 72 Studies have shown that age-related changes also result in sebaceous gland atrophy and skin diseases such as psoriasis and dermatitis. 73 – 75 A recent study using comprehensive lipidomic analysis of meibum, sebum, and tears of a patient with abnormal meibomian and sebaceous gland secretions reported altered composition in various lipid classes in meibum, as well as sebum. 76 Changes in the lipid composition of sebum, as well as meibum, could be important in ocular surface disease, because sebaceous gland secretions may also be incorporated into the tear film.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis

Nagar,

Ajouz,

Nichols

et al. 2023

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose Information on the relationship between meibum lipid composition and severity of meibomian gland dysfunction (MGD) is limited. The purpose of this study was to analyze the molecular components of meibum collected from individuals with no MGD, mild-to-moderate MGD, and severe MGD. Methods Adults with and without MGD were enrolled in a prospective, multicenter, exploratory clinical trial (ClinicalTrials.gov Identifier: NCT01979887). Molar ratios of cholesteryl ester to wax ester (R CE/WE ) and aldehyde to wax ester (R ald/WE ) in meibum samples were measured with 1 H-NMR spectroscopy. Results were evaluated for participants grouped by MGD disease status and severity (non-MGD, mild-to-moderate MGD, and severe MGD), as defined by maximum meibum quality scores, Schirmer test results, and Subject Ocular Symptom Questionnaire responses. Results Sixty-nine meibum samples from 69 individuals were included in the analysis: 24 non-MGD, 24 mild-to-moderate MGD, and 21 severe MGD. Mean R CE/WE was 0.29 in non-MGD, 0.14 in mild-to-moderate MGD ( P = 0.038 vs. non-MGD, 51% lower), and 0.07 in severe MGD ( P = 0.16 vs. mild-to-moderate MGD, 52% lower; P = 0.002 vs. non-MGD, 76% lower). Mean R ald/WE was 0.00022 in non-MGD, 0.00083 in mild-to-moderate MGD ( P = 0.07 vs. non-MGD, 277% higher), and 0.0024 in severe MGD ( P = 0.003 vs. mild-to-moderate MGD, 190% higher; P < 0.001 vs. non-MGD, 992% higher). Conclusions R CE/WE was lowest and R ald/WE was highest in the severe MGD cohort, suggesting that these meibum constituent molar ratios may result from the pathophysiology associated with MGD and can impact ocular surface lipid and tear film homeostasis. These findings may potentially help identify targets for MGD treatment.

show abstract

Seborrheic Dermatitis: From Microbiome and Skin Barrier Involvement to Emerging Approaches in Dermocosmetic Treatment

Galizia,

Belloni Fortina,

Semenzato

2024

Cosmetics

View full text Add to dashboard Cite

Seborrheic dermatitis (SD) is a chronic inflammatory skin disease that primarily affects sebaceous-rich areas such as the scalp, face, and upper trunk. While the precise etiology remains multifactorial, the role of the skin microbiome, particularly the proliferation of Malassezia species, and alterations in the skin barrier function are critical in its pathogenesis. Disruption of the skin barrier, characterized by increased transepidermal water loss (TEWL) and reduced production of epidermal lipids, creates a favorable environment for microbial overgrowth and inflammation. Recent insights highlight the interplay between the impaired barrier function, immune responses, and the skin microbiome in perpetuating the disease. Additionally, novel dermocosmetic approaches are emerging that target these underlying mechanisms, offering promising therapeutic avenues. This review provides a comprehensive overview of the involvement of skin microbiome and barrier dysfunction in seborrheic dermatitis and discusses the potential of advanced dermocosmetic treatments aimed at restoring skin homeostasis and preventing disease recurrence.

show abstract

Sebaceous gland atrophy in seborrheic dermatitis of the scalp; a pilot study

Cited by 4 publications

References 19 publications

Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall

Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall

Relationship Between Human Meibum Lipid Composition and the Severity of Meibomian Gland Dysfunction: A Spectroscopic Analysis

Seborrheic Dermatitis: From Microbiome and Skin Barrier Involvement to Emerging Approaches in Dermocosmetic Treatment

Contact Info

Product

Resources

About