Sebaceous Gland Carcinoma

Doxanas, Marcos T.

doi:10.1001/archopht.1984.01040030195025

Cited by 270 publications

(210 citation statements)

References 17 publications

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“…1,2 The predominance of BCC in the lower eyelid was shown in various studies 2,4,12,13,15 as well as in our study. However, more SGCs occurred in the upper eyelid in various studies 7,8,16,17 and in this study. In most series, the upper eyelid is involved two to three times more frequently than the lower lid for SGC.…”

Section: Sgccontrasting

confidence: 47%

Malignant eyelid tumours in Taiwan

Wang

Liao

Jou

et al. 2003

Eye

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Aims To describe the clinical characteristics of patients with eyelid cancers in Taiwan. Methods Between 1980 and 2000, 127 (58 males and 69 females) patients (mean age 62.6; range 10-91 years) with histologically confirmed eyelid cancers were retrospectively evaluated at the National Taiwan University Hospital and Far Eastern Memorial Hospital in Taiwan. Clinical data of all patients were reviewed from medical records. The mean follow-up period was 62.4 months (range 3-240) for 113 patients. Results The 127 eyelid cancers included 79 basal cell carcinomas (62.2%), 30 sebaceous gland carcinomas (23.6%), 11 squamous cell carcinomas (8.7%), five malignant melanomas (3.9%), one Kaposi's sarcoma (0.8%), and one metastatic cancer (0.8%). Tumours developed more commonly in the lower (37.0%) than the upper eyelid (33.9%). The clinical accuracy in predicting eyelid malignancy was 90.5%. Primary treatment modality was mainly surgical excision. The recurrence, metastasis, and mortality rates at 5 years were 15.2, 11.7, and 7.3%, respectively, for all eyelid malignancies. Rates of sebaceous gland carcinoma recurrence, metastasis, and mortality were significantly higher (Po0.05) than those of basal cell carcinoma. The mean interval of recurrence or metastasis after primary treatment was 26.3 months (range 4-112) for all eyelid cancers. Conclusions Although basal cell carcinoma is the most common eyelid cancer in Taiwan, sebaceous gland carcinoma is also common. Of the two, basal cell carcinoma has a better prognosis and sebaceous gland carcinoma has a higher mortality and therefore should be treated much more aggressively. Long-term follow-up is needed after treatment of malignant eyelid tumours.

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Section: Sgccontrasting

confidence: 47%

Malignant eyelid tumours in Taiwan

Wang

Liao

Jou

et al. 2003

Eye

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“…The incidence of all skin malignancy is increasing worldwide. [11][12][13][14][15][16] Basal cell and squamous cell carcinoma occur most commonly in the lower lid and medial canthus. 9,17,18 Sebaceous gland carcinoma is most common in the upper lid.…”

Section: Indicationsmentioning

confidence: 99%

Orbital exenteration for invasive skin tumours

Tyers

2006

Eye

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Orbital exenteration aims at local control of disease invading the orbit that is potentially fatal or relentlessly progressive. Of all exenterations presenting to ophthalmologists, 40-50% are required for tumours in the eyelid or periocular skin. 99% of these are basal cell carcinomas and 4-6% each are squamous cell carcinomas or sebaceous gland carcinomas. Orbital invasion results in progressive fixation of the tumour to bone and reduced ocular motility. Perineural invasion of branches of the trigeminal nerve leads to numbness or pain, and that the facial nerve, to weakness. Biopsy identifies the cell type and the presence of perineural invasion. CT and MRI scanning help in the assessment of tumour spread within the orbit. Management should be in collaboration with an oncologist. Exenteration may be totalthe removal of all orbital contents-or lidsparing if the tumour is placed posteriorly. The socket may be allowed to heal by granulation or lined with a split skin graft or local flap. Complications may be seen following 20-25% of exenterations and include fistulae, tissue necrosis, exposed bone, and infection. Incomplete clearance of tumours occurs in about 38% of total exenterations and 17% of subtotal. The overall 5-year survival is 55-65%, but significantly worse if there was perineural spread. Facial prostheses may be mounted on glasses or secured with tissue glue or osseointegrated implants. Excellent cosmetic results can be achieved but many patients prefer to wear a patch.

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“…The report incidence ranges from 1 to 5.5% of the malignant eyelid tumours. 1 We report a case of intraepithelial sebaceous gland carcinoma masquerading as marginal keratitis with extensive intraepithelial involvement of conjunctiva and the skin.…”

Section: Sirmentioning

confidence: 98%