Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Seborrheic keratosis is the most common benign tumor of the epidermis. Rarely the tumor develops in the perineal area and quite rarely is large. For the Leser-Trelat syndrome these tumors is a marker of a malignant disease even before the symptoms are appeared, as well as a manifestation of the paraneoplastic process. In our case report, a giant perianal seborrheic keratoma was the reason for the clinical examination of the patient and stomach cancer was detected. As a result, we demonstrated a successful experience of surgical treatment of seborrheic keratoma of the perianal area and determined an algorithm for the treatment of stomach cancer.
Seborrheic keratosis is the most common benign tumor of the epidermis. Rarely the tumor develops in the perineal area and quite rarely is large. For the Leser-Trelat syndrome these tumors is a marker of a malignant disease even before the symptoms are appeared, as well as a manifestation of the paraneoplastic process. In our case report, a giant perianal seborrheic keratoma was the reason for the clinical examination of the patient and stomach cancer was detected. As a result, we demonstrated a successful experience of surgical treatment of seborrheic keratoma of the perianal area and determined an algorithm for the treatment of stomach cancer.
The purpose of the study was to determine the effect of ultraviolet radiation on the risk of seborrheic keratosіs, assessing the level of correlation between anamnestic and clinical data (skin phototype, frequency of sunscreens) and the extent of neoplasms on the skin. Materials and methods. Sixty patients with seborrheic keratosіs were examined on the basis of "University clinic" of Zaporizhzhia State Medical University. Preliminary verification of the diagnosis was performed using visual examination, dermatoscopic examination based on a three-point algorithm in polarized light mode (FotoFinder Bodystudio ATBM (Germany). Clinical examination also included Fitzpatrick assessment of skin phototype, taking into account skin color, eye, hair color, and tendency to form tanning or its complications (burns). Results and discussion. Majority of patients were of II skin phototype – 40 (66.7%) individuals, III – 19 (31.7%), IV – 1 (1.7%). 37 patients (61.6%) with seborrheic keratosіs received skin burns after prolonged exposure to the open sun. The most frequent localizations of keratoma were areas of the head – 23 (38.33%) patients, torso – 17 (28.33%), limbs – 16 (26.67%), neck – 4 (6.67%). Thus, taking into account the areas of maximum ultraviolet exposure – head + neck + limbs – we have the majority of cases (n = 43 (71.7%)) with a possible risk factor in the form of increased insolation on these areas of skin. Only 1 patient lived in a country with increased insolation for 0.5 years. 29 (48.4%) patients never used sunscreens, 19 (31.6%) used them occasionally, and 12 (20%) always used them. Pearson's coefficient (Kp =0.51) and Chuprov's coefficient (Kh =0.50) indicate a moderate relationship between the number of foci and Fitzpatrick skin phototype. The data obtained do not rule out an association between the level of lesion foci dissemination and skin features to the perception of tanning. The association coefficient was 0.714 and the contingency coefficient was 0.4. Consequently, this suggests that the association between the use/non-use of sunscreen and the multiplicity of keratosis foci is significant. These data have not been highlighted in previous studies, so we believe that this is an additional argument for the mandatory use of sunscreen. Regular use of sunscreeens has really a significant protective potential for the occurrence of new skin formations, as well as their clinical dissemination. Conclusion. Ultraviolet radiation may be a predictor of multiple foci of keratosis. It is important to comprehensively examine patients with seborrheic keratosіs, focusing on evaluation of skin phototype, history of outdoor exposure, and sunbathing habits. The use of sunscreen remains the unequivocal leader in the prevention of multiple seborrheic keratosis
The aim is to identify age, gender, clinical and morphological features of seborrheic keratosis. Material and methods: The study used biopsy material from 196 patients with a clinical diagnosis of “Seborrheic keratosis”. In all cases, when studying directions for pathohistological examination, the authors analyzed gender and age characteristics, as well as localization of seborrheic keratosis. The resulting material was fixed in a 10% solution of neutral formalin (ph 7.4) for 24-48 hours. The procedure was carried out according to the generally accepted technique and the material was embedded in paraffin. Sections of 4–5×10–6m thick were made from paraffin blocks for staining with hematoxylin and eosin. The microspecimens were examined using an Olympus BX-41 microscope (Japan). Results: The study revealed a modern feature of seborrheic keratosis –”rejuvenation” of this tumor, as evidenced by its predominant development in patients aged 31 to 50 years. Seborrheic keratosis is more common in men, and is localized mainly on the skin of the face, scalp, neck and back. When diagnosing seborrheic keratosis, the author notes a significant discrepancy between clinical and morphological diagnoses, which actualizes the problem of improving the available clinical research methods and emphasizes the importance of morphological research. Hyperkeratotic and acanthotic histological variants of seborrheic keratosis are the most common. The case of seborrheic keratosis with malignancy and transformation into squamous cell carcinoma, identified by the author, should develop oncological alertness in doctors and patients. Conclusions: The study revealed age, gender, clinical and morphological features of seborrheic keratosis, which will contribute to a better understanding of this pathology by the doctors of various specialties, and improve the treatment and diagnostic process.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.