Seborrheic keratosis

Abstract

Summary Seborrheic keratosis (SK) is the most common benign epidermal tumor in clinical dermatological practice. This review summarizes current knowledge about the clinical and histological appearance, epidemiology, pathogenesis, and treatment of SK. There are different subtypes of SK based on clinical presentation and histologic findings. Several factors, including age, genetic predisposition, and possibly also exposure to ultraviolet radiation, are thought to contribute to the development of SK. The lesions can occur on all areas of the body except for the palms and soles, but the most common sites are the face and upper trunk. The diagnosis is usually made clinically, and in some cases by dermatoscopy or histology. Many patients prefer to have the lesions removed for cosmetic reasons although there is no medical indication. Treatment options include surgical therapy, laser therapy, electrocautery, cryotherapy, and topical drug therapy, which is currently in development. Treatment should be individualized depending on the clinical picture and patient preference.

Tumor of follicular infundibulum – reappraisal in a series of 28 patients with critical review of the literature

“…With respect to molecular investigations, mutations in the AKT-signaling pathway and in epidermal fibroblast growth factor receptor 3 (FGFR3) seem to play a pathogenetic role in the development of SK. 37 Apart from solitary TFI resembling SK, the data presented in Table 1 and 2 confirm that TFI features are commonly associated with other lesions ranging from hamartomas, F I G U R E 9 Numerous irregular lesions over anterior aspect of chest that have failed to tan (1). Irregular shapes and indistinct margins of eruptive infundibulomas (2).…”

“…Thus, different parts of the hair follicle may develop in varying forms of keratoses and trichogenic lesions. With respect to molecular investigations, mutations in the AKT‐signaling pathway and in epidermal fibroblast growth factor receptor 3 (FGFR3) seem to play a pathogenetic role in the development of SK 37 …”

A case of seborrheic keratosis lesions localized to eyebrow tattoos

“…In clinical dermatological practice, SK can occur on all hair-bearing areas of the body, but the most common sites of the lesions are the face and upper trunk. 1 Herein, we report a case of multiple SKs on both eyebrows secondary to eyebrow tattoos in a 30-year-old immunocompetent Chinese woman with a 3-year history. Physical examination revealed multiple clusters of keratotic papules and plaques on her bilateral eyebrows (Figure 1).…”

Tumor des follikulären Infundibulums – Neubewertung in einer Serie von 28 Patienten mit kritischer Analyse der Literatur

“…Im Hinblick auf molekulare Untersuchungen scheinen Mutationen im AKT-Signalweg und im Fibroblasten Wachstumsfaktor 3 (FGFR3) in der Epidermis eine pathogenetische Rolle bei der Entstehung von SK zu spielen. 37 Abgesehen von solitären TFI, die seborrhoischen Keratosen ähneln können, bestätigen unsere Daten von Tabelle 1 und 2, dass TFI-ähnliche Veränderungen in unterschiedlichen Läsionen vorkommen können, Hamartome, inflammatorische, infektiöse, reaktive Prozesse bis hin zu Neoplasien. Insbesondere wurde TFI in Assoziation mit einem Basalzellkarzinom, 3,11,12,21,22,24,38 aktinischer Keratose/SCC, 3,12,21,22,24 benignen und malignen melanozytären Läsionen, 3,12,23,24 seborrhoischer Keratose, Trichilemmom, Trichoblastom, Syringom, Syringozystadenoma papilliferum, Hidrocystom, adenosquamöses Karzinom, Nävus sebaceus und anderen beschrieben, 11,12,24,[39][40][41] wie von Dempsey und Mitarbeitern zusammengefasst.…”