Seborrhoeic keratoses in patients with internal malignancies: a case–control study with prospective accrual of patients

Am, Fink; Filz, D; Krajnik, G.; Jurecka, W; Ludwig, Heinz; Steiner, Andreas

doi:10.1111/j.1468-3083.2009.03163.x

Cited by 19 publications

(21 citation statements)

References 12 publications

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“…Critics advocate that in the elderly both seborrheic keratoses and cancer are common and their coexistence may be fortuitous [18, 19]. Lindelöf et al have evaluated the possible association of malignant disease and the sign in 1752 consecutive cases of seborrheic keratoses and found no evidence to support the validity of the Leser-Trélat sign.…”

Section: Discussionmentioning

confidence: 99%

“…Howsoever, men with seborrheic keratoses appeared to have a slightly increased risk of urinary tract neoplasia, excluding kidney (RR 2.2, IC 1.2–3.8), and women, tendency of breast cancer (RR 1.6, IC 1.1–2.2) [20]. Fink et al counted the number and sites of seborrheic keratoses in 150 oncological patients and 150 matched controls; no association was found between these cutaneous findings and cancer [19]. …”

Section: Discussionmentioning

confidence: 99%

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Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer

Stollmeier

Rosario

Mayer

et al. 2016

Case Reports in Medicine

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Introduction. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Although rarely observed, the sudden appearance and/or rapid increase in number and size of seborrheic keratoses can be associated with malignant neoplasms, known as the sign of Leser-Trélat. The aim of this report is to unveil a case of a patient whose recently erupted seborrheic keratoses led to investigation and consequent diagnosis of bladder cancer. Case Presentation. A 67-year-old man was admitted to the intensive care unit due to an exacerbation of chronic obstructive pulmonary disease (COPD). On physical examination, multiple seborrheic keratoses on the back of the hands, elbows, and trunk were observed; the patient had a 4-month history of these lesions yet was asymptomatic. The possibility of Leser-Trélat syndrome justified the investigation for neoplasia, and a bladder carcinoma was detected by CT-scan. The patient denied previous hematuria or any other related symptoms. Many of the lesions regressed during oncologic treatment. Conclusion. Despite the critics on the validity of the sign of Leser-Trélat, our patient fulfills the description of the disease, though urinary malignancy is a rare association. That corroborates the need of further investigation when there is a possibility of paraneoplastic manifestation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer

Stollmeier

Rosario

Mayer

et al. 2016

Case Reports in Medicine

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“…Öte yandan bu belirtinin paraneoplastik bir sendroma işaret ettiği halen tartışmalıdır. Birçok hastanın yaşlı, dolayısıyla hem seboreik keratoz hem de malinite gelişimi açısından uygun yaşta olduğunun göz önünde bulundurulması gerektiği belirtilmiştir 1,3 . Bu belirtinin sadece hasta öyküsüne dayalı olup, varlığını ispat edecek objektif bulguların çoğu zaman eksik olduğuna dikkat çekilmiştir.…”

Section: Seboreik Keratozunclassified

“…Bu belirtinin sadece hasta öyküsüne dayalı olup, varlığını ispat edecek objektif bulguların çoğu zaman eksik olduğuna dikkat çekilmiştir. Özellikle yaşlı hastalarda bu yönde anamnezin çok güvenilir olmayacağı da öne sürülmüştür 1,3 . İnternal malinitesi olan hastalarda seboreik keratoz sayısı ve Leser-Trélat belirtisinin varlığını araştıran kontrollü bir çalışmada, kontrol grubu ve kanser hastaları arasında seboreik keratozların sayıca ve yerleşim olarak farklılık göstermediği bulunmuştur.…”

Section: Seboreik Keratozunclassified

“…İnternal malinitesi olan hastalarda seboreik keratoz sayısı ve Leser-Trélat belirtisinin varlığını araştıran kontrollü bir çalışmada, kontrol grubu ve kanser hastaları arasında seboreik keratozların sayıca ve yerleşim olarak farklılık göstermediği bulunmuştur. Dolayısıyla, bu belirtinin altta yatan malinite için kutane bir belirteç olabileceği kanıtlanamamıştır 3 . Öte yandan, erüptif seboreik keratozların malinitesi olmayan hastalarda da görülebileceğine dikkat çekilmiştir (psödo-Leser-Trélat belirtisi) 2 .…”

Section: Seboreik Keratozunclassified

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Selim deri tümörleri ve sistemik malinite ilişkisi

Yazganoğlu¹,

Baykal²

2013

TURKDERM

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ÖzetDerinin karmaşık histolojik görüntüsü ile ilişkili olarak çok sayıda selim deri tümörü tipi vardır. Bunlardan az bir bölümü sistemik maliniteler ile ilişki gösterebilir. Bu makalede sistemik maliniteler ile ilişkisi iyi bilinen veya tartışmalı olan selim deri tümörlerinden bahsedilecektir. Bahsi geçen tümörler ve ilişkili olduğu durumlar şunlardır: seboreik keratoz/ Leser-Trélat belirtisi, lentigo simpleks/ Peutz Jeghers ve Carney sendromu, yağ bezi tümörleri/Muir-Torre sendromu, fibrofoliküloma-trikodiskoma/ Birt-Hogg-Dubé sendromu, trikoepitelyom-silindrom-spiradenom/ BrookeSpiegler sendromu, leiomyom/ multipl kutane ve uterin leiyomiyomatozis sendromu, glomeruloid hemanjiyom/ POEMS sendromu, venöz malformasyon/ Maffucci sendromu, mukozal nörom/ multipl endokrin neoplazi tip 2B, jüvenil ksantogranülom/ jüvenil kronik miyeloid lösemi. Deri tümörleri ve ilişkili olduğu belirtilerin veya sendromların sistemik malinite riskinin bilinmesi, malinitelerin erken tanısı açısından önem taşır. Sum maryThere are various types of benign skin tumors in association with the complex nature of the skin. A minor part of them may be associated with visceral malignancies. This review focuses on the benign skin tumors that are described to have well-known associations with systemic malignancies or those with controversial associations. These tumors and the associated conditions are as follows: seborrheic keratosis/ Leser-Trélat sign, lentigo simplex/Peutz Jeghers and Carney syndrome, sebaceous tumors/ Muir-Torre syndrome, fibrofolliculoma-trichodiskoma/ Birt-Hogg-Dubé syndrome, trichoepitheliomacylindroma-spiradenoma/ Brooke-Spiegler syndrome, leiomyoma/multiple cutaneous and uterin leiomyomatosis syndrome, glomeruloid hemangioma/ POEMS syndrome, venous malformation/ Maffucci syndrome, mucosal neuroma/ multiple endocrine neoplasia type 2B, juvenile xanthogranuloma/ juvenile chronic myeloid leukemia. It is important to know the skin tumors related with visceral malignancies in part of a syndrome or in association with a sign as this may yield an earlier recognition of these malignancies. (Turkderm 2013; 47

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Paraneoplasias

Razera¹,

Okada²,

Bonamigo

2023

Dermatology in Public Health Environments

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Seborrhoeic keratoses in patients with internal malignancies: a case–control study with prospective accrual of patients

Abstract: No association was found between seborrhoeic keratoses and cancer. Furthermore, our data did not provide support to the validity of the Leser-Trélat sign in patients with internal malignancies.

Cited by 19 publications

References 12 publications

Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer

Seborrheic Keratoses as the First Sign of Bladder Carcinoma: Case Report of Leser-Trélat Sign in a Rare Association with Urinary Tract Cancer

Selim deri tümörleri ve sistemik malinite ilişkisi

Paraneoplasias

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