Sebum excretion rate, surface lipid composition and constitutional eczema

Ead, R.D.; Fairbank, R.A.; Cumliffe, W.J.

doi:10.1111/j.1365-2230.1977.tb01576.x

Cited by 9 publications

(2 citation statements)

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“…Furthermore, it has been proved that sebaceous lipids are not reduced in patients with atopic dermatitis compared with those of healthy controls [180,181]. These investigations confirmed previous data of surface lipid levels measured in the forehead area, which have shown no difference between individuals with atopic dermatitis and normal subjects [182]. On the other hand, in consitutionally dry skin, a decreased proportion of neutral lipids (sterol esters, triglycerides) coupled to increased amounts of free fatty acids were found associated with the severity of dry skin [183].…”

Section: Atopic Dermatitissupporting

confidence: 90%

New Pharmaceutical Concepts for Sebaceous Gland Diseases: Implementing Today’s Pre-Clinical Data into Tomorrow’s Daily Clinical Practice

Zampeli¹,

Makrantonaki²,

Tzellos³

et al. 2012

CPB

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The human sebaceous gland is a microscopic branched type multiacinar gland been present everywhere on the body except on the palms and soles, whereas they are sparsely located on the dorsum of hands and feet. Several medical conditions are related with sebaceous gland pathology, such as acne, sebaceous hyperplasia, sebaceous adenoma and sebaceous carcinoma. Acne is a common, complex, chronic disorder of the human pilosebaceous unit that mostly occurs in adolescence and young adulthood. The sebaceous gland plays an exquisite role in the initiation of the disease. The multifactorial nature of the pathogenesis of acne includes increased sebum production, alteration of the quality of sebum lipids, inflammatory processes, interaction with neuropeptides and dysregulation of the hormone microenvironment, follicular hyperkeratinization and inflammation maintained by Propionbacterium acnes products within the follicle. On the other hand, the sebaceous gland, as a major and critical compartment of human skin, is also affected through ageing, both intrinsic and extrinsic, which lead to distinct clinical and histological changes. Intrinsic ageing of the sebaceous gland is determined primarily by genetic factors and hormonal status, with androgens playing a major role. A clinical manifestation associated with intrinsic ageing changes is skin xerosis. Extrinsic ageing of human sebaceous gland is mainly caused by accumulating UV irradiation, especially UVA. Photoageing of sebaceous gland is expressed with a wide spectrum of benign and malignant sebaceous tumours, such as sebaceous hyperplasia, sebaceous carcinoma and Muir-Torre syndrome. This review will focus on the pathogenesis of the most common sebaceous gland diseases and their molecular pathways which may represent future pharmaceutical targets.

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