2022
DOI: 10.1126/sciadv.abo1072
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SEC is an antiangiogenic virulence factor that promotes Staphylococcus aureus endocarditis independent of superantigen activity

Abstract: The superantigen staphylococcal enterotoxin C (SEC) is critical for Staphylococcus aureus infective endocarditis (SAIE) in rabbits. Superantigenicity, its hallmark function, was proposed to be a major underlying mechanism driving SAIE but was not directly tested. With the use of S. aureus MW2 expressing SEC toxoids, we show that superantigenicity does not sufficiently account for vegetation growth, myocardial inflammation, and acute kidney injury in the rabbit mo… Show more

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Cited by 7 publications
(1 citation statement)
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References 71 publications
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“…It uses a collection of cell wall-anchored proteins to promote invasion and adhesion and avoid immunological defenses [34]. S. aureus also produces many toxins, including Staphylococcal enterotoxin C (SEC), which can exert pathogenic effects both as a superantigen and an antiangiogenic factor [35]. When SEC was injected into mouse mammary glands, mammary gland inflammation and severe infective mastitis resulted [36].…”
Section: Breast Milk Microbes Associated With Limmentioning
confidence: 99%
“…It uses a collection of cell wall-anchored proteins to promote invasion and adhesion and avoid immunological defenses [34]. S. aureus also produces many toxins, including Staphylococcal enterotoxin C (SEC), which can exert pathogenic effects both as a superantigen and an antiangiogenic factor [35]. When SEC was injected into mouse mammary glands, mammary gland inflammation and severe infective mastitis resulted [36].…”
Section: Breast Milk Microbes Associated With Limmentioning
confidence: 99%