seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima

Chen, JJ; Hm, Wu; Cf, Peng; Chen, IS; Hung, MC

doi:10.1055/s-0029-1234988

Cited by 4 publications

(5 citation statements)

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“…Additionally, apoptotic cell death is reported for a clerodane diterpene by caspase-3/-7 cleavage and DNA destabilization in L. donovani (Kathuria et al, 2014). Phorbol 12-myristate 13-acetate exhibited an anti-TGF-β antibody activity to restore the lymphoproliferative response of I-SPMC or I-PBMC following stimulation in Leishmania-infected macrophages (Mookerjee et al, 2003), while triptolide (Chen et al, 2009) and ent-kaurene diterpenes (Guimarães et al, 2015) are reported to lead to pathogenic death by changing in calcium homeostasis.…”

Section: Discussionmentioning

confidence: 99%

“…The current review suggests that a number of diterpenes act through reduction of pathogenic infectionmediated oxidative species and pro-inflammatory and/or inflammatory mediators (Alfaro-Bustamante et al, 1997;Chen et al, 2009;Liou et al, 2008;Soares et al, 2012;Miranda et al, 2015), while augmenting the antiinflammatory and interferon levels (D'Agostino et al, 2004;Montero et al, 2004). The diterpene, 5-epiicetexone, is evident to cause cell death by arresting S/G2 phase in T. cruzi (Lozano et al, 2012a), while taxoid 10-deacetylbaccatin III acts on G2/M phase in Leishmania-infected murine macrophages (Georgopoulou et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

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Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diterpenes as lead molecules against neglected tropical diseases

et al. 2016

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“…The full assignment of the 1 H and 13 C-NMR resonances was confirmed by 1 H-1 H COSY, NOESY (l " Table 1), DEPT, HSQC, and HMBC (l " Table 1) techniques. Additionally, compound [14] and (+)-epipinoresinol (7) [15], a coumarin, scopoletin (8) [16], three benzenoids, tetracosyl ferulate (9) [17], syringaldehyde (10) [3], and ficusol (11) [18], two triterpenoids, betulinic acid (12) [19] and squalene (13) [20], a steroid, β-sitosterol (14) [21], and a mixture of fatty alcohols, 1-tetracosanol (15) [22] and 1-hexacosanol (16) [22].…”

Section: Supporting Informationmentioning

confidence: 99%

Orthoquinone and Naphthalenone Derivatives from Berrya ammonilla and Their Anti-Inflammatory Activity

et al. 2012

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A new orthoquinone, berryammone A (1), and four new naphthalenone derivatives, berryammone B (2), berryammone C (3), 6-O-methylberryammone C (4), and 4-O-methylberryammone C (5), have been isolated from the stem of Berrya ammonilla, together with eleven known compounds (6-16). The structures of these new compounds were determined through spectroscopic and MS analyses. Among the isolates, compounds 1-3, 5, (+)-pinoresinol (6), and betulinic acid (12) exhibited inhibition (IC50 ≤ 4.41 µM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 2, and 5 also inhibited fMLP/CB-induced elastase release with IC50 values ≤ 3.95 µM.

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“…Erythrophloin C (10) and suberosol B (11), two constituents from the roots of Beilschmiedia erythrophloia, exhibited anti-TB activity against Mtb H 37 Rv, showing MIC values of 50 and 28.9 μg/mL, respectively [42]. Two new seco-abietane diterpenoids isolated from the leaves and twigs of Callicarpa pilosissima, 12-deoxy-11,12-dihydro-secohinokiol methyl ester (12) and callicarpic acid B (13) exhibit anti-TB activities against Mtb H 37 Rv in vitro with MICs of 38.0 and 63.6 μM, respectively [43].…”

Section: Newly Reported Anti-tb Natural Products From 2009 To Presentmentioning

confidence: 99%

Stereochemistry at the Forefront in the Design and Discovery of Novel Anti-tuberculosis Agents

Huang

Kozikowski³

2011

CTMC

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Today, 75% of new drugs introduced to the market are single enantiomers and new techniques in asymmetric synthesis and chiral separation expedites chiral drug discovery and development worldwide. The enantiomers of a chiral drug present unique chemical and pharmacological behaviors in a chiral environment, such as the human body, in which the stereochemistry of chiral drugs determines their pharmacokinetic, pharmacodynamic, and toxicological actions. Thus, it is imperative that only the pure and therapeutically active isomer be prepared and marketed. Tuberculosis (TB), a highly contagious and airborne disease that is caused by infection with Mycobacterium tuberculosis (Mtb), currently represents one of the most threatening health problems globally. The emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB), as well as HIV co-infection along with a lengthy treatment regimen, highlights an urgent need for the development of new anti-TB agents. Currently, new chiral anti-TB agents are being developed from some well-known anti-TB agents, high throughput screening (HTS) hits, and natural products. This review will focus on the reported chiral anti-TB agents together with the clinical importance of their chirality and stereochemistry.

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seco-Abietane diterpenoids, a phenylethanoid derivative, and antitubercular constituents from Callicarpa pilosissima

Cited by 4 publications

References 0 publications

Diterpenes as lead molecules against neglected tropical diseases

Diterpenes as lead molecules against neglected tropical diseases

Orthoquinone and Naphthalenone Derivatives from Berrya ammonilla and Their Anti-Inflammatory Activity

Stereochemistry at the Forefront in the Design and Discovery of Novel Anti-tuberculosis Agents

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