Second cancer after radiation therapy for cancer of the uterine cervix

Abstract

Radiation-induced cancers after radiation therapy for cancer of the uterine cervix were investigated on 11,855 patients including 5725 patients treated with radiation therapy alone, 1969 postoperative radiation therapy and 4161 surgery alone. The observed-to-expected ratios of the second primary cancer was 0.933 for the patients with radiation therapy alone and 1.074 for the patients with postoperative radiation therapy, respectively. No significant increase was observed in the risk of second primary cancers when all sites were combined. However, assessing on site by site basis, significant excess was noted for the rectum cancer, leukemia, and bladder cancer for the radiation therapy group but not for the surgery group. A significant excess of lung cancer was observed in both radiation therapy and surgery groups, which was attributed to some other causative factors. Radiation-induced cancers were suggested to develop apparently in organs involved in the irradiated field. Cancer 67:398-405,1991.

Risk of second primary malignancies in women with cervical cancer: A population-based study in Taiwan over a 30-year period

“…Arai et al analyzed 11,855 patients with cervical cancer in four institutions from 1961 to 1981 and did not find an elevated risk for either the radiation or surgery group when all sites were combined. However, when evaluated on a site-by-site base, significant elevation of risk was found for rectal, lung, bladder, and leukemia cancer in the radiation group, and lung cancer only for the surgery group [17]. In the present study, we analyzed the incidence and risk of second primary cancers using a population-based cohort of 52,972 patients with an initial diagnosis of cervical cancer between 1979 and 2008 in Taiwan.…”

Treatment of squamous cell carcinoma of the uterine cervix with radiation therapy alone: long-term survival, late complications, and incidence of second cancers

“…They found an increased risk for cancers of the bladder, rectum, vagina, and caecum. Arai et al (1991) reported significantly higher incidences of second cancers in the rectum, bladder, and lung as well as leukaemia. Kleinerman et al (1995) described a large-scale study of 49 828 patients with cervical cancer treated with radiation therapy and 16 713 matched patients treated without radiotherapy.…”

Increased Risk of Second Primary Malignancies in Patients with Gynecological Cancer: A Swedish record-linkage study

“…This follows the pattern for radiation-induced SPM but has not been shown by other groups ( I , 4, 20,23,24). It is of interest to compare this finding with results from the evaluation of the Radiumhemmet series of carcinoma of the cervix treated in 1914-1965 (21).…”