Second generation antipsychotics &amp; nocturnal enuresis in children

Thiel, J. H.

doi:10.9740/mhc.n146896

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Urinary incontinence is a less understood complication of second-generation antipsychotic drugs, and the incidence of this adverse effect has not been well established. Urinary incontinence and/or nocturnal enuresis may occur in only 0.2% of patients, but ranges up to 42% have been found in the literature [8][9][10][11], making the actual incidence of antipsychoticinduced urinary incontinence unclear. Currently, in the United States, the research on urinary incontinence as a side effect of atypical antipsychotic use for schizophrenic spectrum disorders is limited to a small number of case studies.…”

Section: Introductionmentioning

confidence: 99%

A Case of Risperidone-Induced Urinary Incontinence

Eierman,

Reischman,

Gouthro

2024

Cureus

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Schizophrenia spectrum disorders are psychiatric conditions associated with an increased risk of all-cause mortality; patients with these conditions have a shortened average lifespan compared to the general population. First-line treatment for schizophrenia spectrum illness consists of atypical antipsychotics, which are associated with well-understood side effects, including metabolic syndrome, anticholinergic effects, and extrapyramidal symptoms. We are presenting a case of a 36-year-old patient treated with the atypical antipsychotic risperidone who experienced treatment-associated urinary incontinence. In the current literature, atypical antipsychotic-induced urinary incontinence is not well-documented in patients with schizophrenia spectrum disorder. Incontinence is often a topic of societal shame for many patients, and as a side effect, it may influence medication compliance. In the treatment of schizophrenia spectrum disorders, compliance is essential to prevent psychosis relapse in patients, so prescribers must be aware of this potential side effect and how to manage it. Upon a patient presenting with incontinence suspected to be due to atypical antipsychotics, other more common causes of incontinence must first be ruled out. Then, further management can consist of stopping the offending medication or adding a medication to address the incontinence. In this case, our patient had an extended history of suboptimal treated schizoaffective disorder, and risperidone was providing significant improvement; therefore, to ensure continued improvement, we initiated oxybutynin to manage urinary incontinence.

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Section: Introductionmentioning

confidence: 99%

A Case of Risperidone-Induced Urinary Incontinence

Eierman,

Reischman,

Gouthro

2024

Cureus

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“…It is plausible that individuals who experience risperidoneinduced enuresis will have similar effects with other antipsychotics therefore increasing the overall risk of noncompliance with their medications and increasing the likelihood of symptom relapse with a decline in quality of life. Several pharmacologic interventions for risperidone-induced enuresis such as anticholinergics, alpha-1 agonists, and desmopressin have been tried and varied in their success [4]. For risperidone-induced enuresis specifically, reboxetine, a selective noradrenaline reuptake inhibitor antidepressant, has been successful in resolving symptoms of enuresis, suggesting a central noradrenergic cause of risperidone-induced enuresis [5].…”

Section: Introductionmentioning

confidence: 99%

Risperidone-associated enuresis—a case report

Sarangi

Mkhantar

Weaver

2021

Middle East Curr Psychiatry

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Background Risperidone has been reported to be effective in treating both the positive and negative symptoms of schizophrenia, aggression, and behavioral disorders. While the metabolic side effect profile of this medication has been broadly studied, studies related to this medication’s bladder effects are relatively rare. We present a case of risperidone-induced enuresis in an adult male with schizophrenia that resolved upon discontinuation of the offending medication. Case presentation We describe a case of a 32-year-old man with a primary psychotic disorder who developed debilitating enuresis secondary to taking risperidone. Enuresis resolved upon switching to Seroquel. Conclusion Enuresis secondary to risperidone is not commonly discussed prior to initiation by the treating psychiatrist however can be debilitating. Discussing this potential side effect is critical to informed decision making on the patient’s part.

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Second generation antipsychotics & nocturnal enuresis in children

Abstract: Nocturnal enuresis, or involuntary wetting during sleep, is an adverse drug reaction that may occur with numerous second generation antipsychotics (SGAs) and currently is underreported. This article reviews SGA-induced enuresis and its management.

Cited by 2 publications

References 13 publications

A Case of Risperidone-Induced Urinary Incontinence

A Case of Risperidone-Induced Urinary Incontinence

Risperidone-associated enuresis—a case report

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