Second-Generation Chiral Amino Acid Derivatives Afford High Stereoselectivity and Stability in Aqueous RNA Acylation
Ryuta Shioi,
Sayantan Chatterjee,
Lu Xiao
et al.
Abstract:Activated
acyl species have proven versatile in the esterification
of 2′–OH groups in RNA, enabling structure mapping,
caging, profiling, and labeling of the biopolymer. Nearly all reagents
developed for this reaction have been achiral; however, a recent study
reported that simple chiral amino acid acylimidazole derivatives could
yield diastereoselective reactions at RNA 2′–OH in water,
enabling up to 4:1 selectivity in screening. Here, we investigated
the effect of steric bulk on the stereoselectivity of RNA … Show more
Electrophilic water-soluble compounds have proven versatile in reacting selectively with 2'-OH groups in RNA, enabling structure mapping, probing, caging, labeling, crosslinking, and conjugation of RNAs in vitro and in living...
Electrophilic water-soluble compounds have proven versatile in reacting selectively with 2'-OH groups in RNA, enabling structure mapping, probing, caging, labeling, crosslinking, and conjugation of RNAs in vitro and in living...
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