Second generation of meniscus transplantation: in-vivo study with tissue engineered meniscus replacement

Martinek, V.; Ueblacker, Peter; Braun, Kátia Olmedo; Nitschke, Stephan; Mannhardt, R.; Specht, Katja; Gänsbacher, Bernd; Imhoff, Andreas B.

doi:10.1007/s00402-005-0025-1

Cited by 110 publications

(94 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In sheep models, the meniscus transplant horns are generally fixed with transosseous sutures. 9,15,20,21,23 Considering that most of the animal studies reports high incidence of implant lesions at longer follow-up, 9,15,23 we have decided to compare two different implant fixation techniques to determine a most suitable animal model for total meniscal substitution. The degree of damage seen in the meniscal implants at the completion of our study appears related to the implant fixation technique used.…”

Section: Discussionmentioning

confidence: 99%

“…Despite improvements in pain and selfevaluation, 12 the histological and magnetic resonance imaging (MRI) results remain controversial. 10,13,15 Several materials have been tested as partial meniscus substitutes in animal models. Veth et al 16 used carbon fiber for meniscus repair in dogs, with unsatisfactory results.…”

Section: Introduction Lmentioning

confidence: 99%

“…[21][22][23] Tissue engineering has recently been proposed as a possible solution for meniscal regeneration. 15,[24][25][26][27][28] There have, however, been very few animal studies reported in the literature that have investigated the possibility of using cells in a partial or total meniscal substitute. 15, 24 Walsh et al 25 used a collagenous sponge loaded with mesenchymal stem cells to heal a partial meniscus defect in rabbits and reported that the presence of cells augmented the repair process but did not prevent degenerative osteoarthritis.…”

Section: Introduction Lmentioning

confidence: 99%

“…Martinek et al 15 reported better macroscopic and histological results in CMI implants seeded with meniscal fibrochondrocytes in comparison to cell-free implants in sheep. However, the tissue-engineered meniscus was biomechanically unstable and the implant size reduced during the 3-month observation period.…”

Section: Introduction Lmentioning

confidence: 99%

See 3 more Smart Citations

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Kon

Chiari

Marcacci

et al. 2008

Tissue Engineering Part A

113

View full text Add to dashboard Cite

Objective: The aim of the study was to investigate the use of a novel hyaluronic acid/polycaprolactone material for meniscal tissue engineering and to evaluate the tissue regeneration after the augmentation of the implant with expanded autologous chondrocytes. Two different surgical implantation techniques in a sheep model were evaluated. Methods: Twenty-four skeletally mature sheep were treated with total medial meniscus replacements, while two meniscectomies served as empty controls. The animals were divided into two groups: cell-free scaffold and scaffold seeded with autologous chondrocytes. Two different surgical techniques were compared: in 12 animals, the implant was sutured to the capsule and to the meniscal ligament; in the other 12 animals, also a transtibial fixation of the horns was used. The animals were euthanized after 4 months. The specimens were assessed by gross inspection and histology.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introduction Lmentioning

confidence: 99%

Section: Introduction Lmentioning

confidence: 99%

Section: Introduction Lmentioning

confidence: 99%

See 2 more Smart Citations

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Kon

Chiari

Marcacci

et al. 2008

Tissue Engineering Part A

113

View full text Add to dashboard Cite

show abstract

“…Since an outer rim of meniscal tissue is needed for CMI implantation, it is indicated only for partial and not total meniscus regeneration. Satisfactory clinical results have been reported (Rodkey et al, 1999), while MRI and histological results are controversial: (i) the CMI shrinks over time; (ii) it showed no histological remnants 5 to 6 years after implantation (Steadman and Rodkey, 2005); and (iii) it predominantly generates a scar tissue instead of fibrocartilage (Martinek et al, 2006). In a recent mediumterm follow-up, non-controlled case series involving 34 patients, Bulgheroni et al (2010) showed good to excellent clinical results after 5 years from a CMI implantation for a symptomatic deficiency of medial meniscal tissue.…”

Section: Cell-free Techniquesmentioning

confidence: 99%

Meniscus repair and regeneration: review on current methods and research potential

Scotti

Hirschmann

Antinolfi

et al. 2013

eCM

130

123

View full text Add to dashboard Cite

Meniscus regeneration is an unsolved clinical challenge. Despite the wide acceptance of the degenerative consequences of meniscectomy, no surgical procedure has succeeded to date in regenerating a functional and long-lasting meniscal fibrocartilage. Research proposed a number of experimental approaches encompassing all the typical strategies of regenerative medicine: cellfree scaffolds, gene therapy, intra-articular delivery of progenitor cells, biological glues for enhanced bonding of reparable tears, partial and total tissue engineered meniscus replacement. None of these approaches has been completely successful and can be considered suitable for all patients, as meniscal tears require specific and patientrelated treatments depending on the size and type of lesion. Recent advances in cell biology, biomaterial science and bioengineering (e.g., bioreactors) have now the potential to drive meniscus regeneration into a series of clinically relevant strategies. In this tutorial paper, the clinical need for meniscus regeneration strategies will be explained, and past and current experimental studies on meniscus regeneration will be reported.

show abstract

S oft T issue R epair and R egeneration: Composite Materials Toward the Design of Advanced Prostheses and Scaffolds

Gloria

Russo

D’Amora

et al. 2012

Wiley Encyclopedia of Composites

View full text Add to dashboard Cite

The restoration of tissue biomechanical function represents a great challenge, underlining the need to mimic tissue structure and mechanical behavior through suitable prosthesis and scaffold designs. For this reason, several materials, technologies, and designs have been widely proposed and studied from an experimental and/or a clinical point of view. Polymer‐based composite materials are suitable candidates for applications where high strength‐to‐weight and stiffness‐to‐weight ratios and specific performances are required. Taking into account tissue structure‐function relationships, the design of biomimetic composite devices able to reproduce the multiscale structural hierarchy of complex tissues represents a crucial feature for tissue repair and regeneration. In particular, this article aims at stressing the importance of polymer‐based composite materials to design advanced prostheses and scaffolds for soft tissue engineering, with a special focus on tendons, ligaments, intervertebral disk, and meniscus.

show abstract

Second generation of meniscus transplantation: in-vivo study with tissue engineered meniscus replacement

Cited by 110 publications

References 38 publications

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Tissue Engineering for Total Meniscal Substitution: Animal Study in Sheep Model

Meniscus repair and regeneration: review on current methods and research potential

S oft T issue R epair and R egeneration: Composite Materials Toward the Design of Advanced Prostheses and Scaffolds

Contact Info

Product

Resources

About