2009
DOI: 10.1097/coc.0b013e31818c08ff
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Second-Line Treatment With a Combination of Continuous 5-Fluorouracil, Doxorubicin, and Mitomycin-C (Conti-Fam) in Gemcitabine-Pretreated Pancreatic and Biliary Tract Cancer

Abstract: The conti-FAM regimen seems to constitute a safe and feasible salvage therapy in patients with advanced bilio-pancreatic cancer who had been treated previously via gemcitabine-based chemotherapy.

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Cited by 55 publications
(42 citation statements)
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“…FU therapy, gemcitabine based therapy, sunitinib, and imatinib are among those studied in the second-line setting (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Median time to progression (TTP) seen with these regimens ranged from 1.6 to 5.5 months.…”
Section: Discussionmentioning
confidence: 99%
“…FU therapy, gemcitabine based therapy, sunitinib, and imatinib are among those studied in the second-line setting (11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Median time to progression (TTP) seen with these regimens ranged from 1.6 to 5.5 months.…”
Section: Discussionmentioning
confidence: 99%
“…Standard second-line chemotherapies have not been proposed, although a number of new regimens are now investigated [35,36,37]. Recently, S-1, oral fluoropyrimidine derivatives, showed mild toxicity and modest efficacy for the treatment of BTC [38,39,40].…”
Section: Discussionmentioning
confidence: 99%
“…Because there is no established survival data for patients who have failed palliative chemotherapy for advanced BTC, survival data from a published phase II study in a similar clinical setting was used. Based on prior phase II trials, patients who failed prior chemotherapy had a 6-month survival rate of 15–30% and a median survival of 4–6 months [16,17,18,19]. Forty-four patients would be sufficient to discriminate between a 6-month survival rate of 20% (H0) and 32% (H1) with 75% power (one-sided alpha error: 0.05).…”
Section: Methodsmentioning
confidence: 99%
“…A salvage regimen to treat patients with previous GEM-based or 5-FU-based chemotherapy is imperative with an increasing proportion of patients who are in need of further systemic treatment, while maintaining a sufficient performance status (PS). There are only a few published studies which have investigated salvage chemotherapy in patients with advanced BTC after failure of GEM-based or 5-FU-based regimens [16,17,18,19]. …”
Section: Introductionmentioning
confidence: 99%
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