Second-Look Arthroscopic Evaluation of Cartilage Lesions After Mesenchymal Stem Cell Implantation in Osteoarthritic Knees

Koh, Yong‐Gon; Choi, Young-Wook; Kwon, Oh Ryong; Kim, Yong Sang

doi:10.1177/0363546514529641

Cited by 143 publications

(141 citation statements)

References 59 publications

Supporting

Mentioning

133

Contrasting

Order By: Relevance

“…Four systematic reviews (35)(36)(37)(38) were also excluded. An assessment of the remaining 18 studies revealed that 10 used a single-arm prospective design (18)(19)(20)(39)(40)(41)(42)(43)(44)(45), four used quasi-experimental trials (46)(47)(48)(49) and four used RCT (50-53) (Table I). A total of 565 participants (226 males and 339 females) were included from the 18 studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Cui

Wang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells. The effect sizes of selected studies were determined by extracting pain scores from the visual analog scale and functional changes from International Knee Documentation Committee and Lysholm and Western Ontario and McMaster Universities Osteoarthritis Index before and after MSCs or reference treatments at 3, 6, 12, and 24 months. The factors were analyzed and the outcomes were modified after comparing the MSC group pooled values with the pretreatment baseline or between different treatment arms. A systematic search identified 18 clinical trials on this topic, including 10 single-arm prospective studies, four quasi-experimental studies and four randomized controlled trials that used BMCs to treat 565 patients with KOA in total. MSC treatment in patients with KOA showed continual efficacy for 24 months compared with their pretreatment condition. Effectiveness of MSCs was improved at 12 and 24 months post-treatment, compared with at 3 and 6 months. No dose-responsive association in the MSCs numbers was demonstrated. However, patients with arthroscopic debridement, activation agent or lower degrees of Kellgren-Lawrence grade achieved improved outcomes. MSC application ameliorated the overall outcomes of patients with KOA, including pain relief and functional improvement from basal evaluations, particularly at 12 and 24 months after follow-up.

show abstract

Section: Study Characteristicsmentioning

confidence: 99%

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Cui

Wang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…4 There have been multiple studies investigating the efficacy of stem cells in the treatment of both isolated cartilage lesions and osteoarthritis. 5 Pertinent to sports medicine, Koh et al 6 compared patients receiving microfracture surgery for cartilage defects of the knee with and without augmentation with adipose-derived stem cells. In a relatively small series, they demonstrated improved radiologic and subjective pain scores in the group receiving stem cell augmentation, although there was no difference in activity or quality of life.…”

Section: Clinical Applicationmentioning

confidence: 99%

Adipose-derived Mesenchymal Stem Cells and Arthroscopic Surgery

Moorman¹,

Godin²,

Pecchia³

et al. 2017

The Duke Orthopaedic Journal

View full text Add to dashboard Cite

show abstract

“…Recent non-controlled clinical studies showed that local injections of ASCs improved clinical symptoms of pain and WOMAC index (i.e. a functional score), and reported that up to 100 millions of cells were well tolerated [54,55].…”

Section: Human Regenerative Therapy In Oamentioning

confidence: 99%

Adipose derived stem cells for regenerative therapy in osteoarticular diseases

Pers

Jørgensen

2016

Hormone Molecular Biology and Clinical Investigation

View full text Add to dashboard Cite

Abstract:In the recent years, adipose derived stem cells (ASCs) led to significant findings in the field of regenerative therapy. ASCs have various biological properties and capacity as differentiation in three lineages (chondrocytes, osteocytes and adipocytes) or immunomodulation by releasing paracrine factors. Osteoarthritis (OA) is the most frequent osteoarticular disease characterized by none curative treatment. We reviewed all current data on the proof of concept of ASCs in OA pathophysiology as well as an inventory of ASC promising cell therapy in OA.

show abstract

Second-Look Arthroscopic Evaluation of Cartilage Lesions After Mesenchymal Stem Cell Implantation in Osteoarthritic Knees

Cited by 143 publications

References 59 publications

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: A meta-analysis

Adipose-derived Mesenchymal Stem Cells and Arthroscopic Surgery

Adipose derived stem cells for regenerative therapy in osteoarticular diseases

Contact Info

Product

Resources

About