Second-Look Colonoscopies and the Impact on Capacity in FIT-Based Colorectal Cancer Screening

Grobbee, Esmée J.; Kapidzic, Atija; Leerdam, Monique E. van; Lansdorp–Vogelaar, Iris; Looman, Caspar W.N.; Bruno, Marco J.; Kuipers, Ernst J.; Spaander, Manon

doi:10.1038/ajg.2015.157

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…Combining individual fecal Hb concentrations with other risk factors for CRC to base colonoscopy indication on, and not solely a qualitative test result, could possibly improve FIT-screening efficiency. Also, FIT could be of clinical importance after the initial positive test result, because the fecal Hb concentration is associated with the risk of a second colonoscopy within 1 year after screening colonoscopy [ 41 ]. Future research in FIT screening should therefore explore the possibilities of incorporating individual fecal Hb levels in CRC screening programs.…”

Section: Fecal Occult Blood Testsmentioning

confidence: 99%

Advances in Fecal Tests for Colorectal Cancer Screening

Schreuders

Grobbee

Spaander

et al. 2016

Curr Treat Options Gastro

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Opinion statementColorectal cancer (CRC) forms an important public health problem, especially in developed countries. CRC screening tests can be used to identify asymptomatic individuals with CRC precursors and (early) cancer. Removal of these lesions reduces CRC incidence and prevents CRC-related mortality. There are a range of screening tests available, each with advantages and disadvantages. Stool screening tests can broadly be divided into fecal occult blood tests (FOBTs) and molecular biomarker test, such as DNA/RNA marker tests, protein markers, and fecal microbiome marker tests. Guaiac fecal occult blood tests (gFOBT) have been demonstrated in large randomized screening trials to reduce CRC mortality. Fecal immunochemical tests (FIT) have superior adherence, usability, and accuracy as compared to gFOBT. Advantage of the use of quantitative FITs in CRC screening programs is the cut-off level that can be adjusted. Molecular biomarker DNA tests have shown to detect significantly more cancers than FIT. By combining biomarker DNA tests with FIT, sensitivity for advanced adenomas can be increased significantly. However, it has lower specificity thus demands more colonoscopy resources, is more cumbersome, and costly. The adherence has not been assessed in population screening trials. For these reasons, FIT is therefore at present regarded as the preferred method of non-invasive CRC screening. This chapter will review the current status of fecal test-based CRC screening.

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Section: Fecal Occult Blood Testsmentioning

confidence: 99%

Advances in Fecal Tests for Colorectal Cancer Screening

Schreuders

Grobbee

Spaander

et al. 2016

Curr Treat Options Gastro

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“…Second-look colonoscopies (within 1 year) could be indicated in some cases (inappropriate preparation, additional polypectomy or follow-up of resection completeness). A value of 12.3%[ 20 ] was included in the model.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Prediction of the Demand of Colonoscopies Generated by a Population-Based Colorectal Cancer Screening Program

et al. 2016

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ObjectiveTo estimate the long-term need for colonoscopies after a positive fecal immunochemical test (FIT) and post-polypectomy surveillance in the context of a population-based colorectal cancer (CRC) screening program.MethodsA discrete-event simulation model was built to reproduce the process of CRC screening and post-polypectomy surveillance following European guidelines in a population of 100,000 men and women aged 50–69 years over a 20-year period. Screening consisted of biennial FIT and colonoscopy in participants with positive results. The model was mainly fed using data from the first and second rounds of a Spanish program (2010–2013). Data on post-polypectomy surveillance results were obtained from the literature. A probabilistic multivariate sensitivity analysis was performed on the effect of participation, FIT positivity, and adherence to surveillance colonoscopies. The main outcome variables were the number of colonoscopies after a positive FIT, surveillance colonoscopies, and the overall number of colonoscopies.ResultsAn average yearly number of 1,200 colonoscopies after a positive FIT were predicted per 100,000 inhabitants with a slight increase to 1,400 at the end of the 20-year period. Surveillance colonoscopies increased to an average of 1,000 per 100,000 inhabitants in the long-term, showing certain stabilization in the last years of the 20-year simulation horizon. The results were highly sensitive to FIT positivity.ConclusionsImplementing a population-based CRC screening program will increase the demand for colonoscopies, which is expected to double in 20 years, mainly due to an increase in surveillance colonoscopies.

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Follow-Up of Patients with Surgical Colorectal Cancer Resection

Uğurlu

2020

Colon Polyps and Colorectal Cancer

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Second-Look Colonoscopies and the Impact on Capacity in FIT-Based Colorectal Cancer Screening

Cited by 7 publications

References 34 publications

Advances in Fecal Tests for Colorectal Cancer Screening

Advances in Fecal Tests for Colorectal Cancer Screening

Long-Term Prediction of the Demand of Colonoscopies Generated by a Population-Based Colorectal Cancer Screening Program

Follow-Up of Patients with Surgical Colorectal Cancer Resection

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