Second lower genital tract squamous cell carcinoma following cervical cancer: A clinical study of 46 patients

Senkus, Elżbieta; Konefka, T; Nowaczyk, Monika; Jassem, Jacek

doi:10.3109/00016340009169191

Cited by 6 publications

(8 citation statements)

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“…No prognostic factors for survival were identified. 2 Misdiagnosis of second malignancies may occur, as happened in the case of postirradiation bladder cancer reported by Nimmanon and Ruengpoka, in which malignant fibrous hystiocytoma of the urinary bladder that occurred 15 years after radiation therapy for cervical cancer, was misdiagnosed initially as high grade urothelial carcinoma. 11 Endometrial cancers are usually diagnosed by performing endometrial biopsy or fractional curettage for postmenopausal bleeding.…”

Section: Discussionmentioning

confidence: 93%

“…1 A retrospective analysis of 46 second cancers of the lower genital tract reported the mean age of patients at the time of diagnosis of the second cancer to be 63 years, and the median time for their diagnosis or discovery to be 206 months. 2 Estimating the risk of all second cancers among 104,760 one year survivors of cervical cancer, it was found that the overall risk was increased significantly. And it was increased further when compared with those who did not receive radiation.…”

Section: Discussionmentioning

confidence: 99%

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Second Malignancy Following Radiotherapy for Carcinoma of the Cervix: Clear Cell Adenocarcinoma of the Endometrium Infiltrating the Uterus and Ovary

Dasari

2012

Journal of Gynecologic Surgery

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Background: Second malignancy is one of the late complications for long-term cancer survivors, treated with radiation or chemotherapy. Various types of second malignancies after radiation therapy for carcinoma of the cervix were reported in the literature. Here, a case of clear cell adenocarcinoma of the uterus, which was misdiagnosed clinically as ovarian tumor, is reported. Case: A 74-year-old multiparous, postmenopausal woman with a past history of radiation treatment for carcinoma of the cervix was admitted as a case of ovarian tumor. At laparotomy, it was recognized as a pyometra with a mass in the cavity of uterus, and the cervix was not seen per vaginum. Results: Subtotal hysterectomy with bilateral salphingo oopherectomy was performed. The histopathology revealed clear cell adenocarcinoma of the endometrium infiltrating the uterus up to the serosa and completely replacing the right ovarian stroma. Conclusions: A second malignancy should be suspected in elderly women who present with a mass in the abdomen or pelvis, and investigations should be directed to rule out the same so that proper management can be planned prior to surgery. ( J GYNECOL SURG 28:379)

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Second Malignancy Following Radiotherapy for Carcinoma of the Cervix: Clear Cell Adenocarcinoma of the Endometrium Infiltrating the Uterus and Ovary

Dasari

2012

Journal of Gynecologic Surgery

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“…Modalities of treatment for vaginal radiation-induced carcinoma were quite different based on radical surgery or exenteration, radiotherapy, or palliative chemotherapy. 13,15,21 Senkus et al 21 reported that the intent of treatment for a secondary tumor and the stage of the secondary tumor did not represent significant prognostic factors. 21 In fact, it is difficult to assess precisely the …”

Section: Discussionmentioning

confidence: 98%

“…In a retrospective study conducted by Senkus et al 21 concerning 35 radiation-induced squamous cell carcinoma of the vagina or the vulva, 24 tumors were located within the high dose volume and 11 within the scattered irradiation area. The time span between pelvic irradiation and vaginal/ vulvar cancers ranged from 79 to 402 months (median 219 months).…”

Section: Discussionmentioning

confidence: 99%

“…Senkus et al reported a median survival of 52 months in their study, which includes 35 vaginal and vulvar carcinoma following pelvic radiotherapy among 46 patients. 21 The poor prognosis may be explained by the significant delay in diagnosis, the advanced stage of illness, the aggressive histology subtypes and high grade of such radiation-induced tumors, 18,21,22 and the modalities of treatment; in fact there is a high number of patients that receive only palliative treatment due to difficulties in performing another aggressive therapy following previous radical surgery and/or radiotherapy. Due to the fear of complication, the intent of treatment for a secondary pelvic tumor is, in most cases, palliative.…”

Section: Radio-induced Carcinomamentioning

confidence: 99%

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Squamous Cell Carcinoma of the Vaginal Vault Following Whole Pelvic Radiation Therapy and Surgery

Lagha¹,

Ayadi²,

Krimi³

et al. 2013

Journal of Gynecologic Surgery

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Background: Here, we report the case of a patient with endometrial carcinoma stage IB who was diagnosed with squamous cell carcinoma of the vaginal vault 10 years after radiotherapy. Case: A 55-year-old female patient with endometrial carcinoma FIGO stage IB received pelvic irradiation and underwent surgery for her disease. After 10 years, she experienced vaginal bleeding and was subsequently diagnosed with squamous cell carcinoma of the vaginal vault. No distant metastases were identified and the patient was not a candidate for surgery. She received chemotherapy using a combination of 5-fluoruracil and cisplatin, but it was ineffective. The patient is still alive with a progressive disease. Conclusion: Long-term follow-up and aggressive investigation, which even include tissue biopsy, are mandatory whenever patients with a past medical history of pelvic irradiation experience any pelvic symptoms in order to detect early occult second malignancies. ( J GYNECOL SURG 29:56)

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Simultaneous diagnosis and therapy of invasive cervical carcinoma and invasive vulvar carcinoma. A case report

Glišić

2005

Arch Gynecol Obstet

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Invasive squamous cell carcinoma of the vulva is predominantly a disease of postmenopausal woman with a mean age of approximately 65 years. After treatment for cervical cancer patients have an increased risk of developing second squamous cell malignancy of the lower genital tract. This study reports the case of a patient with double malignancy-invasive cervical cancer and invasive vulvar cancer. She underwent radical hysterectomy, bilateral adnexectomy and pelvic bilateral lymphadenectomy and at the same time radical vulvectomy and bilateral inguinal lymphadenectomy. After surgery she was referred to radiotherapy. The postoperative course was uneventful and at 14 months of follow-up, the patient showed no evidence of recurrence.

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Second lower genital tract squamous cell carcinoma following cervical cancer: A clinical study of 46 patients

Abstract: Treatment outcome in patients with second lower genital tract carcinoma is unsatisfactory due to poor feasibility of another definite treatment after previous radical surgery and/or radiotherapy.

Cited by 6 publications

References 0 publications

Second Malignancy Following Radiotherapy for Carcinoma of the Cervix: Clear Cell Adenocarcinoma of the Endometrium Infiltrating the Uterus and Ovary

Second Malignancy Following Radiotherapy for Carcinoma of the Cervix: Clear Cell Adenocarcinoma of the Endometrium Infiltrating the Uterus and Ovary

Squamous Cell Carcinoma of the Vaginal Vault Following Whole Pelvic Radiation Therapy and Surgery

Simultaneous diagnosis and therapy of invasive cervical carcinoma and invasive vulvar carcinoma. A case report

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