Second malignancies in patients who have head and neck cancer: Incidence, effect on survival and implications based on the RTOG experience

Cooper, Jay S.; Pajak, Thomas F.; Rubin, Philip; Tupchong, Leslie; Brady, Luther W.; Leibel, Steven A.; Laramore, George E.; Marcial, Víctor A.; Davis, Lawrence W.; Cox, James D.

doi:10.1016/0360-3016(89)90094-1

Cited by 361 publications

(177 citation statements)

References 17 publications

Supporting

Mentioning

164

Contrasting

Unclassified

Order By: Relevance

“…Seventeen had a SPT in the lung, while in three cases the lesion was identified by ICC and subsequently clinically and/or pathologically as metastatic from a colon, a breast and a prostate carcinoma. These findings bear particular relevance in melanoma patients who have an increased risk of developing a pulmonary SPT (Perry et al, 1986), and in patients with head and neck cancer, which most frequently metastatize to the lung (Cooper et al, 1989;McDonald et al, 1989). In addition, metastatic melanoma may often be amelanotic, as also evident in our group of patients, thus raising further diagnostic problems.…”

Section: Discussionsupporting

confidence: 59%

See 1 more Smart Citation

Identification of second malignancies on effusions and fine-needle aspirates using a panel of monoclonal antibodies

Mottolese¹,

Venturo

Rinaldi

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

Summary The longer survival of neoplastic patients achieved through improvements of therapeutic regimens has increased the relative risk of developing a second primary tumour (SPT). In this context, conventional cytopathology can define tumour histotype only in a small fraction of cases. In this study, we have evaluated whether selected combinations of monoclonal antibodies (MAbs) to tumour-associated antigens (TAAs) al, 1986;Tucker et al, 1988) and solid tumours (Lee, 1986;Kaldor et al, 1987). As early diagnosis of SPTs has major therapeutic and epidemiological relevance (Kaldor et al, 1987;Giardini et al, 1993), the development of new methods for the accurate detection of second malignancies should be attempted. In this context, exfoliative and FNA cytology may be considered a valuable and accurate diagnostic technique, easy to perform on a large scale during the follow-up of patients previously treated for malignant tumours. These methods also have the advantage of minimal morbidity and low cost (Koss, 1988). While this approach has been reported to be highly accurate in identifying metastatic cells, the possibility of defining the tumour histotype has been far less successful (Friedman et al, 1983;Hajdu et al, 1984). We have previously reported that the use of selected combinations of MAbs to TAAs can be applied to a number of areas of cytodiagnosis of solid tumours, thus increasing the accuracy of conventional morphology in identifying metastases from unknown primary tumour and in differentiating primary from metastatic lesions (Mottolese et al, 1993). In the present study, we have analysed, in a large group of patients with a past history of malignancy, whether the use of a similar panel of reagents may also be useful in detecting SPTs in two areas of cytopathology, which are particularly difficult on the basis of morphological criteria, namely that of effusions and of pulmonary FNA. MATERIALS AND METHODS PatientsFrom January 1990 to June 1995, 334 cytological specimens, of which 91 were pulmonary FNA and 243 pleural and peritoneal effusions sampled from patients previously treated with chemo and/or radiotherapy for different malignant tumours, were analysed both cytologically and immunocytochemically (ICC). The series consisted of 93 patients with effusions and 52 with solitary or multiple pulmonary masses, which appeared within 5 years of a previous tumour, while 189 patients developed effusions (150 cases) or radiologically assessed lung lesions (39 cases) at least 5 years after the first tumour. Only those cases in which morphological examination assessed the presence of malignant cells on cytological specimens have been included in this study. Unsatisfactory or insufficient specimens were excluded. Preparation of cell substratesPleural and peritoneal effusions were collected in sterile conditions using heparin (Liquemin Roche) as anticoagulant. Samples were centrifuged at 160 g for 10 min and the recovered cells were resuspended, after three washings with Hanks' balanced salt solution (Gibco Labor...

show abstract

Section: Discussionsupporting

confidence: 59%

“…The causes of the development of SPTs may include genetic, hormonal, environmental and treatment-related factors (Cooper et al, 1989). Furthermore, longer survival times, owing to improved therapeutic results, increase the relative risk of a new tumour unrelated to the first (Cahan, 1977).…”

Section: Discussionmentioning

confidence: 99%

Identification of second malignancies on effusions and fine-needle aspirates using a panel of monoclonal antibodies

Mottolese¹,

Venturo

Rinaldi

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Radiation therapy is used routinely in LC patients with primary tumors as primary or adjuvant treatment, (42) which may enhance the risk of development of a second tumor in carriers. Among our 93 patients with MPT, 27 (29%) were treated with irradiation, six (6.5%) with chemotherapy and two (2.2%) with both modalities before the diagnosis of the second tumor.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene

Ziółkowska

Mosor

Wierzbicka³

et al. 2007

Cancer Science

View full text Add to dashboard Cite

The high incidence of multiple primary tumors (MPT) is a significant problem in head and neck tumor treatment. Recent studies suggest that carriers of heterozygous mutations in the NBS1 gene have an increased risk of malignant tumor development. The aim of our research was to assess the frequency of NBS1 mutations in patients with larynx cancer only (LC) and with MPT. The MPT group consisted of patients with one cancer localized to the larynx (primary or second) and another at another site. DNA from 175 patients with LC and 93 patients with MPT was analyzed using the single-strand conformation polymorphism method and direct sequencing. We found nine carriers of the I171V mutation among these 268 cancer patients and only one carrier among 500 population controls (0.2%). Four carriers of the I171V mutation were detected among 175 LC patients (2.3%) and five among 93 patients with MPT (5.4%). The frequencies of the I171V mutation carriers in LC and MPT patients were significantly higher than in controls (odds ratio D espite recent advances in the diagnosis and treatment of head and neck squamous cell carcinoma (HNSCC), the survival rate of patients with these tumors is not improving. One of the reasons for this is the frequent development of second primary tumors (SPT). Among HNSCC patients, the frequency of SPT occurrence ranges from 12 to 30% with a constant rate of 2-3% per year for patients who survive for more than 10 years.[(1-3) The first tumor is responsible for 15% of patient deaths, whereas the second tumor is the cause of death in 71% of cases. Squamous cell carcinoma is the predominant histological type of the second tumor. (4) In the etiology of multiple primary tumors (MPT) of the head and neck, tobacco and alcohol abuse ('condemned mucosa theory') are essential but are not the only causal factors.(5) It is supposed that genetic factors play a great role in the occurrence of the first tumor and, in addition, predispose the patient to the development of a second primary tumor. Because of reduced DNA repair capacity in patients who had two or more independent malignancies, (6) it has been suggested that alterations in DNA repair genes may play a significant role in head and neck tumor development.The NBS1 gene belongs to a group of double-strand break repair genes and is located on chromosome band 8q21.3. (7)(8)(9) Biallelic mutations in the NBS1 gene are responsible for Nijmegen breakage syndrome (NBS, OMIM 251260), classified to a group of chromosomal instability syndromes. NBS is a rare autosomal recessive disorder, occurring mainly in central and eastern Europe.(10) The most common is the homozygous 657del5 mutation, observed in 90% of NBS patients. The protein product of the NBS1 gene, nibrin (p95, NBS1), is a member of the MRE11-RAD50-nibrin complex, (7) which is involved in DNA double-strand break repair by homologous recombination or non-homologous end joining, meiotic recombination and the DNA damage response. (7,11) The MRE11-RAD50-nibrin complex is also required for activation of the damage c...

show abstract

“…Jones et al [13] in their study on "Second primary tumours in patients with head and neck squamous cell carcinoma" did not find association of radiotherapy for development of second primary in early cancers, whereas Cooper, Jay et al [18] based on the RTOG experience could find this risk as 10 % within 3 years, 15 % within 5 years and 23 % within 8 years respectively.…”

Section: Discussionmentioning

confidence: 93%

Oral Hybrid Verrucous Carcinoma: A Clinical Study

Gokavarapu

Tantravahi

Gundimeda

et al. 2014

Indian J Surg Oncol

View full text Add to dashboard Cite

Hybrid Verrucous Carcinoma is an uncommon tumour wherein Verrucous Carcinoma (VC) is coexisting with conventional Squamous Cell Carcinoma (SCC) within same maternal field. The heterogeneous nature, infrequency of occurrence and the difficulties associated with diagnosis and management of this tumor is discussed through a retrospective study. Patients of primary hybrid VC treated from Jan 2010 to May 2013 at a tertiary institute were analyzed on multivariate cox regression model. During the above mentioned period; 37 patients of hybrid VC were reported; 18(48.6 %) were male and 19(51.3 %) were female. Age ranged between 33 years to 78 years. Median follow up period was 32 months. T stage status and Stage grouping was not statistically significant for mortality (p value: 0.338). In the multivariate cox-regression model, the presence of second primary oral cancer was significantly associated with mortality, adjusted HR; 23.10 (95 % CI: 1.73, 307.65) (p=0.017). Tumour staging is often unreliable in predicting prognosis of hybrid VC, occurrence of second primary oral cancer and recurrence appears to be significant factors effecting prognosis.

show abstract

Second malignancies in patients who have head and neck cancer: Incidence, effect on survival and implications based on the RTOG experience

Cited by 361 publications

References 17 publications

Identification of second malignancies on effusions and fine-needle aspirates using a panel of monoclonal antibodies

Identification of second malignancies on effusions and fine-needle aspirates using a panel of monoclonal antibodies

Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene

Oral Hybrid Verrucous Carcinoma: A Clinical Study

Contact Info

Product

Resources

About