Second Malignancies in Retinoblastoma: The Real Problem

Williams, Basil K.; Schefler, Amy C

doi:10.5772/30664

Retinoblastoma: An Update on Clinical, Genetic Counseling, Epidemiology and Molecular Tumor Biology 2012

DOI: 10.5772/30664

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Second Malignancies in Retinoblastoma: The Real Problem

Basil K. Williams¹,

Amy C Schefler²

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2016

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Orbital medulloepithelioma in an adult patient: Radiation-induced second neoplasia?

Thottian

Benson

Kashyap

et al. 2016

Orbit

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Second cancers in survivors of hereditary retinoblastoma occur much more commonly than in the general population. This can be attributed both to the germline mutation of the RB gene and chemoradiation used for treatment of this paediatric cancer. Medulloepithelioma is an uncommon tumor of neuroectodermal origin, seen largely in the paediatric population and rarely reported in adults. Though the incidence of second malignancies is common in retinoblastoma, medulloepithelioma as a second malignancy in retinoblastoma survivors is rare, with only one case reported so far. Herein, we present a case of a 29-year-old patient presenting with medulloepithelioma of the right orbit, arising in the radiation field of previously treated retinoblastoma. This case was also peculiar in that though the origin of tumor was in the eyeball it had a very aggressive clinical course.

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Orbital medulloepithelioma in an adult patient: Radiation-induced second neoplasia?

Thottian

Benson

Kashyap

et al. 2016

Orbit

View full text Add to dashboard Cite

show abstract

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Second Malignancies in Retinoblastoma: The Real Problem

Cited by 1 publication

References 79 publications

Orbital medulloepithelioma in an adult patient: Radiation-induced second neoplasia?

Orbital medulloepithelioma in an adult patient: Radiation-induced second neoplasia?

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