Second malignant tumors in childhood cancer survivors.

Abstract

Review Sum maryThe growing incidence of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most unpleasant complications after cancer therapy is development of second malignant neoplasms. The risk of second malignancies is 2-3 times higher in childhood cancer survivors. The 20 year cumulative risk of secondary malignancies in 14193 chilhood cancer survivors followed for >5 years was 3.2 % . In this paper, the risk factors and development of improved therapies for second malignant neoplasms in childhood cancer survivors were reviewed. (Turk Arch Ped 2011; 46: 261-5)

Osteosarcoma After Hematopoietic Stem Cell Transplantation in Children and Adolescents: Case Report and Review of the Literature

“…In the Oncology Institute, Istanbul University, 189 osteosarcomas have been treated during 1990–2015, six of which were secondary osteosarcomas. Three had bilateral retinoblastoma, one had rhabdomyosarcoma, one had nasopharyngeal carcinoma, and one had myelodysplastic syndrome (MDS) as the first diagnosis …”

Occurrence of second primary cancer after curative resection of cholangiocarcinoma: a report of 5 cases

“…The frequency and type of secondary cancers may vary depending on the initial diagnosis and genetic predisposition. 1 Even some treatments for initial cancer, such as chemotherapy and radiation therapy, may increase the risk of development of another unrelated cancer in the future. 2 Over past 30 years, advances in the treatment for cancer have led to improvements in cancer cure rates and reduction of risk factors have increased longevity further.…”