Second neoplasm in patients with head and neck cancer

León, Xavier; Quer, Miquel; Diez, Santiago; Orús, César; López‐Pousa, Antonio; Burgués, Joaquim

doi:10.1002/(sici)1097-0347(199905)21:3<204::aid-hed4>3.0.co;2-7

Cited by 307 publications

(234 citation statements)

References 17 publications

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“…It is possible that distant metastases were underdiagnosed when they were synchronous with non-salvageable local or regional recurrences. The incidence of second tumors was lower than has been found in other studies, 12 possibly influenced by losses from follow-up and the higher disease stages in these patients. Monthly follow-up for long periods becomes impracticable for both the medical team and the patient.…”

confidence: 99%

Evolution of patients with squamous cell carcinoma of upper aerodigestive tract

2003

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CONTEXT: Local and regional recurrences are frequent in patients with squamous cell carcinoma of the upper aerodigestive tract and early diagnosis is important for salvage treatment. OBJECTIVE: To identify the period of highest risk for the development of recurrences after surgical treatment of squamous cell carcinoma of the upper aerodigestive tract, in spite of radical therapy, in order to plan the follow-up for these patients. TYPE OF STUDY: Cross-sectional, descriptive. SETTING: Department of Head and Neck Surgery/Otorhinolaryngology, Heliópolis Hospital (Hosphel), São Paulo, Brazil. PARTICIPANTS: A review was made of the hospital records of 889 patients with squamous cell carcinoma of the upper aerodigestive tract surgically treated between October 1977 and December 1996: 364 had oral cavity tumors, 107 had tumors of the oropharynx, 152 of the hypopharynx and 266, larynx tumors. The disease was stage I in 14 patients, stage II in 117, stage III in 352, stage IV in 397 and 9 patients were not staged. MAIN MEASUREMENTS: The interval between treatment and recurrence of disease was evaluated. The results were expressed as medians, quartiles (25% to 75%) and percentiles (10% to 90%). The annual incidence of recurrences and second tumors was calculated. RESULTS: Seventy-four percent of the recurrences were diagnosed within 18 months post-treatment. The local and regional recurrences and distant metastases showed medians of 270, 210 and 435 postoperative days respectively. The incidence of a second primary tumor varied from 2 to 3.1% a year. CONCLUSION: The majority of recurrences occurred within 18 months after the initial surgical treatment. The incidence of a second tumor remained stable after the first post-treatment year.

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confidence: 99%

Evolution of patients with squamous cell carcinoma of upper aerodigestive tract

2003

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“…[1][2][3][4] Second, there is substantial reduction in the patient's quality of life after radiotherapy of the oral cavity. [5][6][7][8][9][10] The data reported in the literature allow the hypothesis that early oral squamous cell carcinoma, stage T1-2, is adequately treated by en bloc resection with tumor-free margins [11][12][13][14][15] without subsequent radiotherapy, provided that a maximum of one lymph node has been invaded by the tumor and no rupture of the capsule has taken place.…”

mentioning

confidence: 99%

Surgical treatment of early oral carcinoma—Results of a prospective controlled multicenter study

Wolfensberger¹,

Zbaeren

Dulguerov

et al. 2001

Head & Neck

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Purpose of the study. To assess whether early stage (pT1-2,pN0-1) oral cavity carcinoma is adequately treated by radical surgical resection alone.Material and Methods. Prospective multicenter study. Of 105 patients with cT1-2 cN0-1 oral carcinoma treated in conformity with the study design, 12 had to be excluded because of tumorpositive margins or pN stage >N1. The remaining 93 patients were monitored for at least 2 years.Results. Seventeen patients had local or regional recurrence develop. In 12 of the 17 patients locoregional control was achieved by second treatment. Overall, the 4-year diseasespecific survival probability was 94%. Patients treated initially without selective neck dissection had significantly higher recurrence rates than those with neck dissection, although the survival probability was not adversely affected.Conclusions. Early (pT1-2, pN0-1) squamous cell carcinoma of the oral cavity is adequately treated by surgery alone, provided the resection margins are tumor free. On the basis of the presented data, we would also advocate routine selective neck dissection.

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“…In the present study, oesophageal cancer was the most common SPM in patients with HSCC, which is consistent with previous findings (4)(5)(6)10). Since oesophageal cancer shows a much poorer outcome than head and neck cancer, oesophageal cancer stage was found to be a crucial prognostic factor, including for HSCC patients with SPM.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

Yamamoto

Takano

Kondo

et al. 2018

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Abstract. Background Hypopharyngeal squamous cell carcinoma (HSCC) exhibits clinical manifestations that are different from other head and neck cancers. While it is less prevalent than other head and neck SCCs, accounting for 3-5% of all such malignancies, it carries a very poor prognosis (1-3). High mortality due to HSCC is caused not only by the high rates of nodal and early systemic metastases at presentation or during follow-up, but also the occurrence of second primary malignancies (SPMs) that are identified either simultaneously with the primary lesion (synchronous) or a period of time thereafter (metachronous). A recent study found that 17% of 2,063 patients with head and neck cancer involved SPMs, and that the overall survival rates of these patients were significantly lower than in those without SPMs (4). The head and neck, lung, and oesophagus are the most frequent areas of SPM development after an index head and neck cancer (4, 5). Many of the common risk factors for head and neck cancer, such as smoking, alcohol, aging, and poor oral hygiene, can increase the risk for SPM elsewhere in the body. Patients with HSCC in particular develop SPMs more frequently than those with other primary regions of head and neck cancer (5, 6); therefore, identifying the critical risk factors for this phenomenon is important for the earlier detection and prevention of multiple primary cancers. However, there have been few studies that focused on SPM in patients with HSCC. Hence, the present study aimed to analyse the clinical features and prevalence of synchronous and metachronous SPM in patients with HSCC, as well as to identify the risk factors associated with SPM occurrence and determine the causespecific mortality. Patients and MethodsPatients. A total of 136 patients (121 men and 15 women) with HSCC were diagnosed and treated between 2006 and 2015 at the

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Second neoplasm in patients with head and neck cancer

Cited by 307 publications

References 17 publications

Evolution of patients with squamous cell carcinoma of upper aerodigestive tract

Evolution of patients with squamous cell carcinoma of upper aerodigestive tract

Surgical treatment of early oral carcinoma—Results of a prospective controlled multicenter study

Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies

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