Second primary esophageal or lung cancer in patients with head and neck carcinoma in Taiwan: incidence and risk in relation to primary index tumor site

Chen, Min Chi; Chen, Ping Tsung; Chan, Chunghuang Hubert; Yang, Cheng‐Ta; Chen, Chih‐Cheng; Huang, Cih-En; Lu, Chang; Lee, Kuan Der

doi:10.1007/s00432-010-0865-0

Cited by 38 publications

(41 citation statements)

References 40 publications

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“…The development of second primary malignancy of esophagus, H&N region or lung in UADT cancer patients is high [4,5,7,22,23]. A nationwide study in Taiwan, where the prevalence of drinking alcohol, cigarette smoking and betel quid chewing is high, has shown that the standardized incidence ratio (SIR) of esophageal cancer in patients with head and neck cancer is significantly increased [4].…”

Section: Discussionmentioning

confidence: 99%

“…A nationwide study in Taiwan, where the prevalence of drinking alcohol, cigarette smoking and betel quid chewing is high, has shown that the standardized incidence ratio (SIR) of esophageal cancer in patients with head and neck cancer is significantly increased [4]. Supported by the concept of “field carcinogenesis” [2], cancer may develop synchronously or metachronously in the UADT.…”

Section: Discussionmentioning

confidence: 99%

“…Although the results were based on the hypothesis of the cancerization in respiratory and digestive axes [22], other investigation did not report the similar result [4]. In a nationwide database study [4], the incidence of second primary cancer is higher for esophageal cancer (SIR 8.71, 95% CI 7.55-10.01) than for lung cancer (SIR 1.56, 95% CI1.34-1.80) in laryngeal cancer patients.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

Chung

Liao

et al. 2013

BMC Gastroenterol

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BackgroundThe prevalence of esophageal neoplasia in head and neck (H&N) cancer patients is not low; however, routine esophageal surveillance is not included in staging of newly-diagnosed H&N cancers. We aimed to investigate the risk factors for synchronous esophageal neoplasia and the impact of endoscopy on management of H&N cancer patients.MethodsA total of 129 newly diagnosed H&N cancer patients who underwent endoscopy with white-light imaging, narrow-band imaging (NBI) with magnifying endoscopy (ME), and chromoendoscopy with 1.5% Lugol’s solution, before definite treatment were enrolled prospectively.Results60 esophageal lesions were biopsied from 53 (41.1%) patients, including 11 low-grade, 14 high-grade intraepithelial neoplasia and 12 invasive carcinoma in 30 (23.3%) patients. Alcohol consumption [odds ratio (OR) 5.90, 95% confidence interval (CI) 1.23-26.44], advanced stage (stage III and IV) of index H&N cancers (OR 2.98, 95% CI 1.11-7.99), and lower body mass index (BMI) (every 1-kg/m2 increment with OR 0.87, 95% CI 0.76-0.99) were independent risk factors for synchronous esophageal neoplasia. NBI with ME was the ideal screening tool (sensitivity, specificity, and accuracy of 97.3%, 94.1%, and 96.3%, respectively, for detection of dysplastic and cancerous esophageal lesions). The treatment strategy was modified after endoscopy in 20 (15.5%) patients. The number needed to screen was 6.45 (95% CI 4.60-10.90).ConclusionsNBI-ME surveillance of esophagus should be done in newly-diagnosed H&N cancer patients, especially those with alcohol drinking, lower BMI, and advanced stage of primary tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

Chung

Liao

et al. 2013

BMC Gastroenterol

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“…One of the major causes of death was the high incidence of second primary malignancies that jeopardized survival rates most in patients with early-stage disease. Previous studies indicated that patients with head and neck carcinoma had an increased risk of developing second primary malignancies, for which the head and neck regions, the esophagus and the lungs are the most usual sites (12,13). Survival after developing second primary cancers was poor, esophagus and lung being the worst (14 -16).…”

Section: Introductionmentioning

confidence: 99%

“…Thus far, it remains unclear whether there are ethnic and geographic disparities in the incidence and patterns of second primary malignancies following the oral cavity cancers. In the present study, we have analyzed the incidence and risk of second primary cancers using a population-based cohort of 26 166 patients with an initial diagnosis of oral cavity cancers in Taiwan, a prevalent area of betel-nut chewing with over 40% of head and neck cancers occurring in the oral cavity (13).…”

Section: Introductionmentioning

confidence: 99%

Incidence and Patterns of Second Primary Malignancies Following Oral Cavity Cancers in a Prevalent Area of Betel-nut Chewing: A Population-based Cohort of 26 166 Patients in Taiwan

Chen

Kuan

Huang

et al. 2011

Japanese Journal of Clinical Oncology

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Objective: The incidence of oral cavity cancers is increasing rapidly in South-East Asia, which may be attributable to tobacco smoking, alcohol and betel-nut chewing. However, the actual incidence and risk of second primary malignancies after oral cavity cancers have not been well established in this region. A population-based study was therefore conducted. Methods: Standardized incidence ratios and cumulative incidences were calculated for second primary cancers using the Taiwan Cancer Registry database for the period 1979-2003, which included 26 166 cases having an initial diagnosis of oral cavity cancers. Results: A 3.11-fold increase in risk for second cancer at all sites was observed after oral cavity cancers compared with the general population (standardized incidence ratio ¼ 3.11, 95% confidence interval: 2.97 -3.25). Of nine sites with excess risks of developing a second cancer, the frequency was highest in the oral/pharynx (60%), followed by lung (7.2%) and esophagus (5.5%). Second esophageal and lung cancers had a greater impact on survival compared with other types of second cancer. Notably, the risk excess was more prominent for patients with a follow-up interval of 1 year and a first primary cancer diagnosed at age of 40. These patients may justify closer surveillance. Conclusions: This is the largest population-based study with a homogeneous patient population focusing on oral cavity cancers within a high-incidence area. We found that oral cavity cancers are associated with an increased risk of nine second malignancies, which had a negative impact on survival.

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Second Cancer Incidence and Risk Factors in Patients With Salivary Gland Cancers

Kwon

Lee

Roh

et al. 2014

JAMA Otolaryngol Head Neck Surg

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Second primary esophageal or lung cancer in patients with head and neck carcinoma in Taiwan: incidence and risk in relation to primary index tumor site

Cited by 38 publications

References 40 publications

Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

Risk factors for second primary neoplasia of esophagus in newly diagnosed head and neck cancer patients: a case–control study

Incidence and Patterns of Second Primary Malignancies Following Oral Cavity Cancers in a Prevalent Area of Betel-nut Chewing: A Population-based Cohort of 26 166 Patients in Taiwan

Second Cancer Incidence and Risk Factors in Patients With Salivary Gland Cancers

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