Second primary head and neck tumor risk in patients with cervical cancer—SEER data analysis

Ragin, Camille; Taioli, Emanuela

doi:10.1002/hed.20663

Cited by 46 publications

(38 citation statements)

References 30 publications

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“…27,29,30 In our analysis restricted to women (data not shown), elevated risks were observed for both cervical cancer as a SPC following head and neck cancer (SIR 5 1.71, 95% CI 5 1.28-2.24) and head and neck cancer as a SPC following cervical cancer (SIR 5 1.91, 95% CI 5 1.64-2.22), especially among the youngest population. Similar analyses with the US SEER data also showed associations between first primary cervical cancer and second primary head and neck cancer, 31 and between first primary genital cancers (squamous cell carcinoma of cervix, cervical carcinoma in situ, vulva/vagina and anus) and second primary oral squamous cell carcinoma. 32 Although we observed various associations for SPCs in the head and neck, there are several limitations in our study.…”

Section: Table II -Numbers Of Cases (N) and Standardized Incidence Rasupporting

confidence: 70%

Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries

Chuang

Scélo

Tonita

et al. 2008

Intl Journal of Cancer

263

102

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The objective of the study was to assess the risk of second primary cancers (SPCs) following a primary head and neck cancer (oral cavity, pharynx and larynx) and the risk of head and neck cancer as a SPC. The present investigation is a multicenter study from 13 population-based cancer registries. The study population involved 99,257 patients with a first primary head and neck cancer and contributed 489,855 person-years of follow-up. To assess the excess risk of SPCs following head and neck cancers, we calculated standardized incidence ratios (SIRs) by dividing the observed numbers of SPCs by the expected number of cancers calculated from accumulated person-years and the age-, sex-and calendar period-specific first primary cancer incidence rates in each of the cancer registries. During the observation period, there were 10,826 cases of SPCs after head and neck cancer. For all cancer sites combined, the SIR of SPCs was 1.86 (95% CI = 1.83-1.90) and the 20-year cumulative risk was 36%. Lung cancer contributed to the highest proportion of the SPCs with a 20-year cumulative risk of 13%. Excess second head and neck cancer risk was observed 10 years after diagnosis with lymphohaematopoietic cancers. The most common SPC following a first primary head and neck cancer was lung cancer. However, the highest excess of SPCs was in the head and neck region. These patterns were consistent with the notion that the pattern of cancer in survivors of head and neck cancer is dominated by the effect of tobacco smoking and alcohol drinking. ' 2008 Wiley-Liss, Inc.Key words: head and neck cancer; second cancer A significant improvement in locoregional control of head and neck squamous cell carcinoma has been seen over the last decades, due to the introduction of new surgical techniques, improved radiotherapy techniques and the use of chemotherapy. However, 5-year relative survival from head and neck cancer has not increased greatly over the period of 1985-1994. 1,2 One of the reasons for the lack of improvement in overall survival is the frequent development of second primary cancers (SPCs) that occur more often in head and neck cancer patients than in patients with cancers of other sites 3 and lead to poor prognosis. [4][5][6] Head and neck cancers (oral cavity, pharynx and larynx) comprise around 5% of all cancer cases worldwide and result in 6% of cancer deaths in men and 3% in women.7 SPCs after head and neck cancers are mostly found in the aerodigestive tract, including the lung and esophagus, which leads to a significant decrease in survival. 5 In contrast to the overall 5-year survival rate for head and neck cancer patients of approximately 50%, the 5-year survival rate in head and neck cancer patients who developed SPC was around 20% after the SPC was diagnosed. 4,5 The 5-year survival rates after SPC diagnosis were above 30% if the SPC was also a head and neck cancer and decreased to 8% if the SPC was outside the head and neck area.

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Section: Table II -Numbers Of Cases (N) and Standardized Incidence Rasupporting

confidence: 70%

Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries

Chuang

Scélo

Tonita

et al. 2008

Intl Journal of Cancer

263

102

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“…Moreover, we found even stronger protective associations for disease-specific events including cancer death for HPV16-positive oropharyngeal cancers compared to their HPV16-negative counterparts. A lower risk of secondary primary cancers has also been attributed to HPV-associated HNSCC [27]. Although a subset of cases included in this study presented with second or higher primary HNSCC, excluding or adjusting for subsequent primaries did not change the observed survival associations with HPV.…”

Section: Discussionmentioning

confidence: 71%

Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma Survival: A Comparison by Tumor Site and Initial Treatment

Salazar

Smith

Garg

et al. 2013

Head and Neck Pathol

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Recent evidence suggests that human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) patients have better survival than HPV-negative patients. However, it is unclear if similar patterns for survival exist across different tumor sites, and whether HPV-associated prognosis is modified by type of treatment. We prospectively tested 222 histologically confirmed HNSCC primary tumors for HPV DNA by PCR and HPV E6/E7 RNA by RT-PCR prior to treatment at a large urban health center. Cox proportional hazard ratio models were constructed to assess HPV-associated differences in overall and disease-specific survival adjusting for clinical and demographic covariates. HPV detection varied significantly by primary HNSCC tumor site, from 35 % for oropharynx, to 25 % for hypopharynx, 5 % for larynx, and 3 % for oral cavity (p \ 0.0001), with HPV16 accounting for the majority (95 %) of HPV-positive tumors. The hazard-risk of overall and disease-specific death comparing HPV16-positive versus negative oropharyngeal HNSCC was reduced by 74 and 89 %, respectively (p values \ 0.05), and was independent of other prognostic indicators; no statistically significant changes in outcomes were observed for non-oropharyngeal HNSCC sites. Prediction of overall survival was better with combined DNA and RNA HPV16 positive PCR detection. There was no difference in HPV16-associated survival whether patients received either surgery or (chemo)radiotherapy as their initial treatment modality. Improved HPV-associated HNSCC survival is limited to Electronic supplementary material The online version of this article

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“…The risk for HPV-positive HNSCC increases with increasing numbers of both oral and vaginal sexual partners, a history of genital warts, and a younger age at first intercourse (Schwartz et al, 1998;Kreimer et al, 2004). In a recent analysis of the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) data from 1973-2002, a diagnosis of cervical cancer was found to confer an increased risk for development of a second primary oropharyngeal cancer (oropharynx SIR = 2.7; tonsil SIR = 3.1), without increasing the risk of developing oral cavity or other cancers (Rose Ragin and Taioli, 2008). Additionally, an increased risk of tonsillar cancer has been observed in the husbands of women with documented history of cervical dysplasia or cancer (Hemminki et al, 2000).…”

Section: Risk Factors For Hpv-positive Hnsccmentioning

confidence: 99%

Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

2009

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Over the past 20 years, high-risk human papillomavirus (HPV) infection has been established as a risk factor for developing head and neck squamous cell carcinoma, independent of tobacco and alcohol use. In particular, HPV is strongly associated with the development of oropharyngeal cancer and a small minority of oral cavity cancers. In this review, we summarize what is currently known about the biology of HPV, the mechanisms by which it effects malignant transformation, and the potential impact of HPV status on the clinical management of persons with head and neck cancer.

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Second primary head and neck tumor risk in patients with cervical cancer—SEER data analysis

Cited by 46 publications

References 30 publications

Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries

Risk of second primary cancer among patients with head and neck cancers: A pooled analysis of 13 cancer registries

Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma Survival: A Comparison by Tumor Site and Initial Treatment

Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: Recent Evidence and Clinical Implications

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