Second Primary Malignant Neoplasms: A Clinicopathological Analysis from a Cancer Centre in India

Hulikal, Narendra; Ray, Sujoy; Joseph, Thomas; Fernandes, Donald J

doi:10.7314/apjcp.2012.13.12.6087

Cited by 26 publications

(22 citation statements)

References 27 publications

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“…[13][14][15][16] This study was in line with respect to the distribution of synchronous vs. metachronous malignancies as reported in the literature. [16][17][18] The available retrospective studies from various regions of India suggest higher percentage of metachronous malignancies compared to synchronous malignancy. 18,19 The distribution of synchronous and metachronous malignancies across various retrospective analyses is presented in (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…14 According to existing literature the median/mean age of primary malignancy diagnosis in this study was comparable to the age reported across various studies (>50 years). 17,18 The potential occurrence of multiple primary malignancies should always be considered during diagnostic evaluation. While screening procedures will help detect any early-stage tumors, regular follow-up strategies will help in reducing the mortality burden from second primary malignancies.…”

Section: Discussionmentioning

confidence: 99%

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Double malignancies: a clinicopathological and outcomes retrospective analysis from a tertiary cancer referral centre in South India

Nandennavar¹,

Angadi²,

Karpurmath³

et al. 2019

Int J Res Med Sci

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Background: The presence of second synchronous or metachronous primary malignancies in a cancer patient is not a rare phenomenon. Our study is an endeavour to present data on the frequency, types, and outcomes of double primary malignancies in Indian cancer patients.Methods: This was a retrospective study conducted in 28 cancer patients diagnosed with histologically confirmed double malignancy. Retrospective data of the cancer site, patient’s age at the presentation, gender, type of cancer (synchronous/metachronous), treatment, and outcome were recorded from patients presented with double malignancies from January 2012 to January 2019.Results: Among 28 patients (18 females; 10 males) with multiple primary malignancies, 10 (35.7%) and 18 patients (64.3%), respectively, had synchronous and metachronous primary malignancies. Overall, breast, gynecological, head, and neck cancer were the most common primary malignancies. Gastrointestinal tract, breast, and lung cancer emerged to be the most common second primary malignancy sites. Squamous cell carcinoma (SCC) and invasive ductal carcinoma (IDC) were the most common histopathological types of double malignancies. The majority of the patients received appropriate treatment for both the malignancies.Conclusions: Data from the present study clearly suggest that the occurrence of second primary malignancy is not rare in Indian cancer patients. The double malignancies can occur at any stage and for any type of cancer. Hence, we wish to highlight that the clinician should always be aware of the possibility of developing second malignancy either during evaluation or in follow up of a patient with malignancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Double malignancies: a clinicopathological and outcomes retrospective analysis from a tertiary cancer referral centre in South India

Nandennavar¹,

Angadi²,

Karpurmath³

et al. 2019

Int J Res Med Sci

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“…In general, the incidence of double primary malignancy is not considered rare [1] [2]; the risk of second cancer has been 10% at 20 years and 26% at 30 years following Hodgkin disease treatment [3], and 3.8%. At 10 years versus 7% at 15 years for patients treated with doxorubicin-based regimens for breast cancer [4].…”

Section: Introductionmentioning

confidence: 99%

Multiple Primary Malignancies: Metastatic Renal with Early Breast and Endometrial Cancers: A Case Report

Rayan¹,

Ashraf²,

Bakri³

2018

JCT

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Double primary malignancies could be divided into two categories, depending on the interval between tumor diagnoses. A secondary malignancy could be defined as a new cancer that has occurred as a result of previous treatment with radiation or chemotherapy. Second primary malignancy can occur at any age but it's commonly at old age. A 46 premenopausal female patient presented to our outpatient clinic complaining from a mass in her right breast, routine metastatic work-up for distant metastasis declared multiple hepatic metastases, RT renal mass, and bone metastases. Palliative radiotherapy to tender and weight bearing sites followed by 4 cycles of systemic chemotherapy FEC regimen were received. Tru-cut needle biopsy from renal mass detected renal cell carcinoma of clear cell type, the patient started sunitinib and tamoxifen with bisphosphonate (Zoledronic acid), assessment of the response revealed reduction of the size and number of HFLs, and the size of renal mass, so the patient was decided to do cytoreductive nephrectomy and then continued on TAM and sunitinib. Collectively, due to the rising incidence of multiple primary malignancies, further studies should be done not only for better clinical evaluation and treatments but also for accurate determination of possible causes, pathogenesis, effective managements and screening programs.

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“…The occurrence of second malignancy in a patient with a known malignant tumour is not very uncommon [1]. Based on the time gap between the detection of two malignancies, these are labelled as synchronous or metachronous [2].…”

Section: Introductionmentioning

confidence: 99%

CML as Part of Dual Malignancies—A Retrospective Analysis: Possible Mechanisms and Review of Literature

Sahu

Yanamandra

Bal

et al. 2015

Indian J Hematol Blood Transfus

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Introduction of imatinib has changed the outlook of chronic myeloid leukaemia (CML) patients with overall survival approaching general population. Long term survival in CML patients has provided an opportunity to better study natural history and long term complications of disease as well as the treatment modalities. To study the occurrence and association of other malignancies with their outcomes in patients with CML. This is a single centre retrospective study. All CML patients case records registered with haematology clinic of a tertiary care centre in North India from 2001 to 2014 were perused and evaluated for dual malignancies. Those patients with dual malignancies were personally examined and interviewed if alive. Out of 1677 patients, 15 cases had co-existent malignancies. Four of fifteen cases of dual malignancies had CML as secondary cancer. Three had synchronous and rest 12 patients had metachronous malignancies. Only one patient was in accelerated phase, rest all were in chronic phase. Median age of the dual malignancy cases was 50 years (25-66 years), much younger than reported in west. The initial dose of imatinib was 400 mg OD in all except one.We did not find any causal association between CML or imatinib therapy with development of secondary tumours. Interestingly in this series, incidence of CML as secondary or synchronous malignancy was higher than earlier published studies.

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Second Primary Malignant Neoplasms: A Clinicopathological Analysis from a Cancer Centre in India

Cited by 26 publications

References 27 publications

Double malignancies: a clinicopathological and outcomes retrospective analysis from a tertiary cancer referral centre in South India

Double malignancies: a clinicopathological and outcomes retrospective analysis from a tertiary cancer referral centre in South India

Multiple Primary Malignancies: Metastatic Renal with Early Breast and Endometrial Cancers: A Case Report

CML as Part of Dual Malignancies—A Retrospective Analysis: Possible Mechanisms and Review of Literature

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