Second primary tumors and myeloperoxidase expression in buccal mucosal squamous cell carcinoma

Lai, Wei-Ming; Chen, Chien‐Chou; Lee, Jang-Hwa; Chen, Chia‐Jung; Wang, Jyh-Seng; Hou, Yu‐Yi; Liou, Horng-Huei; Chen, Hung-Chih; Fu, Ting‐Ying; Lee, Yi-Cheng; Ger, Luo‐Ping

doi:10.1016/j.oooo.2013.06.018

Cited by 12 publications

(9 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lai et al. postulated that prolonged exposure to reactive oxygen species generated when chewing betel quid, smoking tobacco, and drinking alcohol may lead to malignant transformation of epithelial cells at several sites of the upper digestive tract . The rate and the common subsites of second primary tumors in this study were similar to those of oral SCC in Lai's study .…”

Section: Discussionsupporting

confidence: 75%

“…Regional recurrence was defined as cancer developing in the cervical lymph nodes within 5 years . A second primary tumor was defined as a second tumor of identical pathological type occurring more than 5 years after therapy for the primary tumor, one of a different pathological type, or one separated from the initial primary tumor by >2 cm of clinically normal epithelium . The Institutional Review Board of Kaohsiung Veterans General Hospital approved this study (IRB number: VGHKS97‐CT2‐08, 2008).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological study of lip cancer: a retrospective hospital‐based study in Taiwan

Tseng

Liou

Ger

et al. 2017

APMIS

View full text Add to dashboard Cite

To evaluate the clinicopathological characteristics, high-risk lifestyle factors (HRLF: chronic exposure to sun, betel quid, alcohol, and tobacco), and prognostic factors of lip cancer. The hospital records of patients with pathologically confirmed lip squamous cell carcinoma (LSCC, n = 112) and lip basal cell carcinoma (LBCC, n = 21) were reviewed. Differences in clinicopathological characteristics between LSCC and LBCC, upper and lower lip, and status of second primary tumors were compared by chi-square test and logistic regression. The prognostic factors for LSCC were analyzed by Cox regression. Compared with LBCC patients, LSCC patients were men-predominant (p < 0.001), had younger ages at onset (p < 0.001), and higher rates of lower lips involvement (p < 0.001) and HRLFs. Patients with second primary tumors were highly associated with lower lip cancer involvement (adjusted odds ratio = 2.91, p = 0.03). Patients with lower lip cancer had more HRLFs with an increasing linear trend (p = 0.004). The poorer prognostic factors of LSCC for disease-specific survival were advanced stage III/IV [crude hazard ratio (CHR) = 11.16, p < 0.001], tumor dimension >4 cm (CHR = 8.19, p = 0.006), lymph node involvement (CHR = 11.48, p < 0.001), and recurrence (CHR = 3.96, p = 0.01); whereas for disease-free survival were moderately to poorly differentiated LSCC (CHR = 4.97, p = 0.002) and alcohol consumption (CHR = 3.13, p = 0.04). LSCC and lower lip cancer were highly associated with HRLFs.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Methodsmentioning

confidence: 99%

Clinicopathological study of lip cancer: a retrospective hospital‐based study in Taiwan

Tseng

Liou

Ger

et al. 2017

APMIS

View full text Add to dashboard Cite

show abstract

“…Lai et al. reported that a higher expression of MPO in buccal mucosal SCC was a risk factor for second primary tumors, and that a high expression level was usually related to a high degree of DNA damage, indicating cancer progression .…”

Section: Discussionmentioning

confidence: 99%

“…MPO has also been identified in other cancer cell types including gynecologic (39), colorectal (40), and buccal mucosal SCC (27). Lai et al reported that a higher expression of MPO in buccal mucosal SCC was a risk factor for second primary tumors, and that a high expression level was usually related to a high degree of DNA damage, indicating cancer progression (11).…”

Section: Discussionmentioning

confidence: 99%

“…Data on demographics, high‐risk lifestyle factors, cancer cell pathological morphology, the grade of cancer cell differentiation (well, moderate, and poor) in pathological reports, TNM stage, local and regional recurrence, survival status, second primary tumors, and recurrence were collected from the patients’ hospital records. A second primary tumor was defined as a second tumor of identical pathological type occurring more than 5 years after therapy for the primary tumor, one of a different pathological type, or one separated from the initial primary tumor by >2 cm of clinically normal epithelium . The patients’ survival status was confirmed by hospital records.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma

Tseng

Liou

et al. 2018

APMIS

Self Cite

View full text Add to dashboard Cite

The aim of this study was to investigate the associations among the immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) tissues and the clinicopathological characteristics, and prognostic factors in patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were examined in 76 LSCC tissue samples using immunohistochemical staining on tissue microarray slides, and compared to those in normal lip mucosa adjacent to venous lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), and recurrent tumors. Associations between immunoexpression levels and clinicopathological characteristics were analyzed using the Student's t-test. The prognostic factors were analyzed using Cox regression. The immunoexpression levels of Mn-SOD, GPx, and MPO were significantly different among the normal controls, NTACTs, tumors, and recurrent tumors (Mn-SOD: p = 0.001, GPx: p < 0.001, MPO: p < 0.001). Lower lip cancer was associated with higher Mn-SOD immunoexpression levels (p = 0.04) and probably indicated higher oxidative stress. Lymph node involvement with a lower immunoexpression level of MPO (p = 0.007) indicated compensatory mechanism to attenuate oxidative damage. A low Mn-SOD immunoexpression level was borderline significantly associated with a worse prognosis for disease-specific survival, and it was probably related to a lower capacity for coping with oxidative stress.

show abstract

Immune System-Related Biomarkers as a Tool for Diagnosis in Oral Cancer

Arroyo

Pérez‐Jardón

Carrión

et al. 2022

Handbook of Cancer and Immunology

View full text Add to dashboard Cite

Second primary tumors and myeloperoxidase expression in buccal mucosal squamous cell carcinoma

Cited by 12 publications

References 63 publications

Clinicopathological study of lip cancer: a retrospective hospital‐based study in Taiwan

Clinicopathological study of lip cancer: a retrospective hospital‐based study in Taiwan

The association between immunoexpression levels of oxidant and antioxidant enzymes and lip squamous cell carcinoma

Immune System-Related Biomarkers as a Tool for Diagnosis in Oral Cancer

Contact Info

Product

Resources

About