Second Primary Tumours of the Head and Neck are not Associated ith Adverse Overall Survival in Oral Sccs

Farhadieh, Rostam Dariush; Otáhal, Petr; Taghavi, Kiarash; Salardini, Arash; Russell, Pamela J.; Smee, Robert

doi:10.4172/1948-5956.1000053

Cited by 6 publications

(8 citation statements)

References 28 publications

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“…Most authors consider that the outcome of the SPT is more frequent during the first 3 years; however, in our research, with a 12-year follow-up, the outcome risk of a [14,16]. It is considered that between 3 and 4 cases of second neoplasm appear per year; the most frequent locations are head and neck subsectors, lungs, and esophagus; less frequent locations are colon, genitourinary system, pancreas, and breast [9].…”

Section: Discussionmentioning

confidence: 65%

Prognostic impact of second primary tumors in head and neck cancer

Patrucco¹,

Aramendi²

2015

Eur Arch Otorhinolaryngol

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The incidence of Second Primary Tumors in the upper aerodigestive tract varies from 5 to 30 %. Most of them are located either in the same anatomical region or in the lungs, and are related to a poor overall survival. Our objective is to assess the incidence of Second Primary Tumors, factors related to its outcome, frequent associations, and impact on overall survival. 27 patients with Second Primary Tumors were reviewed out of 307 with head and neck cancer, between 2002 and 2011. Patients had a minimum follow-up period of 3 years, or until their death after the last treatment. Sex: 85.2 % were male; male:female ratio of 23:4. The mean age of appearance for the primary tumor was 66.8 years. Only 1 patient had a synchronous Second Primary Tumor, while 26 had metachronous Second Primary Tumors. Second neoplasms were grouped into synchronous and metachronous for statistical analysis. The following parameters were considered: age at diagnosis of the first tumor, gender, smoking and persistence of the habit, primary tumor's location in the larynx, association between two squamous cell carcinomas (index and second primary tumor), and radiotherapy for the primary tumor. The incidence of Second Primary Tumors was 8.79 %. Overall survival of metachronous tumors was 95 months (7.9 years). The primary tumor's location that prevailed when developing a Second Primary Tumor was the larynx. Regarding the histology, the most common association was head and neck squamous cell carcinoma with head and neck squamous cell carcinoma (9 patients). The Second Primary Tumor was the cause of death in 51.9 % of the patients and its most frequent location was the lungs. 19 patients underwent radiotherapy. Second Primary Tumors are common in the head and neck. The authors would like to enforce the importance of an extended follow-up, since second neoplasms worsen considerably the patient's prognosis. Patients who keep on smoking after treatment decrease even more their overall survival.

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Section: Discussionmentioning

confidence: 65%

Prognostic impact of second primary tumors in head and neck cancer

Patrucco¹,

Aramendi²

2015

Eur Arch Otorhinolaryngol

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“…Ova hipoteza ima podlogu u činjenici izlaganja zahvaćenog organa istom kancerogenu kontinuirano kroz duže vrijeme 2 . Genetska preosjetljivost, imunodeficijencija kao i mogući učinak liječenja primarnog tumora prvenstveno radiokemoterapijom također može imati utjecaj na promjenu sluzničkog epitela kao preduvjet nastanka polja kancerizacije [8][9][10][11][12][13] . Organski sustavi u kojima se može naći ovaj fenomen osim aerodigestivnog trakta su i genitalni, probavni kao i koža [1][2][3][4][5] .…”

Section: Uvodunclassified

“…karcinom ovisi o nizu za sada nepoznatih čimbenika [3][4][5][6] . Kancerogen koji je djelovao dovoljno dugo promijenio je sluznicu kod genetski predisponiranih osoba, tako da unatoč prestanku njegovog djelovanja na sluznici koja je obilježena poljima kancerizacije u bilo kojem vremenskom odmaku od inicijalnog tumora može započeti nastanak novog, drugog ili čak trećeg primarnog tumora [1][2][3][4][5][6][7][8][9][10][11][12][13] . Sva ova saznanja moraju imati za cilj trajno praćenje pacijenata kod kojih postoje organski sustavi obilježeni poljima kancerizacije kako bi se na vrijeme otkrio i pravovremeno liječio nov tumor na istom organu ili organskom sustavu.…”

Section: Uvodunclassified

“…Kombinacija dvaju primarnih tumora javlja se u 3 -55 %, tri u 0,5 % a četiri u 0,3 % pacijenata [1][2][3][4][5][6][7][8] . Pod utjecajem poznatih kancerogena u pločastom epitelu sluznice glave i vrata postoje područja sluznice s velikim brojem genskih abnormalosti koje se izmjenjuju s područjima sluznice s genski reguliranim ciklusima, što se naziva "mulitistep karcinogeneza" [12][13][14][15] . Ovakva progresivna akumulacija genskih abnormalnosti podloga je za nastanak drugih primarnih tumora godinama nakon prestanka izlaganju kancerogenu koji je doveo do početnih promjena.…”

Section: Raspravaunclassified

“…Ovisno o vremenu pronalaska drugog metakronog tumora ono iznosi prosječno 31 -43 mjeseca nakon otkrića primarnog tumora [22][23][24][25][26][27] . Činjenica o pojavi sinkronih, a poglavito metakronih tumora larinksa, potvrđuje da je sluznica larinksa jedno jedinstveno polje kancerizacije, što čini podlogu za nastanak novog tumora [1][2][3][4][5][6][7][8][9][10][11][12][13] .…”

Section: Raspravaunclassified

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Metakroni karcinom larinksa – prikaz slučaja

Grabovac

Grabovac²,

Puharić³

et al. 2019

Med. Flum. (Online)

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Sažetak. Cilj: Ukazati na potrebu trajnog praćenja pacijenata kod kojih je zbog karcinoma učinjena parcijalna laringektomija. Prikaz slučaja: Prikazali smo pacijenta koji je u vremenskom razmaku od dvadeset godina tri puta imao karcinom larinksa. 1982. godine učinjena je parcijalna laringektomija. Drugi primarni tumor nastao je na sluznici ostatka larinksa 2000. godine, kada je učinjena traheotomija i laringofisura s ekscizijom tumora. Treće javljanje tumora bilo je 2002. godine kada je učinjena retraheotomija i totalna laringektomija. U sva tri javljanja radilo se o planocelularnom karcinomu. Pacijent je od 2000. godine bio pod redovitom kontrolom, a preminuo je 2013. godine u dobi od 85 godina. Zaključak: Pojava planocelularnog karcinoma larinksa moguća je godinama nakon uspješnog liječenja početnog tumora. Objašnjenje nalazimo u ostatku sluznice koja je obilježena poljima kancerizacije, što čini podlogu za nastanak novih tumora. Ključne riječi: metakroni karcinom larinksaAbstract. Aim: To point out the need for permanent monitoring of patients with partial laryngectomy due to cancer. Case report: We have shown a patient who has had the laryngeal cancer three times at intervals of twenty years In 1982, a partial laryngectomy was performed. The second primary tumour was formed on the mucosa of the rest of the larynx in 2000, when the tracheotomy and laryngofissure were performed. The third tumour incidence was in 2002, when retracheotomy and total laryngectomy were performed. In all three cases, there was the case of a planocellular carcinoma. The patient was regularly checked-up since 2000, but he passed away in 2013 at the age of 85. Conclusion: The appearance of the laryngeal planocellular carcinoma is possible years after the successful treatment of the primary tumour. The explanation is found in the remains of the mucosa, which is marked by the field of cancerisation, which is the basis for the incidence of new tumours.

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