Second trimester amniocentesis in assisted conception versus spontaneously conceived twins

Anastasakis, Eleftherios; Papantoniou, Nikolaos; Mesogitis, S.; Antsaklis, Aris

doi:10.1016/j.fertnstert.2008.03.080

Cited by 19 publications

(25 citation statements)

References 58 publications

(50 reference statements)

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“…The issue of the safety of invasive procedures is of paramount importance for patients with twin pregnancies following ART. In an earlier study we observed a similar pregnancy loss rate following amniocentesis in ART and spontaneously conceived twins [7]. Several studies have reported on the pregnancy loss rate after CVS in twins [3, 5, 8 -15].…”

Section: Introductionsupporting

confidence: 71%

Chorionic Villus Sampling in Assisted Versus Spontaneous Conception Twins

Daskalakis¹,

Antsaklis²,

Gourounti³

et al. 2015

Ultraschall in Med

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To compare the outcome of chorionic villus sampling (CVS) in twin pregnancies following assisted reproduction technology (ART) versus twins that have been conceived spontaneously. Retrospective analysis of dichorionic twin pregnancies that underwent CVS between 1986 and 2013 at our department which is a tertiary center for fetal medicine. 32 twin pregnancies after ART and 130 spontaneously conceived twin pregnancies, which underwent CVS, were analyzed. No difference was observed in the pregnancy loss rate between the two groups (0 % in the ART group vs. 3 % in the spontaneous twins group). The rate of preterm delivery before 28 weeks was higher in the ART group (18.8 %) compared to the control group (1.6 %). The perinatal mortality rate was similar in the two groups. The pregnancy loss rate following CVS is similar in ART twins and in spontaneous twins. However, the risk of prematurity before 28 weeks is significantly higher in the ART group.

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Section: Introductionsupporting

confidence: 71%

Chorionic Villus Sampling in Assisted Versus Spontaneous Conception Twins

Daskalakis¹,

Antsaklis²,

Gourounti³

et al. 2015

Ultraschall in Med

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“…35,36 High FPR potentially posts great mental stress to pregnant women with IVF twins, because the risk of procedure-related fetal loss in ART twin pregnancies is more than doubled comparing to singleton pregnancy. 37,38 In contrast, NIPT showed an extremely low FPR (0% with the 95%CI from 0% to 0.70%) and high PPV in this study and can be performed at early pregnancy; therefore, it has the potential to significantly reduce the risk of unnecessary invasive procedure and increase the number of affected fetus that can be identified. Importantly, more precise candidate for prenatal diagnosis means that genetic counseling and clinical intervention can be offered to women who really need it.…”

Section: Discussionmentioning

confidence: 53%

“…Ultrasound NT is widely used in prenatal screening in ART twin pregnancy, even though the detection rate is only about 70% with a 5% FPR . High FPR potentially posts great mental stress to pregnant women with IVF twins, because the risk of procedure‐related fetal loss in ART twin pregnancies is more than doubled comparing to singleton pregnancy . In contrast, NIPT showed an extremely low FPR (0% with the 95%CI from 0% to 0.70%) and high PPV in this study and can be performed at early pregnancy; therefore, it has the potential to significantly reduce the risk of unnecessary invasive procedure and increase the number of affected fetus that can be identified.…”

Section: Discussionmentioning

confidence: 71%

Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

et al. 2016

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“…Pregnancies conceived through ART may be considered (particularly) ‘precious’ pregnancies and hence be managed differently, either due to healthcare provider factors or women's preferences . ART pregnancies are known to be associated with a higher risk of congenital malformations, and in particular of congenital heart defects (CHD) .…”

Section: Introductionmentioning

confidence: 99%

Is the probability of prenatal diagnosis or termination of pregnancy different for fetuses with congenital anomalies conceived following assisted reproductive techniques? A population‐based evaluation of fetuses with congenital heart defects

Tararbit

Lelong

Jouannic

et al. 2015

BJOG

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Objective To compare the probability of prenatal diagnosis (PND) and termination of pregnancy for fetal anomaly (TOPFA) between fetuses conceived by assisted reproductive techniques (ART) and spontaneously-conceived fetuses with congenital heart defects (CHD).Design Population-based observational study.Setting Paris and surrounding suburbs.Population Fetuses with CHD in the Paris registry of congenital malformations and cohort of children with CHD (Epicard).Methods Comparison of ART-conceived and spontaneously conceived fetuses taking into account potential confounders (maternal characteristics, multiplicity and year of birth or TOPFA).Main outcome measures Probability and gestational age at PND and TOPFA for ART-conceived versus spontaneously conceived fetuses.Results The probability of PND (28.1% versus 34.6%, P = 0.077) and TOPFA (36.2% versus 39.2%, P = 0.677) were not statistically different between ART-conceived (n = 171) and spontaneously conceived (n = 4620) fetuses. Estimates were similar after adjustment for potential confounders. Gestational age at PND tended to be earlier for ART fetuses (23.1 versus 24.8 weeks, P = 0.05) but no statistical difference was found after adjustment for confounders. Gestational age at TOPFA was comparable between ART-conceived and spontaneously conceived fetuses.Conclusions In our population, ART conception was not significantly associated with the probability of PND or TOPFA for CHD. One implication of our results is that live births may be adequate for assessing the overall risk of CHD related to ART. However, total prevalence, in particular of severe CHD, would not be adequately assessed if TOPFA are not included.Keywords Assisted, congenital, epidemiology/population-based, heart defects, prenatal diagnosis, reproductive techniques, termination of pregnancy for fetal anomaly.Please cite this paper as: Tararbit K, Lelong N, Jouannic J-M, Goffinet F, Khoshnood B on behalf of the EPICARD Study Group. Is the probability of prenatal diagnosis or termination of pregnancy different for fetuses with congenital anomalies conceived following assisted reproductive techniques? A population-based evaluation of fetuses with congenital heart defects. BJOG 2015;122:924-931. †

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Second trimester amniocentesis in assisted conception versus spontaneously conceived twins

Cited by 19 publications

References 58 publications

Chorionic Villus Sampling in Assisted Versus Spontaneous Conception Twins

Chorionic Villus Sampling in Assisted Versus Spontaneous Conception Twins

Noninvasive prenatal testing (NIPT) in twin pregnancies with treatment of assisted reproductive techniques (ART) in a single center

Is the probability of prenatal diagnosis or termination of pregnancy different for fetuses with congenital anomalies conceived following assisted reproductive techniques? A population‐based evaluation of fetuses with congenital heart defects

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