Second trimester fetal death caused by varicella‐zoster virus infection

Tanimura, Kenji; Kojima, Nobue; Yamazaki, Takashi; Semba, Shuho; Yokozaki, Hiroshi; Yamada, Hideto

doi:10.1002/jmv.23531

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Varicella is unlike other TORCH infections in that the highest level of transmission to the fetus occurs in the second trimester, with 2% risk at 13-20 weeks (76). First-or thirdtrimester infection rarely leads to hydrops and demise (76)(77)(78). However, new onset of varicella at term can lead to neonatal demise.…”

Section: Varicellamentioning

confidence: 99%

How Does Imaging of Congenital Zika Compare with Imaging of Other TORCH Infections?

et al. 2017

View full text Add to dashboard Cite

The acronym TORCH is used to refer to congenital infections, such as toxoplasmosis, other infections (such as syphillis, varicella-zoster, and parvovirus B19), cytomegalovirus, and herpes simplex virus. The classic findings in patients with TORCH infections include rash in the mother during pregnancy and ocular findings in the newborn. Zika virus has emerged as an important worldwide congenital infection. It fits well with other congenital TORCH infections since there is a rash in the mother and there are commonly ocular abnormalities in the newborn. TORCH infections are recognized to have neurologic effects, such as ventriculomegaly, intraventricular adhesions, subependymal cysts, intracerebral calcifications, and microcephaly; however, the Zika virus is intensely neurotropic. Thus, it targets neural progenitor cells, leading to a more severe spectrum of central nervous system abnormalities than is typically seen in other TORCH infections, while relatively sparing the other organ systems. In this review, nonspecific findings of congenital infections initially will be described, then individual TORCH infections will be described and compared with the imaging findings associated with congenital Zika virus infection. For the radiologist, awareness of imaging features of common congenital infections may facilitate early diagnosis and may, at times, lead to prompt initiation of therapy. Online supplemental material is available for this article.

show abstract

Section: Varicellamentioning

confidence: 99%

How Does Imaging of Congenital Zika Compare with Imaging of Other TORCH Infections?

et al. 2017

View full text Add to dashboard Cite

show abstract

“…22 Because of the implementation of Rubella vaccination programs, Coxsackie viruses (particularly B3 23 and B4 24 ) have since emerged as relatively more commonly reported viruses, particularly in cases with early cardiac dysfunction and NIH 24 if not as major attributable causes of intrauterine fetal demise. 25 Other viral etiologies such as Varicella Zoster 26,27 and Adenovirus 28,29 have remained extremely rare. Coxsackie, Varicella Zoster, and Adenovirus have never been encountered by the authors.…”

Section: Infectious Causes Of Nonimmune Hydropsmentioning

confidence: 99%

Pathology of the Stillborn Infant for the General Pathologist

Faye-Petersen

Heller²

2015

Advances in Anatomic Pathology

View full text Add to dashboard Cite

As the information obtained from previable fetal and stillbirth autopsies is used not only to explain the loss to the parents, but for future pregnancy planning, general pathologists need to be comfortable in dealing with these autopsies. The importance of an adequate fetal examination has been emphasized in a recent policy on the subject by the American Board of Pathology http://www.abpath.org/FetalAutopsyPoli'cy.pdf. This second review paper covers the approach to hydrops fetalis. The approach to the nonanomalous and anomalous fetus was covered in the first part of this series.

show abstract

“…In a rat model of LCMV, pups introduced to the virus early in gestation (days 1-10) had more frequent and severe neuropathologies compared to pups exposed later in gestation [10]. In part, this effect has been attributed to the teratogenic impact of infection during early fetal development—most evident after early transplacental rubella and varicella infections [11, 12]. However, maternal-fetal immune interactions evolve throughout pregnancy [13], possibly changing the placental response to viral pathogens as pregnancy progresses.…”

Section: Introductionmentioning

confidence: 99%

Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta

Enninga

Theiler

2019

Journal of Immunology Research

View full text Add to dashboard Cite

Lymphocytic choriomeningitis virus (LCMV) is a rodent disease that can be transmitted to humans. A majority of persons infected with LCMV have only minor symptoms; however, it can cross the placental barrier during pregnancy and cause congenital defects in the fetus. Some viral infections early in gestation are hypothesized to lead to worse outcomes compared to those acquired during late gestation; however, LCMV has not been studied in this context. In the present study, differences in immunomodulation between the first- and third-trimester placental explants infected with LCMV were measured. LCMV replication was observed in the first-trimester chorionic villi, but not in term. The term placenta exhibited a robust innate immune response to infection by LCMV, marked by induction of ifn-α, il-6, and tnf-α gene expression which was not seen in the first-trimester explants. Cytokine secretion was also only seen in term explants. The results indicate that the first-trimester and term placentas differ in their permissiveness for LCMV infection, inversely correlating with the innate antiviral responses. This has implications for developing effective mechanisms that protect the fetus from infection based on stage of development.

show abstract

Second trimester fetal death caused by varicella‐zoster virus infection

Cited by 5 publications

References 17 publications

How Does Imaging of Congenital Zika Compare with Imaging of Other TORCH Infections?

How Does Imaging of Congenital Zika Compare with Imaging of Other TORCH Infections?

Pathology of the Stillborn Infant for the General Pathologist

Lymphocytic Choriomeningitis Virus Infection Demonstrates Higher Replicative Capacity and Decreased Antiviral Response in the First-Trimester Placenta

Contact Info

Product

Resources

About