Second trimester fetal nasal bone length in a low‐risk Turkish population

Yanık, Filiz; Eroğlu, Derya; Başer, Eralp; Dursun, Polat; Karakaya, Burcu Kisa

doi:10.1002/pd.2811

Cited by 9 publications

(17 citation statements)

References 22 publications

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“…When the 5th, 50th and 95th centile of NBLs were plotted and compared with other ethnic data (Figure ), it was seen that the Indian NBLs were shorter than most other ethnicities. The 5th centile and the median NBLs of the Indian population correlated with the Korean NBLs (Jung et al .…”

Section: Distribution Of Nasal Bone Lengths In Millimetres and The Bpmentioning

confidence: 95%

Nasal bone length: the long and short of it. Evaluation of the reference values for the fetal nasal bone length at 16 to 25 weeks of gestational age in an Indian population

Sharma

Tayal

et al. 2013

Prenatal Diagnosis

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Section: Distribution Of Nasal Bone Lengths In Millimetres and The Bpmentioning

confidence: 95%

Nasal bone length: the long and short of it. Evaluation of the reference values for the fetal nasal bone length at 16 to 25 weeks of gestational age in an Indian population

Sharma

Tayal

et al. 2013

Prenatal Diagnosis

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“…15 Yanik et al have reported nasal bone lengths of Turkish gender as 3.8mm in 16 week old fetuses and 6.35mm in 23 week old fetuses. 16 Many researchers have reported in the literature that nasal bone length increased in parallel with the gestational age. [15][16][17] In present study, nasal bone length was detected as 8.30±2.20mm in male fetuses and as 7.97±1.53mm in female fetuses.…”

Section: Discussionmentioning

confidence: 99%

“…16 Many researchers have reported in the literature that nasal bone length increased in parallel with the gestational age. [15][16][17] In present study, nasal bone length was detected as 8.30±2.20mm in male fetuses and as 7.97±1.53mm in female fetuses. The difference between the literature and our study was originated from gestational age difference.…”

Section: Discussionmentioning

confidence: 99%

An assessment of nasal and orbital parameters in human fetuses

et al. 2017

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Background: Nasal bone aplasia and hypoplasia have been reported on fetuses with aneuploidy. Trisomy 21 is one of the most common chromosomal abnormality detected in new-borns. The purpose of our study is to obtain data of some face parameters in Turkish fetal population and to contribute creation of reference ranges that may be used for prenatal diagnosis.Methods: This study was performed in 66 spontaneously aborted fetuses (47 second trimester and 19 third trimester) (28 male and 38 female) with no detectable external pathology or anomalies. Measurements were designed as nasal bone length (NBL), nose length (NL), nose width (NW), nostril width (NsW), intraocular distance (IOD), innercanthal distance (ICD), outercanthal distance (OCD), orbital diameter (OD), biparietal diameter (BPD).Results: In comparison between genders, ICD and BPD averages were found significantly higher in male fetuses than female fetuses (P<0.05). There was not any statistically significant difference between averages of the values on the right and left. The difference between second and the third trimester was significant in terms of all parameters (P<0.05). A strong correlation was detected between gestational age and our parameters.Conclusions: Present study has contributed to create reference ranges of Turkish community. When importance of early diagnosis is considered, we believe that this data will be useful for clinicians.

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“…Previous studies investigating the impact of [22] , Afro-American [23] , Chinese [11,12] , Korean [13] , Iranian [14] , Turkish [15,16] , Indian [17] , Japanese [18] , South American [19] , and Australian [20] ( table 2 ). How- ever, ethnicity-related variations in NBL during gestation are likely to have an impact on the efficacy of NBL-based screening for trisomy 21.…”

Section: Discussionmentioning

confidence: 99%

“…Chen et al [11] detected shorter fetal NBs in the Chinese population. Several studies have since shown the impact of race and ethnicity on the nasal bone length (NBL) in second-trimester fetuses: Chinese [11,12] , Korean [13] , Iranian [14] , Turkish [15,16] , Indian [17] , Japanese [18] , Brazilian [19] , and Australian [20] . However, no data have been published about the reference range of NBL of normal fetuses in a large AfroCaribbean population.…”

Section: Introductionmentioning

confidence: 99%

Normal Range of Fetal Nasal Bone Length during the Second Trimester in an Afro-Caribbean Population and Likelihood Ratio for Trisomy 21 of Absent or Hypoplastic Nasal Bone

Gautier

Gueneret²,

Plavonil³

et al. 2016

Fetal Diagn Ther

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Objective: To establish the normal reference range of fetal nasal bone length (NBL) during the second trimester in an Afro-Caribbean population and the likelihood ratio (LR) for fetal trisomy 21. Methods: Prenatal records of euploid, non-malformed singleton fetuses who underwent second-trimester ultrasonographic scans at 20-24 weeks of gestation were retrospectively analyzed for NBL and gestational age (GA). Only Afro-Caribbean couples were selected. The relationship between fetal NBL and GA was determined. The data of all fetuses with Down syndrome were provided by the French West Indies Register of Congenital Malformations (REMALAN). Results: There was a significant linear association between fetal NBL and GA (R² = 0. 354). The 50th percentile for NBL increased from 5.0 to 7.0 mm from week 20 to 24 of gestation. The nasal bone (NB) was absent or hypoplastic in 8.6% of the euploid fetuses and in 69.2% of the trisomy 21 fetuses. The LR for trisomy 21 of absent or hypoplastic NB in an Afro-Caribbean population was 8.02, but only 2.32 when this sign was isolated. Conclusion: The reference range for fetal NBL at 20-24 weeks of gestation in an Afro-Caribbean population and the LR for trisomy 21 of absent or hypoplastic NB differed from the other populations.

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Second trimester fetal nasal bone length in a low‐risk Turkish population

Abstract: The study provides normal ranges of NBL between 16 and 23 weeks of pregnancy in a low-risk Turkish population. Future studies with larger sample sizes including pregnancies carrying high risk for aneuploidy are needed to define cut-off values for NBL.

Cited by 9 publications

References 22 publications

Nasal bone length: the long and short of it. Evaluation of the reference values for the fetal nasal bone length at 16 to 25 weeks of gestational age in an Indian population

Nasal bone length: the long and short of it. Evaluation of the reference values for the fetal nasal bone length at 16 to 25 weeks of gestational age in an Indian population

An assessment of nasal and orbital parameters in human fetuses

Normal Range of Fetal Nasal Bone Length during the Second Trimester in an Afro-Caribbean Population and Likelihood Ratio for Trisomy 21 of Absent or Hypoplastic Nasal Bone

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