Second-Trimester Maternal Serum Alpha-Fetoprotein and Risk of Adverse Pregnancy Outcome

Krause, Tyra Grove; Christens, Peter; Wohlfahrt, Jan; Lei, Ulrikke; Westergaard, Tine; Nørgaard‐Pedersen, Bent; Melbye, Mads

doi:10.1097/00006250-200102000-00021

Cited by 18 publications

(22 citation statements)

References 27 publications

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“…It is usually investigated during the diagnoses of fetal chromosomal anomalies and neural tube defects in the later stages of pregnancy (13,16). Previous studies have reported a strong association between low MS-AFP (<0.05 MoM) and gestational complications, such as fetal death, spontaneous abortion, anembryonic pregnancy, preterm labor and macrosomia (16)(17)(18)(19)(20)(21). In addition to fetal chromosomal anomalies, high MS-AFP (AFP>2.5 MoM) has been shown to be related to placental pathology, multiple pregnancy and fetal death (13).…”

Section: Discussionmentioning

confidence: 99%

Low VEGF expression in conceptus material and maternal serum AFP and levels as indicators of defective angiogenesis in first-trimester miscarriages

Kutluer¹,

Çiçek²,

Moraloğlu³

et al. 2012

J Turkish German Gynecol Assoc

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Low VEGF expression in conceptus material and maternal serum AFP and β-hCG levels as indicators of defective angiogenesis in first-trimester miscarriages Objective: The aims of this study were to assess the relationship between early miscarriages and vascular endothelial growth factor (VEGF) expression and to determine the serum levels of first-trimester maternal alpha-fetoprotein (AFP) and human chorionic gonadotropin (β-hCG) as markers of angiogenesis and predictors of abortion and intrauterine fetal loss. Material and Methods:The present study was a prospective, singlecenter, randomized controlled clinical trial. Ninety-five women who were 6-10 weeks pregnant between May and June 2010 were included in the study. The subjects were divided into three groups, i.e., incomplete abortion (IA) (n=31), intrauterine death (IU-D) (n=32) and control (elective pregnancy termination) (n=32). Feto-placental materials were compared based on immune staining for VEGF in the pathology laboratory, and maternal serum samples were tested in the hormone laboratory.Results: Serum β-hCG levels in the patient groups were significantly lower than the controls (p=0.001). The serum AFP level was lower than the controls in the IA group while it was higher than the controls in the IU-D (p=0.016). Immunohistochemistry showed that the cytotrophoblast, syncytiotrophoblast and endometrial gland epithelium were weakly stained for VEGF in the patient groups (IA and IU-D) in comparison to the control group (p=0.06, p=0.028, p=0.006). Conclusion:Early pregnancy losses are related to insufficient angiogenesis, and maternal serum AFP and β-hCG can be used as markers of angiogenesis in the first trimester.(J Turkish-German Gynecol Assoc 2012; 13: 111-7) Abstract ÖzetOriginal Investigation 111

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Section: Discussionmentioning

confidence: 99%

Low VEGF expression in conceptus material and maternal serum AFP and levels as indicators of defective angiogenesis in first-trimester miscarriages

Kutluer¹,

Çiçek²,

Moraloğlu³

et al. 2012

J Turkish German Gynecol Assoc

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“…More recently Krause et al also found a significant association with an MSAFP MoM > 2.5 and still birth (p = 0.001). However, when adjusted for low birth weight the association was insignificant [10].…”

Section: Introductionmentioning

confidence: 88%

“…Burton found that amongst women who had elevated MSAFP values > 2.5 MoM, 15% delivered small for gestational age infants compared to only 7.2% among women with normal MSAFP values [8]. More recent studies have also confirmed these findings [5,[9][10][11]. However, studies by Smith and McPhearson showed no significant increase in IUGR with an elevated AFP [4,12].…”

Section: Introductionmentioning

confidence: 95%

The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome

Allen¹,

Marleen²,

Velauthar³

et al. 2013

OJOG

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“…In a pregnancy, there can be multiple gestations, as in the case of twins or triplets, occurs as the result of the female egg being penetrated by the male spermatozoon in a process of fertilization, or more commonly known as "conception" [16].…”

Section: Introduction and Literature Reviewmentioning

confidence: 99%

“…Since the triple maternal serum test is only a screening tool, an abnormal test result is not necessarily indicative of a birth defect. Accurate gestational dating lowers the false-positive and false-negative rates associated with this screening test [20] [16].…”

Section: Introduction and Literature Reviewmentioning

confidence: 99%

Maternal Serum Triple Screening Test and Pregnancy Outcome in Elderly Sudanese Pregnant Ladies in Khartoum State-Sudan

Gurashi¹,

Fadl-Elmula²

2017

AJLM

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Abstract:The possibility to deliver infants with congenital defects or diseases is thought to be associated with increased in maternal age. This fact is well established and documented in previous studies done in the United States of America. Infants with birth defects is not the only disastrous outcome, pregnancy and delivery complications, abortion, stillbirth are also known consequences. The aim of this study, to detect a possible association between increased maternal age, and Triple Screening Test results. And compare the findings of the Triple Screening Test results with abnormal pregnancy outcome among Sudanese pregnant ladies. Study performed in ninety-one pregnant ladies accepted to participate. Participants were assigned to two groups; study group including 69 (75.8%) women equal to and above 35 years and control group including 22 (24.2%) women less than 30 years. Structured questionnaire, clinical examinations including ultra-sound for the determination of gestational age were also performed. Blood samples were collected from all participants during the 14 th to 20 th week of gestational age. Sera were separated and used for the determination of human chorionic gonadotropin, alpha fetoprotein, and free estriol concentrations using standardized quantitative methods (ELISA) collectively known as the Triple Screening Test. In the study group, participants delivered 57 (82.6%) normal healthy infants. Twelve ladies (17.4%) delivered infants with adverse dimorphic features. The defects varied; four (5.8%) had stillbirth, four (5.8%) had abortion at the second trimester, three (4.3%) had premature delivery, and one (1.4%) had intrauterine death. And matching control group, none of the participants (0%) give birth to an infant with congenital defect. Highly significant positive correlation was detected between increase in maternal age and abnormal pregnancy outcome. The Triple Screening Test against the pregnancy outcome in study group, showed statistically significant differences between levels of β-HCG, AFP, and Free estriol and pregnancy outcomes with Pvalues of 0.000, 0.5240, and 0.000 were obtained using Pearson Chi-squire test of significance, respectively. Study conclude that abnormal pregnancy outcome is strongly associated with increase in maternal age. Also there were strongly association between the Triple Screening Test and abnormal pregnancy outcome.

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Second-Trimester Maternal Serum Alpha-Fetoprotein and Risk of Adverse Pregnancy Outcome

Cited by 18 publications

References 27 publications

Low VEGF expression in conceptus material and maternal serum AFP and levels as indicators of defective angiogenesis in first-trimester miscarriages

Low VEGF expression in conceptus material and maternal serum AFP and levels as indicators of defective angiogenesis in first-trimester miscarriages

The relationship between second trimester alpha fetoprotein levels and adverse pregnancy outcome

Maternal Serum Triple Screening Test and Pregnancy Outcome in Elderly Sudanese Pregnant Ladies in Khartoum State-Sudan

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