Second-trimester plasma mannose-binding lectin levels and risk of preterm birth

Wang, Liang-Kai; Huang, Ming-Chao; Liu, Chang-Ching; Chen, Chie‐Pein

doi:10.1080/14767058.2016.1182978

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…They found no significant differences in the levels of MBL between term and preterm patients during second trimester. However, among mothers with term pregnancies, the MBL plasma levels increased significantly from the second trimester to delivery, whereas in mothers who delivered preterm the MBL levels did not change . In contrast, Thevenon et al reported relatively constant concentrations of MBL throughout pregnancy.…”

Section: Discussionmentioning

confidence: 85%

“…However, others found no differences in the functional activity of MBL‐MASP in preeclamptic patients vs controls . Several studies investigated the role of MBL polymorphism and serum levels in preterm birth . van de Geijn et al found an association between the maternal high MBL genotype group A and premature birth, suggesting that during pregnancy MBL‐associated inflammation caused by higher MBL activity may contribute to earlier delivery.…”

Section: Introductionmentioning

confidence: 78%

“…However, among mothers with term pregnancies, the MBL plasma levels increased significantly from the second trimester to delivery, whereas in mothers who delivered preterm the MBL levels did not change. 25 In contrast, Thevenon et al 36 in the literature as to the role of MBL in preterm labour and other pregnancy pathologies. Future studies are likely to explore the interaction of the maternal immune system with its microbiome, and how this can lead to preterm labour, particularly in the presence of underlying abnormalities of the native or acquired immune system.…”

Section: Discussionmentioning

confidence: 99%

“…van de Geijn et al found an association between the maternal high MBL genotype group A and premature birth, suggesting that during pregnancy MBL‐associated inflammation caused by higher MBL activity may contribute to earlier delivery. In contrast, Wang et al did not show any correlation between MBL concentrations and the length of gestation. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth in a cohort of women with threatened preterm birth who had clinical (preterm contractions) and subclinical (short cervix) risk factors of preterm delivery.…”

Section: Introductionmentioning

confidence: 99%

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Low maternal serum concentrations of mannose‐binding lectin are associated with the risk of shorter duration of pregnancy and lower birthweight

et al. 2018

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Chronic inflammation has been implicated as the underlying mechanism responsible for the pathophysiology of preterm labour. Mannose-binding lectin (MBL) plays a central role in the innate immune response and is thus an important component of the first line of defense. The aim of this study was to investigate whether serum concentrations of MBL correlated with the incidence of preterm birth and low birthweight in a cohort of women with signs of threatened preterm birth. A cohort of 60 patients who presented with regular contractions and/or short cervix (group A) between 24 and 32 weeks of gestation and 20 healthy controls (group B) who had no pregnancy complications and delivered at term were recruited into a prospective study. The following outcomes were recorded: presence of preterm labour and birthweight in all patients. MBL and high sensitivity C-reactive protein levels were measured in all serum samples. The serum concentrations of MBL were significantly reduced in patients with threatened preterm labour (Group A), compared to the control Group B. Furthermore, infants born to Group A mothers with MBL deficiency (n = 13, MBL ≤100 ng/mL) had significantly lower birthweights, compared to those born to Group A women with normal MBL serum concentrations (P < .0001). Our small cohort study demonstrated a strong association between MBL deficiency and preterm delivery, and associated low birthweight. MBL deficiency could thus be considered an important risk factor for preterm birth.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Low maternal serum concentrations of mannose‐binding lectin are associated with the risk of shorter duration of pregnancy and lower birthweight

et al. 2018

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“…In addition, no association between low p-MBL level and preterm birth was found in the present and the previous studies in RPL patients [1,174]. In contrast, the findings from studies in women with no reproductive complications were contradictory regarding which MBL2 genotypes conferred an increased risk of preterm birth [178,184,293]. In contrast to our findings, Kruse et al ( 2002) found a higher miscarriage rate and a 287g lower mean birth weight in neonates born at term by RPL patients with a low p-MBL level (<100 µg/l) compared to patients with higher p-MBL levels [174].…”

Section: Discussioncontrasting

confidence: 89%

Recurrent Pregnancy Loss: immunological risk factors and immunomodulatory treatments

Nørgaard-Pedersen

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Maternal genetic risk factors for spontaneous preterm birth: A systematic review and meta‐analysis

Mladenić,

Barišić,

Pereza

et al. 2024

Intl J Gynecology & Obste

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BackgroundDespite various genomic approaches used in prior studies investigating the association of maternal genetic variability with spontaneous preterm birth (sPTB), results show inconsistency and contradictions.ObjectivesTo conduct a systematic review of studies analyzing the association between maternal genetic variants and sPTB, evaluate retrieved studies based on selection criteria, classify studies into hypothesis‐based and hypothesis‐free, and perform a meta‐analysis to identify the strongest associations.Search strategyPubMed, Scopus, and reference lists were searched until October 2024.Selection criteriaEnglish‐language, case–control, cross‐sectional, and prospective cohort studies examining the association between maternal genetic variations and sPTB were included.Data collection and analysisData on authors, publication year, ethnicity, genes/variants, P values, study type, sample size, inclusion criteria, and methods were collected. The association strength was estimated using odds ratios with 95% confidence intervals.ResultsEighty‐one studies met eligibility criteria: 73 utilized a hypothesis‐based and 14 a hypothesis‐free approach. Thirty‐five studies qualified for a meta‐analysis, revealing a significant association in tumor necrosis factor α (rs1800629) gene for alleles and additive and recessive genetic models (P ≤ 0.05). From the hypothesis‐free approach, 13 genes reached global significance in association with sPTB (P < 5 × 10−8).ConclusionsNo single gene or variant was consistently associated with sPTB risk among studies. Hypothesis‐based analyses highlighted tumor necrosis factor α (rs1800629) as a modest signal, while hypothesis‐free approaches identified 13 genes with genome‐wide significance, pointing to new research directions in understanding sPTB genetics.

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Second-trimester plasma mannose-binding lectin levels and risk of preterm birth

Abstract: Genotypes associated with low levels of plasma MBL during pregnancy did not increase the risk of preterm births. A low second-trimester plasma MBL level is therefore not a predictor for the development of preterm birth.

Cited by 6 publications

References 34 publications

Low maternal serum concentrations of mannose‐binding lectin are associated with the risk of shorter duration of pregnancy and lower birthweight

Low maternal serum concentrations of mannose‐binding lectin are associated with the risk of shorter duration of pregnancy and lower birthweight

Recurrent Pregnancy Loss: immunological risk factors and immunomodulatory treatments

Maternal genetic risk factors for spontaneous preterm birth: A systematic review and meta‐analysis

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