“…4 Osmotic dilators or misoprostol, or a combination, are the most common methods for cervical preparation utilised in the USA. 4,5 Osmotic dilators, Dilapan-S and Laminaria, are cervical dilators that expand to a maximum diameter over 4-6 and 18-24 hours, respectively, to soften and dilate https://clinicaltrials.gov/ct2/show/NCT01862991 the cervix prior to D&E. 6,7 The use of osmotic dilators requires the woman to have an outpatient procedure in the day(s) prior to the day of the D&E. 4 Prior to D&E, misoprostol aids in cervical softening and decreases the force required for mechanical cervical dilation. 8 Studies of mifepristone for medical abortion in the second trimester, showing a 40-50% reduction in abortion times, 9 influenced research on cervical preparation for second trimester surgical abortion and increased the use of mifepristone for cervical preparation prior to D&E. [10][11][12][13][14][15] Mifepristone as an adjunct to osmotic dilators decreases the number of osmotic dilators needed after 19 weeks.…”