Second trimester uterocervical angle and spontaneous preterm birth in twins

Lynch, Tara A.; Szlachetka, Kam; Seligman, Neil S.

doi:10.1080/14767058.2019.1569615

Cited by 14 publications

(16 citation statements)

References 13 publications

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“…Eleven studies all conducted on the second trimester UCA as well as its association with sPTB were included in this study [12-14, 17-24], with a total of 5,061 patients (4,511 Singleton and 550 twin). Of these studies, 6 were prospective [12, 14, 17, 20, 23, 24] and 5 were retrospective studies [13, 18, 19, 21, 22]. Except one study [23], all UCA measurements were performed transvaginally in other studies.…”

Section: Resultsmentioning

confidence: 99%

“…Except one study [23], all UCA measurements were performed transvaginally in other studies. Notable, all these studies were published between 2016 and 2020, and 3 studies were conducted in the USA [19, 21, 22], 3 in Spain [13, 18, 20], one in Turkey [17], one in China [23], one in Chile [14], one in Thailand [12], and one in India [24]. The characteristics of these eleven included articles with more details are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

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The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis

et al. 2021

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The alteration of the uterocervical angle (UCA) has been proposed to play an important role in spontaneous preterm birth (sPTB). The aim of this systematic review and meta-analysis was to evaluate the evidence on the UCA predictive role in sPTB. In this study, PubMed, Web of Science, Scopus, and Google scholar were systematically searched from inception up to June 2020. Inter-study heterogeneity was also assessed using Cochrane’s Q test and the I2 statistic. Afterward, the random-effects model was used to pool the weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Eleven articles that reported second-trimester UCA of 5,061 pregnancies were included in this study. Our meta-analysis results indicate that a wider UCA significantly increases the risk of sPTB in following cases: all pregnancies (WMD = 15.25, 95% CI: 11.78–18.72, p < 0.001; I2 = 75.9%, p < 0.001), singleton (WMD = 14.43, 95% CI: 8.79–20.06, p < 0.001; I2 = 82.4%, p < 0.001), and twin pregnancies (WMD = 15.14, 95% CI: 13.42–16.87, p < 0.001; I2 = 0.0%, p = 0.464). A wider ultrasound-measured UCA in the second trimester seems to be associated with the increased risk of sPTB in both singleton and twin pregnancies, which reinforces the clinical evidence that UCA has the potential to be used as a predictive marker of sPTB.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis

et al. 2021

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“…Likewise, Lynch and colleagues [19] aimed to determine if there is an association between UCA and sPTB < 37 weeks. Retrospective cohort study from 2014 to 2017 of pregnancies with cervical length (CL) screening between 15 and 24 weeks was conducted.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Uterocervical Angle and Prediction of Spontaneous Preterm Birth

Makled

Abuelghar

Shabaan

et al. 2021

Evidence Based Women's Health Journal

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Aim: This study aimed to determine whether a novel ultrasonographic marker, uterocervical angle, correlates with risk of spontaneous preterm birth. Materials and Methods: In the present prospective, cohort, study, we included 197 singleton pregnant women at Ain shams university maternity hospital (outpatient obstetrics clinics and emergency department. The mean age of the included women was 27.2 ± 4.8 years while the mean party was 2.2 ±1.3. The mean BMI was 33.4 ± 2.6Kg/m2. Results: In the present study, we found that there were statistically significant differences between both groups in terms of history of preterm labor (p <0.001) and tobacco smoking (p =0.008). Smokers and women with history of PTB had higher risk of PTB. In our report, there were statistically significant differences between both groups in terms of neonatal mortality. With regard to the primary outcome of the present study, we found that there was statistically significant difference between women with spontaneous preterm labor and women with term deliveries regarding UCA (p =0.015). Mean UCA in the second trimester was wider in the preterm group compared with the control group. The UCA was a significant discriminator of preterm labor. At cut-off value of ≥ 105, the GP37 yielded a sensitivity of 86.7% and specificity of 89% for the discrimination between preterm and term deliveries. Conclusion:Wider UCA in the second trimester is related to spontaneous PTB. UCA measurement is a reproducible technique. UCA appears to increase from the first to the second trimester.

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“…7 Unfortunately, no UCA cut-off exists that implies a high risk of sPTB with a low false-positive rate. A wide UCA correlates with sPTB; [13][14][15][16][17][18] however, per se it does not provide much information on the risk of an individual pregnancy developing this complication. The UCA and CL combination might provide a higher detection rate for sPTB compared with CL alone.…”

Section: Discussionmentioning

confidence: 99%

“…Many factors underlying the risk of sPTB in a pregnant woman include maternal history, 6 obstetric ultrasound findings—such as a short cervix 7,8 , vaginal microbiome 9,10 and genetics 11,12 . Recent data suggest that the anterior uterocervical angle (UCA)—defined as the angle between the lower anterior uterine wall and the cervix—may predict sPTB 13‐16 . Some studies even suggest that the UCA could better predict sPTB than cervical length (CL) 17,18 …”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of the uterocervical angle as a predictor of spontaneous preterm birth

Farrás

Higueras

Calero

et al. 2020

Acta Obstet Gynecol Scand

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Introduction: The uterocervical angle has been proposed as an ultrasound marker to predict spontaneous preterm birth; however, the studies that provided this evidence were retrospective and their results heterogeneous. This study aimed to assess the ability of the uterocervical angle to predict spontaneous preterm birth before 34 and 37 weeks of gestation. How to cite this article: Farràs Llobet A, Higueras T, Calero IZ, et al. Prospective evaluation of the uterocervical angle as a predictor of spontaneous preterm birth.

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Second trimester uterocervical angle and spontaneous preterm birth in twins

Cited by 14 publications

References 13 publications

The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis

The Novel Ultrasonographic Marker of Uterocervical Angle for Prediction of Spontaneous Preterm Birth in Singleton and Twin Pregnancies: A Systematic Review and Meta-Analysis

Relationship between Uterocervical Angle and Prediction of Spontaneous Preterm Birth

Prospective evaluation of the uterocervical angle as a predictor of spontaneous preterm birth

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