Let ψ:(M, g) → (N, h) be a map between Riemannian manifolds (M, g) and (N, h). We introduce the notion of the F-bienergy functional$$\begin{array}{}
\displaystyle
E_{F,2}(\psi)=\int\limits_{M}F\left(\frac{|\tau(\psi)|^{2}}{2}\right)\text{d}V_{g},
\end{array}$$where F : [0, ∞) → [0, ∞) be C3 function such that F′ > 0 on (0, ∞), τ(ψ) is the tension field of ψ. Critical points of τF,2 are called F-biharmonic maps. In this paper, we prove a nonexistence result for F-biharmonic maps from a complete non-compact Riemannian manifold of dimension m = dimM ≥ 3 with infinite volume that admit an Euclidean type Sobolev inequality into general Riemannian manifold whose sectional curvature is bounded from above. Under these geometric assumptions we show that if the Lp-norm (p > 1) of the tension field is bounded and the m-energy of the maps is sufficiently small, then every F-biharmonic map must be harmonic. We also get a Liouville-type result under proper integral conditions which generalize the result of [Branding V., Luo Y., A nonexistence theorem for proper biharmonic maps into general Riemannian manifolds, 2018, arXiv: 1806.11441v2].