Secondary (AA-type) amyloidosis in patients with polymyalgia rheumatica

Escribá, A.; Morales, Enrique; Albizúa, Enriqueta; Herrero, Juan Carlos; Ortuño, T; Parrilla, Agustín Carreño; Domínguez‐Gil, Beatriz; Praga, Manuel

doi:10.1016/s0272-6386(00)70312-x

Cited by 22 publications

(17 citation statements)

References 24 publications

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“…10 Malignant neoplasms have also been implicated and include Hodgkin's disease; renal cell carcinoma; carcinoma of the gut, lung, and urogenital tract; basal cell carcinoma; and hairy cell leukemia.…”

Section: Discussionmentioning

confidence: 99%

Secondary amyloidosis as a life‐ending event in multifocal motor neuropathy

Beydoun¹,

Rison²,

Commins³

2001

Muscle and Nerve

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Multifocal motor neuropathy (MMN) is a disorder of peripheral nerve often associated with a high monosialoganglioside (GM1) antibody and multifocal conduction block. It has a chronic, indolent course with involvement of predominantly peripheral motor nerves, usually in an asymmetric fashion. There have been few reported cases of progression to frank quadriplegia. Secondary amyloidosis refers to the deposition of amyloid in various tissues due to an underlying chronic inflammatory state. We report the first case, to our knowledge, of a patient with MMN associated with high titer of GM1 antibody who developed acute paraplegia with both cranial nerve and worsening sensory involvement associated with multiorgan compromise due to a secondary amyloidosis involving the myocardium.

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Section: Discussionmentioning

confidence: 99%

Secondary amyloidosis as a life‐ending event in multifocal motor neuropathy

Beydoun¹,

Rison²,

Commins³

2001

Muscle and Nerve

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show abstract

“…In our case series, many patients were treated with high-dose steroids. Although 1 patient treated with low-dose prednisone showed stabilization of renal function over 2 years of followup 12 , renal recovery was not achieved in any of these cases using prednisone alone, and most patients died of progressive renal failure within months to 2 years 5,6,11 . In familial Mediterranean fever, a condition commonly associated with AA amyloidosis, the incidence of amyloidosis is lower in those patients treated with colchicine, and there have been reports of improvement in proteinuria 14 and even reversal of nephrotic syndrome 15,16 .…”

Section: To the Editormentioning

confidence: 94%

“…She did have evidence of bronchiectasis on CT scan, a condition that has also been associated with AA amyloidosis, but she had been relatively asymptomatic. Two of the previous case reports also described patients with well controlled GCA/PMR who developed AA amyloidosis 6,12 . This suggests either subclinical disease in seemingly well controlled GCA/PMR, or an alternative mechanism for AA amyloid deposition.…”

Section: To the Editormentioning

confidence: 95%

“…AA amyloidosis is found in several rheumatological conditions, most notably rheumatoid arthritis (RA) 4 . GCA and/or PMR have rarely been associated with amyloid 5,6,7,8,9,10,11,12 . Among patients with RA, AA amyloidosis has been most commonly identified in more severe and poorly controlled disease, and it is theorized that it is the chronically uncontrolled inflammatory medium that results in elevated levels of the SAA protein and subsequent accumulation as amyloid 13 .…”

Section: To the Editormentioning

confidence: 99%

“…Thus it is possible that this secondary amyloidosis is associated, as in RA, with ongoing inflammation 5,6,7,10,11 . Interestingly, our patient had quiescent disease with normalization of the ESR in the intervening period.…”

Section: To the Editormentioning

confidence: 99%

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