Secondary acute myeloid leukemia with a t(1;11)(q23;p15) in an adolescent treated for testicular sarcoma

t(1;11)(q24;p15) NUP98/PRRX1

“…5 patients with confirmed NUP98 rearrangement (4 males and 1 female aged 42 to 74 years, median 51 years) (Hatano et al, 2000Kobzev et al, 2004Bai et al, 2006;Zhang et al, 2007) and an 18 years old male without molecular studies (Soares et al, 2006). NUP98 rearrangement was also detected in a 36 years old male (unpublished data).…”

“…In 1 AML-M2 patient, complete remission of leukemia was achieved, but the NHL relapsed and an advanced gastric carcinoma was found and the patient died shortly afterwards (Hatano et al, 2000) and the other patient with AML-M2 died 5 months after leukemia onset (Soares et al, 2006). The 2 other AML patients died shortly after the onset of leukemia (Kobzev et al, 2004;Zhang et al, 2007) as well as the patient with CML in transformation (Kobzev et al, 2004).…”

“…Acute myeloid leukemia in 4: 2 patients with AML with maturation (AML-M2), in 1 of them that developed 3 years after the start of chemotherapy (MACOP-B) for stage III non-Hodgkin lymphoma (NHL)(immunoblast type) (Nakamura et al, 1999;Hatano et al, 2000) and in the other it was diagnosed 3 years after chemotherapy (ifosfamide, adriamycin, cytoxan, etopside) and radiotherapy for sarcoma of the testis (Soares et al, 2006). 1 patient was diagnosed with AML with minimal maturation (AML-M1) who received chemotherapy (adriamycin, cytoxan, 5-FU) and bone marrow transplantation for breast adenocarcinoma (Kobzev et al, 2004), 1 with myelodysplastic syndrome evolving into acute myelomonocytic leukemia (M4) that developed after chemotherapy (doxorubicin, ifosfamide) and radiotherapy for liposarcoma with the latency period from chemotherapy to the onset of MDS (treated with azacytidine) 30 months and of AML 38 months (Zhang et al, 2007).…”