“…However, osteoporosis is not simply a disease of bone loss and recent studies have demonstrated that bone tissue composition is fundamentally altered at the tissue level (Gadeleta et al, 2000;Harris et al, 2000;Zioupos and Aspden, 2000;Efstathiadou et al, 2001;Ciarelli et al, 2003;Mansell and Bailey, 2003;McCreadie et al, 2006;McNamara et al, 2006;Zhu et al, 2008). In particular, changes in bone tissue mineral occur, which are anatomically distinct, do not occur ubiquitously throughout the proximal femur, and may be associated with alterations in the cell mechanical environment (Riggs et al, 2002;McNamara et al, 2005McNamara et al, , 2006Brennan et al, 2011aBrennan et al, ,b, 2012bBrennan et al, , 2014aVaughan et al, 2015;Verbruggen et al, 2015Verbruggen et al, , 2016O'Sullivan et al, 2019;Parle et al, 2020).…”