2019
DOI: 10.1007/s00198-019-05239-5
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Secondary alterations in bone mineralisation and trabecular thickening occur after long-term estrogen deficiency in ovariectomised rat tibiae, which do not coincide with initial rapid bone loss

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Cited by 13 publications
(16 citation statements)
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“…However, osteoporosis is not simply a disease of bone loss and recent studies have demonstrated that bone tissue composition is fundamentally altered at the tissue level (Gadeleta et al, 2000;Harris et al, 2000;Zioupos and Aspden, 2000;Efstathiadou et al, 2001;Ciarelli et al, 2003;Mansell and Bailey, 2003;McCreadie et al, 2006;McNamara et al, 2006;Zhu et al, 2008). In particular, changes in bone tissue mineral occur, which are anatomically distinct, do not occur ubiquitously throughout the proximal femur, and may be associated with alterations in the cell mechanical environment (Riggs et al, 2002;McNamara et al, 2005McNamara et al, , 2006Brennan et al, 2011aBrennan et al, ,b, 2012bBrennan et al, , 2014aVaughan et al, 2015;Verbruggen et al, 2015Verbruggen et al, , 2016O'Sullivan et al, 2019;Parle et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…However, osteoporosis is not simply a disease of bone loss and recent studies have demonstrated that bone tissue composition is fundamentally altered at the tissue level (Gadeleta et al, 2000;Harris et al, 2000;Zioupos and Aspden, 2000;Efstathiadou et al, 2001;Ciarelli et al, 2003;Mansell and Bailey, 2003;McCreadie et al, 2006;McNamara et al, 2006;Zhu et al, 2008). In particular, changes in bone tissue mineral occur, which are anatomically distinct, do not occur ubiquitously throughout the proximal femur, and may be associated with alterations in the cell mechanical environment (Riggs et al, 2002;McNamara et al, 2005McNamara et al, , 2006Brennan et al, 2011aBrennan et al, ,b, 2012bBrennan et al, , 2014aVaughan et al, 2015;Verbruggen et al, 2015Verbruggen et al, , 2016O'Sullivan et al, 2019;Parle et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…All values were expressed as a percentage of the absolute value of 1 minus OVX group / control group. O'Sullivan LM et al [4] found that bone mass lost rapidly after estrogen de ciency, and then reached the plateau stage, and then returned to a more balanced remodeling process. The homeostasis of bone reconstruction may be due to the compensatory thickening of bone trabecula after the 14 weeks of estrogen de ciency.…”
Section: Dicussionmentioning
confidence: 99%
“…In addition to BMD, changes in bone microstructure and bone strength should also be considered when predicting the risk of fragility fracture. Micro-computed tomography(CT) can clearly describe the threedimensional distribution and structural characteristics of bone, and accurately measure and monitor the changes of bone volume and bone microstructure [4][5][6]. Serum bone turnover markers (BTMS) can timely re ect the metabolic level of bone formation and bone resorption [7,8], which is helpful to identify the high risk of fragility fracture.…”
Section: Introductionmentioning
confidence: 99%
“…It makes the stiffness of the matrix surrounding bone cells a potential major factor for driving bone homeostasis in post-menopausal osteoporosis. In in vivo models of postmenopausal osteoporosis it has also been shown as well that secondary mineralisation occured at a late stage which might make the bone less compliant and more brittle, and explain the fragility of bone [46]. In addition the variability of phenotype between individual shown a limitation in predicting overall the outcome of osteoporosis when the trabecula thickness is thinner before the diseases is installed [47].…”
Section: Osteoporosismentioning
confidence: 99%