Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency

Zhou, Qianhui; Chen, Ping; Peng, Hong; Ouyang, Ruoyun; Li, Daiqiang

doi:10.4103/0366-6999.205860

Cited by 2 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our patient also had 2 episodes of bacterial meningitis which is not common according to previous studies [4]. In a study by Zhou et al [12], their patient had secondary amenorrhea like our Gastrointestinal symptoms are common in CVID [10,13], although our patient did not complain of them. However, her weight loss can be related to her insidious malabsorption.…”

Section: Discussionsupporting

confidence: 55%

A Young Woman with Common Variable Immunodeficiency: The Role of Thorough Medical History and Physical Examination in Accurate Diagnosis

Khodadadi,

Khodashahi

2024

Case Reports in Medicine

View full text Add to dashboard Cite

Common variable immunodeficiency (CVID) is a rare immunodeficiency syndrome which presents with wide manifestations leading to delayed diagnosis. A 34-year-old woman presented to our hospital complaining of dyspnea and productive cough. Lung CT scan revealed loculated right-sided pleural effusion with bronchiectasis and consolidation in right lower lobes. After taking medical history and physical examination, we suspected CVID and ordered serum immunoglobulin levels. The laboratory results were in line with CVID diagnosis and showed decreased levels of IgG, IgM, and IgA. The patient was started on intravenous immune globulin (IVIG) therapy every month. After 3-month follow-up, the patient reported no problem and felt better.

show abstract

Section: Discussionsupporting

confidence: 55%

A Young Woman with Common Variable Immunodeficiency: The Role of Thorough Medical History and Physical Examination in Accurate Diagnosis

Khodadadi,

Khodashahi

2024

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

“…In particular, growth hormone deficiency (GHD) due to anterior pituitary dysfunction was repeatedly reported (2 patients with mild and 8 patients with severe GHD) (7, 9, 11, 15, 16, 21–24). Other distinct anterior pituitary defects and/or combined with endocrine end-organ dysfunctions were reported (7, 9, 11, 13, 15, 16, 19, 21, 22, 24, 25). The most important characterized reported cases are summarized in Table 1 (6–11, 14, 15, 17–25).…”

Section: Introductionmentioning

confidence: 99%

“…Other distinct anterior pituitary defects and/or combined with endocrine end-organ dysfunctions were reported (7, 9, 11, 13, 15, 16, 19, 21, 22, 24, 25). The most important characterized reported cases are summarized in Table 1 (6–11, 14, 15, 17–25).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Endocrine Disorders Are Prominent Clinical Features in Patients With Primary Antibody Deficiencies

et al. 2019

View full text Add to dashboard Cite

Background: Primary antibody deficiencies (PADs) and anterior pituitary dysfunction are both rare conditions. However, recent studies have remarkably reported the occurrence of anterior pituitary dysfunction in PAD patients. Methods: In this cross-sectional, single-center study we evaluated the prevalence of endocrine disorders in adult PAD patients. Our study focused on common variable immunodeficiency (CVID), immunoglobulin G (IgG) subclass deficiency (IgGSD), and specific anti-polysaccharide antibody deficiency (SPAD). We assessed hormone levels, performed provocative tests and genetic testing in a subset of patients by direct sequencing of the nuclear factor kappa beta subunit 2 ( NFKB2 ) gene and primary immunodeficiency (PID) gene panel testing by whole exome sequencing (WES). Results: Our results demonstrated that one out of 24 IgGSD/SPAD patients had secondary hypothyroidism and three out of 9 men with IgGSD/SPAD had secondary hypogonadism. Premature ovarian failure was observed in four out of 9 women with CVID and primary testicular failure in one out of 15 men with CVID. In two out of 26 CVID patients we found partial adrenal insufficiency (AI) and in one out of 18 patients with IgGSD/SPAD secondary AI was found. Moreover, in one out of 23 patients with CVID and in two out of 17 patients with IgGSD/SPAD severe growth hormone deficiency (GHD) was found, while one patient with IgGSD/SPAD showed mild GHD. Combined endocrine disorders were detected in two women with CVID (either partial secondary AI or autoimmune thyroiditis with primary hypogonadism) and in three men with IgGSD/SPAD (two with either mild GHD or secondary hypothyroidism combined with secondary hypogonadism, and one man with secondary AI and severe GHD). Genetic testing in a subset of patients did not reveal pathogenic variants in NFKB2 or other known PID-associated genes. Conclusion: This is the first study to describe a high prevalence of both anterior pituitary and end-organ endocrine dysfunction in adult PAD patients. As these endocrine disorders may cause considerable health burden, assessment of endocrine axes should be considered in PAD patients.

show abstract

Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency

Cited by 2 publications

References 4 publications

A Young Woman with Common Variable Immunodeficiency: The Role of Thorough Medical History and Physical Examination in Accurate Diagnosis

A Young Woman with Common Variable Immunodeficiency: The Role of Thorough Medical History and Physical Examination in Accurate Diagnosis

Endocrine Disorders Are Prominent Clinical Features in Patients With Primary Antibody Deficiencies

Contact Info

Product

Resources

About