Secondary amyloidosis in Crohn's disease: treatment with tumour necrosis factor inhibitor

Anti-Cytokine Therapy for AA Amyloidosis

“…The number of infections was 3 times higher in AA amyloidosis patients [27]. In addition, it has been reported that anti-TNF treatment is effective for clinical improvement in AA amyloidosis associated with FMF [28] or Crohn's disease [29]. Taking these findings together, treatment of AA amyloidosis with TNF inhibitors is promising, although anti-TNF therapy does not always lead to the better clinical outcomes or normalize serum levels of SAA in AA amyloidosis patients.…”

“…In 2010, Fernandez-Nebro et al reported a multicenter, controlled, dynamic prospective cohort study of 36 patients with AA amyloidosis who were treated with either IFX (29) or ETN (7). As external controls, 35 non-amyloid patients (RA 18, SA 11, PA 5, JIA1, aSD 0, APS 0) treated with TNF drugs were extracted from the Base de Datos de Productos Biológicos de la Sociedad Española de Reumatología registry.…”

Efficacy of scheduled infliximab maintenance therapy on systemic amyloidosis associated with crohnʼs disease

“…Recent studies show the efficacy of infliximab on secondary amyloidosis associated with rheumatic inflammatory diseases. 3,4 However, only a few case reports, including ours, [5][6][7] have shown the therapeutic effects of infliximab on CD-associated amyloidosis. In addition, it is unclear whether scheduled infliximab maintenance therapy can maintain good renal function of such CD patients.…”

“…A previous study suggested that infliximab might act on systemic amyloidosis by improving glomerular inflammation and permeability and blocking serum amyloid A protein production. 8 Notably, Boscá et al 6 showed a decrease in amyloid deposits in the colonic mucosa after 5 years of treatment with infliximab. Many CD patients have suffered from systemic amyloidosis.…”

Nephrotic Syndrome after Infliximab Treatment in a Patient with Ulcerative Colitis

“…Renal amyloidosis or drug toxicity was discussed to explain this situation. The renal biopsy was negative for amyloidosis and several case reports have described the efficacy of anti-TNF-α treatment on amyloid nephropathy complicating long-standing Crohn's disease, a treatment which induces a rapid response in proteinuria and a suppression of the renal disease activity [1][2][3][4][5][6].…”