Secondary Bruch′s membrane defects and scleral staphyloma in toxoplasmosis

Jonas, Jost B.; Panda‐Jonas, Songhomitra

doi:10.1111/aos.13027

Cited by 25 publications

(16 citation statements)

References 11 publications

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“…This notion is in agreement with the clinical observation that non-axially elongated eyes can show scleral staphylomata in regions in which BM developed a defect due to a toxoplasmatic retinochoroidal inflammation. 37 However, we do not exclude the fact that the sclera can also be damaged by inflammation, which could also yield staphyloma. The result of a relatively high rupture pressure of BMCC might have been unexpected because until now, BM has mostly been assigned to a role in separating the retinal tissue from the choroidal space.…”

Section: Discussionmentioning

confidence: 92%

Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

Wang

Teoh

Chan

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 92%

Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

Wang

Teoh

Chan

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Besides in highly myopic eyes, BM defects have been detected intravitally in eyes with a toxoplasmotic retino‐choroidal scar (Oréfice et al. ; Jonas & Panda‐Jonas ). Optical coherence tomographic images showed a collateral localized posterior scleral staphyloma if the toxoplasmotic BM defect was located in the macular region.…”

Section: Discussionmentioning

confidence: 99%

Corrugated Bruch′s membrane in high myopia

Jonas

Ohno‐Matsui

et al. 2017

Acta Ophthalmologica

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Bruch's membrane (BM) corrugation can be present in the vicinity of macular BM defects in highly myopic eyes, perhaps due to differences in the tension within BM in various regions at the margin of the BM defect. Bruch's membrane (BM) corrugation may also develop at the papillary end of BM in eyes with a large parapapillary gamma zone, potentially due to a disinsertion of BM at the end of the peripapillary choroidal border tissue of Jacoby. The observation of BM corrugation may help elucidating the aetiology of axial myopia.

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“…It has been defined as the ectasia of a limited portion of the scleral wall with a radius shorter than the radius of the curvature of the surrounding area [3]. However, PS has also been reported in non-highly myopic eyes [4][5][6]. Due to its close correlation with the causal factors of blindness (i.e., macular hole, myopic retinoschisis, choroidal neovascularization, or retinal detachment), PS has recently been the subject of considerable attention.…”

Section: Introductionmentioning

confidence: 99%

Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

Nie

Ouyang

Tang

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Objective To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). Methods This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters. Results The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, P < 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, P = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, P = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, P = 0.003) and angle α between temporal retinal arterial vascular arcades (113.29°vs 128.39°, P = 0.003), a larger disc tilt ratio (1.41 vs 1.24, P < 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, P = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (P = 0.031) and SFCT (P = 0.015) were significant predictors of PS. In addition, PS (P = 0.049), AL (P = 0.003), corneal refractive power (P < 0.001), ACD (P = 0.022), relative lens position (P = 0.045), and disc area (P = 0.011) were significant predictors of SE. Conclusions PS was found to be closely linked to a reduction in choriocapillaris perfusion and anatomical abnormalities including posterior and anterior segments. Furthermore, PS exacerbated the progression of myopia.

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Secondary Bruch′s membrane defects and scleral staphyloma in toxoplasmosis

Cited by 25 publications

References 11 publications

Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

Biomechanical Properties of Bruch's Membrane–Choroid Complex and Their Influence on Optic Nerve Head Biomechanics

Corrugated Bruch′s membrane in high myopia

Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

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