Secondary Causes of Myositis

Berth, Sarah H.; Lloyd, Thomas E.

doi:10.1007/s11940-020-00646-0

Cited by 6 publications

(4 citation statements)

References 89 publications

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“…According to a systematic review that included 24,410 patients, myalgia was present in 17% [ 157 ]. Muscular injury (defined as the presence of myalgias and CK > 200 U/L) was documented in 10% of hospitalized patients by COVID-19 and some studies have reported increased levels of CK in association with COVID-19 severity [ 158 , 159 ]. The clinical spectrum of muscle damage due to SARS-CoV-2 infection varies from an asymptomatic elevation of CK to severe rhabdomyolysis [ 160 ].…”

Section: Discussionmentioning

confidence: 99%

New Onset of Autoimmune Diseases Following COVID-19 Diagnosis

Gracia‐Ramos

Martín‐Nares

Hernández-Molina

2021

Cells

203

158

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There is growing evidence that coronavirus disease 2019 (COVID-19) can lead to a dysregulation of the immune system with the development of autoimmune phenomena. The consequence of this immune dysregulation ranges from the production of autoantibodies to the onset of rheumatic autoimmune disease. In this context, we conducted a systematic review to analyze the current data regarding the new-onset systemic and rheumatic autoimmune diseases in COVID-19 patients. A literature search in PubMed and Scopus databases from December 2019 to September 2021 identified 99 patients that fulfilled the specific diagnostic/classification criteria and/or nomenclature for each rheumatic autoimmune disease. The main diseases reported were vasculitis and arthritis. Idiopathic inflammatory myopathies, systemic lupus erythematosus, and sarcoidosis were also reported in a limited number of patients, as well as isolated cases of systemic sclerosis and adult-onset Still’s disease. These findings highlight the potential spectrum of systemic and rheumatic autoimmune diseases that could be precipitated by SARS-CoV-2 infection. Complementary studies are needed to discern the link between the SARS-CoV-2 and new onset-rheumatic diseases so that this knowledge can be used in early diagnosis and the most suitable management.

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Section: Discussionmentioning

confidence: 99%

New Onset of Autoimmune Diseases Following COVID-19 Diagnosis

Gracia‐Ramos

Martín‐Nares

Hernández-Molina

2021

Cells

203

158

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“…Transaminitis could originate from myositis rather than liver damage[ 52 ]. Muscular injury [defined as the presence of myalgias and creatinine kinase (CK) > 200 U/L] has been documented in 10% of hospitalized patients by COVID-19 and some studies have reported increased levels of myoglobin of CK in association with COVID-19 severity[ 46 , 53 , 54 ]. Hypoalbuminemia could be explained by decreased hepatic synthesis, malnutrition, increased catabolism, and albumin extravasation because of increased capillary permeability[ 55 , 56 ]; we must recall that hypoalbuminemia is also an acute phase reactant.…”

Section: Sars-cov-2 Infection and Liver Dysfunction In Patients With No Previous Liver Diseasementioning

confidence: 99%

Liver dysfunction and SARS-CoV-2 infection

Gracia‐Ramos¹,

Jáquez-Quintana²,

Contreras-Omaña³

et al. 2021

WJG

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Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019 (COVID-19), which predominantly affects the respiratory system; it also causes systemic and multi-organic disease. Liver damage is among the main extrapulmonary manifestations. COVID-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease, and occurs in approximately one in five patients. Abnormal liver test results have been associated with a more severe course of COVID-19 and other complications, including death. Mechanisms linking COVID-19 to liver injury are diverse. Particular consideration should be made for patients with pre-existing liver disease, such as metabolic dysfunction-associated fatty liver disease, chronic liver disease due to viral or autoimmune disease, liver transplant carriers, or cirrhosis, given the risk for more severe outcomes. This manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology, clinical significance, and management in both patients with or without pre-existing liver disease, to facilitate clinicians’ access to updated information and patient care. Finally, we mention the ideas and recommendations to be considered for future research.

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“…Viral myositis is associated with influenza virus, HIV, and enterovirus infections. Parasitic myositis is associated with Trichinella , Taenia solium , and Toxoplasma gondii [ 5 ]. Autoimmune diseases including polymyositis, dermatomyositis, and inclusion body myositis can also precipitate myositis.…”

Section: Discussionmentioning

confidence: 99%

A 25-Year-Old Military Recruit with Isolated Myositis Following Routine Chemoprophylaxis with Intramuscular Benzathine Penicillin G

Park,

Soderstrom,

Baraki

2023

Am J Case Rep

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Patient: Male, 25-year-old Final Diagnosis: Focal myositis Symptoms: Pain • swelling Clinical Procedure: — Specialty: General and Internal Medicine Objective: Rare coexistence of disease or pathology Background: Myositis is an inflammatory myopathy that can be caused by a variety of drugs, diseases, and toxins. The U.S. military uses chemoprophylaxis with intramuscular penicillin G to prevent group A streptococcal infection. We present a case of penicillin G-induced myositis, a rare cause of drug-induced myositis with limited discussion in the medical literature. Case Report: A 25-year-old man with no pertinent medical history presented to the Emergency Department with right hip and leg pain after receiving a single dose of intramuscular penicillin G as part of standard prophylaxis for group A streptococcal infection during basic military training. He reported pain and leg weakness that was exacerbated by physical exertion and weight bearing but had no systemic symptoms, such as fevers or chills. Initial radiographs of the hip were normal; however, subsequent magnetic resonance imaging of the hip revealed intramuscular edema and features consistent with myositis of the right proximal thigh and hip musculature. He was admitted for isolated right gluteal myositis, attributed to his preceding local penicillin injection. He recovered with symptomatic care over the following 2 weeks, with return to baseline function. Conclusions: This case highlights a rare complication of intramuscular penicillin G as a cause of acute isolated myositis. It serves to inform physicians of this rare complication and to recommend the consideration of intramuscular penicillin G as a causative etiology in individuals presenting with myositis and recent penicillin G exposure.

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Secondary Causes of Myositis

Abstract: Inflammatory myopathy I SARS-CoV-2 I HIV myositis I Immune checkpoint inhibitors I Anti-HMGCR I Malignancy-associated myositis I Overlap myositis I Immunosuppression

Cited by 6 publications

References 89 publications

New Onset of Autoimmune Diseases Following COVID-19 Diagnosis

New Onset of Autoimmune Diseases Following COVID-19 Diagnosis

Liver dysfunction and SARS-CoV-2 infection

A 25-Year-Old Military Recruit with Isolated Myositis Following Routine Chemoprophylaxis with Intramuscular Benzathine Penicillin G

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