The present study evaluates primary-secondary structure interaction (PSSI) in three-dimensional (3D) single- and multi-story steel frame structures. A novel, yet practical, technique was presented to include the effects of secondary systems on the seismic response of coupled structures using concentrated mass systems. Also, a method was proposed to lower the time period of coupled structures via designing a deformable infill wall seating, contrary to the conventional wall-frame connections. The coupled structures were experimentally and numerically studied to examine the effect of secondary systems in the form of concentrated mass, infill walls, and the associated restraining wall posts. Thus, experimental models were exposed to selected ground motion excitations and the finite element (FE) models were subjected to non-linear dynamic time-history analyses. Five types of frame structures were designed, fabricated, and subjected to seismic loading via both approaches and the results were compared. An excellent agreement between the two approaches were observed. It was revealed that secondary systems noticeably increase story displacements and accelerations despite the very light weight, altering the seismic behavior of the entire system. However, free vibrations of the coupled frames were considerably eliminated when the proposed concentrated mass secondary systems were used in steel frames. Also, the input earthquake energy was immediately dissipated in structures with deformable wall seating.