Secondary Degeneration Detected by Combining Voxel-Based Morphometry and Tract-Based Spatial Statistics in Subcortical Strokes with Different Outcomes in Hand Function

Yin, Dazhi; Xu, Yan; Fan, Mingxia; Hu, Ya-Han; Men, Weiwei; Sun, Limin; Song, Fan

doi:10.3174/ajnr.a3410

Cited by 34 publications

(28 citation statements)

References 25 publications

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“…These findings were consistent with previous studies related to subgroups of stroke patients (Yin et al, 2012;Yin, Luo, et al, 2013a;Yin, Yan, et al, 2013b) Corroborating evidence was also documented in several studies between patients and HCs. In addition, the ReHo values in the bilateral CPL were positively correlated with FMA-HW scores, and that in the contralesional SMA was negatively correlated with FMA-HW scores.…”

Section: Full Band Analysis Of Rehosupporting

confidence: 93%

“…In addition, the ReHo values in the bilateral CPL were positively correlated with FMA-HW scores, and that in the contralesional SMA was negatively correlated with FMA-HW scores. These findings were consistent with previous studies related to subgroups of stroke patients (Yin et al, 2012;Yin, Luo, et al, 2013a;Yin, Yan, et al, 2013b Corroborating evidence was also documented in several studies between patients and HCs. Patients with motor conversion disorder showed abnormal activity in the SMA during motor preparation compared to that of normal volunteers (Voon, Brezing, Gallea, & Hallett, 2011).…”

Section: Full Band Analysis Of Rehosupporting

confidence: 93%

“…Nevertheless, the current methods used to assess the recovery of paralyzed hands after stroke are in the preliminary stages. By performing voxel-based morphometric analyses of DTI data, the results demonstrated that the fractional anisotropy (FA) in the CPH group was significantly reduced in the ipsilesional medial frontal gyrus, precentral gyrus, superior temporal gyrus (STG), supplementary motor area (SMA), and contralesional postcentral gyrus (Yin, Yan, et al, 2013b). Specifically, using functional connectivity (FC), we discovered that CPH patients had decreased FC between the ipsilesional primary motor cortex (M1) and the contralesional postcentral gyrus, superior parietal lobule, and ipsilesional inferior parietal lobule (Yin et al, 2012).…”

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confidence: 99%

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Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Zhao

Tang

Yin

et al. 2018

Human Brain Mapping

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Emerging evidence has suggested that abnormalities in regional spontaneous brain activity following stroke may be detected by intrinsic low-frequency oscillations (LFO) in resting-state functional MRI (R-fMRI). However, the relationship between hand function outcomes following stroke and local LFO synchronization in different frequency bands is poorly understood. In this study, we performed R-fMRI to examine the regional homogeneity (ReHo) at three different frequency bands (slow-5: .01-.027 Hz; slow-4: .027-.08 Hz; and typical band: .01-.1 Hz) in 26 stroke patients with completely paralyzed hands (CPH) and 26 matched patients with partially paralyzed hands (PPH). Compared to the PPH group, decreased ReHo in the bilateral cerebellum posterior lobes and the contralesional cerebellum anterior lobe was observed in the slow-5 band and the slow-4 band in the CPH group, respectively. The mean ReHo values in these regions were positively correlated with the Fugl-Meyer assessment (FMA) scores. In contrast, increased ReHo in the contralesional supplementary motor area and the contralesional superior temporal gyrus was observed in the slow-4 band and the slow-5 band, respectively. The mean ReHo values in these regions were negatively correlated with the FMA scores. Importantly, significant interactions were identified between the frequency bands and the subgroups of patients in the contralesional precentral gyrus and middle frontal gyrus. These findings indicate that frequency-dependent R-fMRI patterns may serve as potential biomarkers of the neural substrates associated with hand function outcomes following stroke.

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Section: Full Band Analysis Of Rehosupporting

confidence: 93%

Section: Full Band Analysis Of Rehosupporting

confidence: 93%

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confidence: 99%

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Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Zhao

Tang

Yin

et al. 2018

Human Brain Mapping

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“…Recently this method has been applied to evaluate white-matter changes of schizophrenia [10, 11] and Parkinson's disease [12]. Yet, few studies have reported stroke-related changes in the WM structural networks using TBSS [13–15]. Most of these studies mirrored lesion in one hemisphere to another across the midsagittal axis.…”

Section: Introductionmentioning

confidence: 99%

“…However, this method does not use a symmetric cerebral template and may cause unreliable results. Only one study did not adopt mirror about midline due to enrolling lesions in the same hemisphere [15]. However the lesion locations are not in accordance with clinical practice and greatly limit the subject sample.…”

Section: Introductionmentioning

confidence: 99%

Fully Automated Detection of Corticospinal Tract Damage in Chronic Stroke Patients

Yang

et al. 2014

Computational and Mathematical Methods in Medicine

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Structural integrity of the corticospinal tract (CST) after stroke is closely linked to the degree of motor impairment. However, current methods for measurement of fractional atrophy (FA) of CST based on region of interest (ROI) are time-consuming and open to bias. Here, we used tract-based spatial statistics (TBSS) together with a CST template with healthy volunteers to quantify structural integrity of CST automatically. Two groups of patients after ischemic stroke were enrolled, group 1 (10 patients, 7 men, and Fugl-Meyer assessment (FMA) scores ⩽ 50) and group 2 (12 patients, 12 men, and FMA scores = 100). CST of FAipsi, FAcontra, and FAratio was compared between the two groups. Relative to group 2, FA was decreased in group 1 in the ipsilesional CST (P < 0.01), as well as the FAratio (P < 0.01). There was no significant difference between the two subgroups in the contralesional CST (P = 0.23). Compared with contralesional CST, FA of ipsilesional CST decreased in group 1 (P < 0.01). These results suggest that the automated method used in our study could detect a surrogate biomarker to quantify the CST after stroke, which would facilitate implementation of clinical practice.

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Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke

Lu,

Xing,

et al. 2024

Brain and Behavior

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BackgroundThe volumes of the hippocampal subfields are related to poststroke cognitive dysfunctions. However, it remains unclear whether contralesional hippocampal subfield volume contributes to cognitive impairment. This study aimed to investigate the volumetric differences in the contralesional hippocampal subfields between patients with left and right hemisphere strokes (LHS/RHS). Additionally, correlations between contralesional hippocampal subfield volumes and clinical outcomes were explored.MethodsFourteen LHS (13 males, 52.57 ± 7.10 years), 13 RHS (11 males, 51.23 ± 15.23 years), and 18 healthy controls (11 males, 46.94 ± 12.74 years) were enrolled. Contralesional global and regional hippocampal volumes were obtained with T1‐weighted images. Correlations between contralesional hippocampal subfield volumes and clinical outcomes, including the Montreal Cognitive Assessment (MoCA) and Mini‐Mental State Examination (MMSE), were analyzed. Bonferroni correction was applied for multiple comparisons.ResultsSignificant reductions were found in contralesional hippocampal as a whole (adjusted p = .011) and its subfield volumes, including the hippocampal tail (adjusted p = .005), cornu ammonis 1 (CA1) (adjusted p = .002), molecular layer (ML) (adjusted p = .004), granule cell and ML of the dentate gyrus (GC‐ML‐DG) (adjusted p = .015), CA3 (adjusted p = .009), and CA4 (adjusted p = .014) in the RHS group compared to the LHS group. MoCA and MMSE had positive correlations with volumes of contralesional hippocampal tail (p = .015, r = .771; p = .017, r = .763) and fimbria (p = .020, r = .750; p = .019, r = .753) in the LHS group, and CA3 (p = .007, r = .857; p = .009, r = .838) in the RHS group, respectively.ConclusionUnilateral stroke caused volumetric differences in different hippocampal subfields contralesionally, which correlated to cognitive impairment. RHS leads to greater volumetric reduction in the whole contralesional hippocampus and specific subfields (hippocampal tail, CA1, ML, GC‐ML‐DG, CA3, and CA4) compared to LHS. These changes are correlated with cognitive impairments, potentially due to disrupted neural pathways and interhemispheric communication.

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Secondary Degeneration Detected by Combining Voxel-Based Morphometry and Tract-Based Spatial Statistics in Subcortical Strokes with Different Outcomes in Hand Function

Cited by 34 publications

References 25 publications

Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Frequency‐specific alterations of regional homogeneity in subcortical stroke patients with different outcomes in hand function

Fully Automated Detection of Corticospinal Tract Damage in Chronic Stroke Patients

Alterations of contralesional hippocampal subfield volumes and relations to cognitive functions in patients with unilateral stroke

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