Secondary delayed type hypersensitivity to sheep red blood cells in mice: Dependence on long-lived memory cells

Kwast, Theodorus H. van der; Olthof, Johanna G.; Ruiter, H. de; Benner, R.

doi:10.1016/0008-8749(79)90153-9

Cited by 11 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DTH response depends entirely on the presence of previously activated T cells in the challenged tissue and is an indication for the efficiency of the immune system to establish a long-lasting Ag-specific T cell response (33). A positive DTH response to Leishmania Ag is induced early after infection with L. major parasites (34).…”

Section: Figure 6 Mice Depleted For Langerinmentioning

confidence: 99%

Priming of CD8+ and CD4+ T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes

Brewig

Kissenpfennig

Malissen

et al. 2009

The Journal of Immunology

View full text Add to dashboard Cite

The biological role of Langerin+ dendritic cells (DCs) such as Langerhans cells and a subset of dermal DCs (dDCs) in adaptive immunity against cutaneous pathogens remains enigmatic. Thus, we analyzed the impact of Langerin+ DCs in adaptive T cell-mediated immunity toward Leishmania major parasites in a Lang-DTR mouse model that allows conditional diphtheria toxin (DT)-induced ablation of Langerin+ DCs in vivo. For the first time, infection experiments with DT-treated Lang-DTR mice revealed that proliferation of L. major-specific CD8+ T cells is significantly reduced during the early phase of the immune response following depletion of Langerin+ DCs. Consequently, the total number of activated CD8+ T cells within the draining lymph node and at the site of infection is diminished. Furthermore, we show that the impaired CD8+ T cell response is due to the absence of Langerin+ dDCs and not Langerhans cells. Nevertheless, the CD4+ T cell response is not altered and the infection is cleared as effectively in DT-treated Lang-DTR mice as in control mice. This clearly demonstrates that Langerin+ DCs are, in general, dispensable for an efficient adaptive immune response against L. major parasites. Thus, we propose a novel concept that, in the experimental model of leishmaniasis, priming of CD4+ T cells is mediated by Langerin− dDCs, whereas Langerin+ dDCs are involved in early priming of CD8+ T cells.

show abstract

Section: Figure 6 Mice Depleted For Langerinmentioning

confidence: 99%

Priming of CD8+ and CD4+ T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes

Brewig

Kissenpfennig

Malissen

et al. 2009

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…After re-infection with L. major parasites C57BL/6 CCR6 À/À mice showed a statistically enhanced and prolonged footpad swelling compared to C57BL/6 WT mice. The generation of both a DTH-reaction and resistance to re-infection depends on the presence of antigen-specific memory T cells [27,41] that are able to enter the peripheral tissue at the site of antigen challenge quickly [42]. Because both responses are deficient or slowed in CCR6-deficient mice this receptor might be involved in the differentiation of T cells along the pathway to effector and memory T cells in experimental murine leishmaniasis.…”

Section: Discussionmentioning

confidence: 99%

“…The DTH response depends entirely on the presence of previously activated T cells in the challenged tissue [27] and is an indication for the efficacy of the immune system to establish a long-lasting antigen-specific T-cell response. Therefore, 3 weeks after infection we injected L. major antigen into the right fore-footpad of L. major-infected C57BL/6 CCR6 À/À and WT mice.…”

Section: Activation Of T Cells In L Major Infection: Phenotypical Anmentioning

confidence: 99%

Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice

Lechner

Ritter

Varona

et al. 2007

Microbes and Infection

View full text Add to dashboard Cite

“…A/J mice were used here to study the effects of aging on Arthus and tuberculin-type [van der Kwast et al, 1979] hypersensitivi ties, because they are a familiar, readily avail able strain with a medium life span [Goodrick, 1975] in which age-related changes in several other kinds of immunologic response have been characterized [Adler ct al., 1978;Rodeyet al, 1971;Teaguet1 al.. 1970]. They die of random causes during aging like most other strains of mice [Friou and Teague.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aging in A/J Mice on Delayed and Arthus Hypersensitivities, Anamnesis and a Low-Dose Tolerance

Crowle¹,

Miller²,

Grove³

1981

Gerontology

View full text Add to dashboard Cite

This paper describes a 2-year experiment on the flux with aging in A/Jax female mice of Arthus and tuberculin-type delayed hypersensitivities to chicken conalbumin antigen, of delayed hypersensitivity to methylated human serum albumin antigen, of anamnestic responses for these phenomena, and of a low-dose tolerance. The mice began to lose ability to develop delayed hypersensitivity at 15–18 months of age, or 0.6–0.7 mean life span. They retained ability to develop Arthus hypersensitivity, general anamnestic responsiveness, a capacity to develop low-dose tolerance preventing primary induction of delayed hypersensitivity and, once sensitized, the ability to express delayed hypersensitivity reactions well into senescence ( > 0.8 mean life span). These findings agree generally with most others on age-related flux of immunologic responses in mice and man, that cell-mediated responses are shorter-lived than humoral responses, and that induction (primary responsiveness) is much more affected than reaction or anamnesis (secondary responsiveness). Retention with aging of a capacity to develop tolerance, apparently not previously studied, could be important in explaining flagging primary responsiveness, because this (i.e. induction) is what such tolerance suppresses. Thus, certain unanticipated aspects of the experiment reported here suggest that accumulated exposure to food antigens may have contributed to age-related (i.e. time-related) decline of immunologic responses by progressive induction of such tolerance. The simple experimental model described here should be useful for investigating this possibility and the interplay of positive and negative immunologic responses with particular relevance to understanding such effects in aging human beings, since it studies natural changes in whole mice but with greater control, speed and dissectability that could ever be possible in man.

show abstract

Secondary delayed type hypersensitivity to sheep red blood cells in mice: Dependence on long-lived memory cells

Cited by 11 publications

References 26 publications

Priming of CD8+ and CD4+ T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes

Priming of CD8+ and CD4+ T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes

Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice

Effects of Aging in A/J Mice on Delayed and Arthus Hypersensitivities, Anamnesis and a Low-Dose Tolerance

Contact Info

Product

Resources

About