Secondary Diabetic Retinopathy in Chronic Pancreatitis

Maekawa, Nobuo; Ohneda, Akira; Kai, Yasuyuki; Saito, Yoichi; Koseki, Sen

doi:10.1016/s0002-9394(14)78114-0

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…These findings supported the view proposed by Sprague (1947) and Deckert (1960). Regarding the severity of diabetic retinopathy, the prevalence of severe retinopathy (i.e., proliferative retinopathy) in patients with pancreatic diabetes has been reported to be low (Maekawa et al 1978;Mohan et al 1985). In the present study, however, rapid progression of retinopathy was observed even in patients in whom calcifying pancreatitis was detected earlier than diabetes.…”

Section: Discussionsupporting

confidence: 93%

“…diabetes began to attract attention, and the prevalence and characteristics of retinopathy have been studied in many cases of pancreatic diabetes (Maekawa et al 1978; Tiengo et al 1983; Couet et al 1985; Mohan et al 1985).…”

mentioning

confidence: 99%

“…In Japan, however, such reports are few (Maekawa et al 1978). Therefore, we analyzed the prevalence, aggravating factors and characteristics of diabetic retinopathy in patients with long-standing pancreatic diabetes in order to obtain a clear view of diabetic microangiopathy in cases of pancreatic diabetes.…”

mentioning

confidence: 99%

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Diabetic Retinopathy in Japanese Patients with Long-Standing Pancreatic Diabetes Due to Calcifying Pancreatitis.

Nakamura

Imamura

Takebe

et al. 1994

Tohoku J. Exp. Med.

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This study analyzed the prevalence, aggravating factors (including duration of diabetes, glycemic control, body mass index, hypertension, serum total cholesterol, changes of ST on ECG and diabetic therapies) and characteristics of diabetic retinopathy in 75 patients with pancreatic diabetes resulting from calcifying pancreatitis. The patients were divided into three Groups: Group I (27 patients in whom diabetes was detected earlier than pancreatic stones), Group II (36 patients in whom diabetes and pancreatic stones were simultaneously detected) and Group III (12 patients in whom pancreatic stones were detected earlier than diabetes). The prevalence of retinopathy was dependent on the duration of diabetes as well as poor glycemic control. It was significantly (p <0.01) higher among the patient with the duration of diabetes that was more than 5 years than that of the patients whose duration was less than 5 years. The prevalence of retinopathy in Group I (63%) was significantly (p <0.05) higher than that in Group 11 (30.6%) and Group III (12.5%). Proliferative retinopathy was not found in any patients with a duration of diabetes less than 5 years, while it was found in 5 patients with a duration of more than 5 years (5 cases out of 31 patients). Diabetic retinopathy was correlated with the duration of diabetes and glycemic control, and was not linked to frequency of hypoglycemia and family history of diabetes. From the results above, we concluded that diabetic retinopathy in patients with pancreatic diabetes due to calcifying pancreatitis might be taken as evidence that such complications are primarily due to chronic hyperglycemia and the duration of diabetes mellitus rather than to genetic factors and other factors (body mass index, hypertension, serum total cholesterol and diabetic therapies). diabetic retinopathy; pancreatic diabetes; duration of diabetes; chronic hyperglycemia; calcifying pancreatitisIn the past, the prevalence of complication by diabetic retinopathy in patients with pancreatic diabetes was thought to be low (Sevel et al. 1971). However, after Sprague reported the complication of pancreatic diabetes (microangiopathy) in 1947 (Sprague 1947), microangiopathy in patients with pancreatic

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

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Diabetic Retinopathy in Japanese Patients with Long-Standing Pancreatic Diabetes Due to Calcifying Pancreatitis.

Nakamura

Imamura

Takebe

et al. 1994

Tohoku J. Exp. Med.

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“…Initial studies showed that diabetic retinopathy is a rare complication of pancreatic diabetes, occurring in 7.4-18% of cases [53,54] . However, comparison of the incidence of this complication in patients with type 1 diabetes with a group of CP patients indicated no difference in the risk for retinopathy in these two groups; the duration of known diabetes was on average 6.6 years, that is, similar to that in the fi rst group [55] .…”

Section: Differences Between Pancreatic and Idiopathic Diabetesmentioning

confidence: 99%

Endocrine pancreatic insufficiency in chronic pancreatitis

Angelopoulos¹,

Dervenis

Goula

et al. 2005

Pancreatology

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“…Whether the diabetes associated with chronic pancre atitis carries the increased risk of vascular disease is controversial [221,[228][229][230]. While most studies suggest that patients with secondary diabetes are spared from signifi cant retinopathy [231], this may be an arti fact of shorter duration of hyperglycemia. Lipid malabsorption or altered lipid metabo lism, associated with pancreatic exocrine in sufficiency [232], may protect these patients from the vascular complications.…”

Section: The Biliary Tractmentioning

confidence: 99%