Secondary Fibromyalgia

Bennett, Robert M.; Friend, Ronald

doi:10.3899/jrheum.180611

Cited by 11 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both forms impact either the associated or the co-morbid disease outcomes and treatment strategies. 10 Chronic pain is the prominent feature of OA and FM. Additionally, they share the central sensitization mechanism of pain transmission which is a pain perception mechanism concerned with chronic pain development and maintenance.…”

Section: Introductionmentioning

confidence: 99%

<p>Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life</p>

Mahgoub

Elnady

Abdelkader

et al. 2020

OARRR

View full text Add to dashboard Cite

Background: Knee osteoarthritis (OA) is a painful condition with peripheral and central pain transmission. Fibromyalgia (FM) is the role model of central sensitization of pain perception. Aim: To assess the frequency of FM in knee OA patients and evaluate the impact of FM on mental health and the quality of life in knee OA patients. Patients and Methods: A total of 121 female patients were recruited and divided into 3 groups: group I of 59 patients with knee OA only, group II of 32 patients with knee OA and FM, and group III of 30 FM patients. Patients underwent history taking, examination, investigations, and radiological evaluation of both knees. The assessment of visual analog scale (VAS), Pittsburgh Sleep Quality Index (PSQI), Pain Anxiety Symptom Scale Short Form 20 (PASS20), Beck Depression Inventory (BDI-II), and PCASEE questionnaire were done for all patients. Lequesne index of knee OA and radiological Kellgren and Lawrence score severity were done for all OA patients. Fibromyalgia Impact Questionnaire (FIQ) was assessed for all FM patients. Results: FM was diagnosed in 35.5% of knee OA patients. Group II patients had higher VAS, PASS-20, PSQI, and lower quality of life than either groups I and III, elevated Lequesne index score than group I, significant correlation between VAS and BMI (p=0.002), Lequesne index score (p<0.001), PASS20 (p=0.006), BDI-II score (p=0.002), and FIQ (P<0.001), and a negative correlation was found between VAS and physical (p<0.001), anxiety (p=0.046), and social (p=0.026) QoL parameters. Univariable regression analysis showed a higher age, VAS, PSQI, PASS20, and FIQ were associated with lower QoL in group II. A higher PASS20 was the only predictor of lower QoL in multivariable analysis. Conclusion: Fibromyalgia coexists frequently in knee OA patients and has implications on their mental health, functional activity, and quality of life.

show abstract

Section: Introductionmentioning

confidence: 99%

<p>Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life</p>

Mahgoub

Elnady

Abdelkader

et al. 2020

OARRR

View full text Add to dashboard Cite

show abstract

“…Serologic studies, like antinuclear antibody, rheumatoid factor assays, complement proteins, or enzyme-linked immunosorbent assay test (Lyme disease), are generally avoided unless risk factors or certain signs or symptoms are present (for example, prolonged joint stiffness, synovitis, family history of autoimmune disorder, history of tick bites). Imaging studies, such as radiography, ultrasound, computed tomography, and MRI depend upon subjective and objective findings, previous imaging findings (if applicable), and past or recent trauma or surgeries 9…”

Section: Diagnosing Fibromyalgia: Rule In (Not Out)mentioning

confidence: 99%

Fibromyalgia

John

Aebischer

Friend

et al. 2022

The Nurse Practitioner

Self Cite

View full text Add to dashboard Cite

show abstract

“… 3 It can be associated with other clinical entities including migraine, irritable bowel syndrome, and depression. 13 …”

Section: Juvenile Fibromyalgiamentioning

confidence: 99%

“… 40 Fibromyalgia, on the other hand, has been conventionally considered as a primary idiopathic syndrome, often associated with other clinical entities such as irritable bowel syndrome, migraine headaches, and depression. 13 …”

Section: Moving Forwardmentioning

confidence: 99%

Implications of Nerve Fiber Density on the Diagnosis and Treatment of Juvenile Fibromyalgia

Ahmed¹,

Vigouroux²,

Ingelmo³

2022

JPR

View full text Add to dashboard Cite

Juvenile fibromyalgia (JFM) is a condition that presents as chronic widespread musculoskeletal pain and affects children and adolescents. JFM remains a challenging diagnosis, as it is both based on subjective criteria and the pathogenesis is poorly understood. Small fiber neuropathy (SFN) is a distinct condition, which is characterized by pathology of small A-delta and C fibers, and can present similarly to JFM. Small fiber pathology is characterized by reduced intraepidermal nerve fiber density (IENFD) on skin biopsy. Recent studies have found that as many as half of patients with JFM can demonstrate decreased IENFD, in pattern similar to SFN. This phenomenon has been referred to as small fiber pathology. The meaning of these findings was disputed; however, the current consensus remains that fibromyalgia and SFN are distinct conditions. Additionally, among patients with fibromyalgia, there are two phenotypes: those with small fiber pathology and those without. The purpose of this review was to characterize the role assessment of IENFD plays in the clinical context. We conducted a narrative review of pertinent articles pertaining to JFM, SFN and small fiber pathology in fibromyalgia. We concluded that assessment of IENFD should be completed if SFN is suspected either when a patient first presents or in patients who were previously diagnosed with fibromyalgia and SFN is later suspected. Distinguishing between JFM and SFN is important because recommended therapies differ between the two conditions. However, there is no evidence to support the use of skin biopsy to distinguish between the two discussed fibromyalgia phenotypes. More studies are needed to elucidate whether IENFD varies with morbidity and if both fibromyalgia phenotypes vary in their response to different therapeutic regimens.

show abstract

Secondary Fibromyalgia

Cited by 11 publications

References 16 publications

<p>Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life</p>

<p>Comorbidity of Fibromyalgia in Primary Knee Osteoarthritis: Potential Impact on Functional Status and Quality of Life</p>

Fibromyalgia

Implications of Nerve Fiber Density on the Diagnosis and Treatment of Juvenile Fibromyalgia

Contact Info

Product

Resources

About