Secondary headaches: secondary or still primary?

Schankin, Christoph; Straube, Andreas

doi:10.1007/s10194-012-0443-8

Cited by 30 publications

(20 citation statements)

References 59 publications

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“…Pre-existing primary headache disorder is a demodulatory pain process (25), where derangement of top-down pain modulatory pathways occurs with atypical release of nociceptive molecules (26). Such alterations can lead to sensitization of central and peripheral nociceptive pathways resulting in a decrease in the pain threshold and an increase in receptive fields (27,28). Specifically for migraine, cortical spreading depression (CSD) may add to hyperexcitability of the trigeminovascular neurons (29).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross sectional study

et al. 2020

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Objective To study the characteristics of headache attributed to COVID-19 infection and predictors of its severity. Methods A cross-sectional study involved 172 individuals who had headache due to COVID-19 infection. A detailed analysis of such headache was done through a face-to-face interview. Patients with any other form of secondary headache were excluded. Labs, including lymphocytic count, C-reactive protein, D-dimer and ferritin and chest imaging, were made available. Results: The majority of our patients had a diffuse headache (52.9%). It was pressing in 40.7%, with median intensity of 7 (assessed by visual analogue scale) and median frequency of 7 days/week. Patients with preexisting primary headache (52.9%) had significantly more frequent COVID-19 related headache than those without (47.1%) ( p = 0.001). Dehydrated patients (64.5%) had more frequent COVID-19 related headache than those who were not dehydrated (35.5%) ( p = 0.029). Patients with fever (69.8%) had significantly higher frequency and intensity of COVID-19 related headache compared to those without fever (30.2%) ( p = 0.003, 0.012). Patients with comorbidities (19.8%) had significantly higher frequency and intensity of headache than those without comorbidities (80.2%) ( p = 0.006, 0.003). After multiple linear regression, primary headache disorders, dehydration and comorbidities were considered predictors of frequency of COVID-19 related headache. Meanwhile, fever and dehydration were predictors of pain intensity. Conclusion Healthcare providers of COVID-19 patients need to be aware of frequency and intensity predictors of COVID-19 related headache: Primary headache disorders, fever, dehydration, and comorbidities.

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Section: Discussionmentioning

confidence: 99%

Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross sectional study

et al. 2020

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“…One study found that progression of tumor edema was associated with headache progression . The fact that brain tumor headaches can present similarly to primary headaches in those with a predisposition to headaches suggests a shared pathophysiology between primary and tumor‐related headaches …”

Section: Brain Tumor Headache In General and The Ichdmentioning

confidence: 99%

Headaches in Brain Tumor Patients: Primary or Secondary?

Nelson

Taylor

2014

Headache

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Our literature review revealed that brain tumor headache uncommonly presents with classic brain tumor headache characteristics and often satisfies criteria for a primary headache category such as migraine or tension-type. Thus, clinicians may miss headaches due to brain tumors in following ICHD-3 criteria, and the distinction between primary and secondary headache disorders may not be so clear-cut.

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“…The Brain Tumour Headache (BTH) is classically described as progressive, worse in the morning and aggravated by Valsalva-like manoeuvres; however, its clinical features are not so specific and sometimes satisfy the criteria for primary headache such as migraine or tension-type headache (3,4,9,10).…”

Section: Introductionmentioning

confidence: 99%

Headache as a presenting symptom of glioma: A cross-sectional study

Russo

Villani²,

Taga

et al. 2017

Cephalalgia

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Objective The objective of this study was to analyse the prevalence and the clinical features of headache as a presenting symptom of glioma. Methods We interviewed 527 consecutive adult patients with histologically confirmed glioma, admitted to the Regina Elena National Cancer Institute between 2010 and 2015. We defined four headache phenotypes: Tension-type-like headache (TTH), migraine-like headache, worsening of a pre-existing headache (WPH) and classic brain tumour headache (BTH). Logistic regression analysis was carried out to investigate potential risk factors for headache at presentation of glioma. Results 12.5% (n = 66) of patients with glioma indicated headache as a presenting symptom of their disease. Of these, 31 patients (47%) had TTH, while BTH and WPH were reported by 28 (42%) and seven (11%) patients, respectively. We did not find any case of migraine-like headache. Infratentorial ( p = 0.038) and right-sided tumours ( p = 0.013) were more frequently associated with the presence of headache at onset. Patients with TTH were older than patients with BTH and WPH ( p = 0.035). BTH was less frequently associated with other neurological signs ( p < 0.0001). The multivariate logistic regression analysis showed the localization of the brain tumour in the left hemisphere to be a protective factor for the development of headache. Conclusions Our study includes a very large series of patients with glioma, providing a description of headache phenotype at first presentation of disease and investigating possible factors that may influence the clinical features of headache.

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Secondary headaches: secondary or still primary?

Cited by 30 publications

References 59 publications

Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross sectional study

Characteristics of headache attributed to COVID-19 infection and predictors of its frequency and intensity: A cross sectional study

Headaches in Brain Tumor Patients: Primary or Secondary?

Headache as a presenting symptom of glioma: A cross-sectional study

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