Secondary hyperparathyroidism prevalence and prognostic role in elderly males with heart failure

Loncar, Goran; Božić, Biljana; Cvetinovic, Nataša; Düngen, Hans‐Dirk; Lainščak, Mitja; Haehling, S. von; Doehner, Wolfram; Radojičić, Zoran; Putniković, Biljana; Trippel, Tobias Daniel; Popović, Vera

doi:10.1007/s40618-016-0561-2

Cited by 17 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients with HF had higher rates of PTH, irrespectively of its etiology what remains in line with previously published studies [ 23 – 27 ]. PTH concentration in HF correlates with disease severity, expressed by decreased LVEF, increased EDV, and functional NYHA class.…”

Section: Discussionsupporting

confidence: 91%

“…VDD combined with raised PTH represents a vicious cycle of mechanisms on one hand leading to HF and in the other hand worsening the prognosis of HF. It is worth to mention that myocardial fibrosis and hypertrophy, excessive adrenergic stimulation, calcium cell overload, oxidative stress enhancement, and FGF-23 formation have huge impact on impaired survival [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases

et al. 2018

View full text Add to dashboard Cite

25-hydroxyvitamin D (25(OH)D) plays a crucial role in human homeostasis. Its deficiency (vitamin D deficiency—VDD), being common in European population, combined with elevated concentration of parathyroid hormone (PTH), represents a vicious cycle of mechanisms leading to heart failure (HF). Despite several papers published in that field, the effect of VDD and PTH concentration on cardiovascular system remains unequivocal; thus, the aim of the study was to compare these data among HF and non-HF patients being prospectively enrolled into the study during hospital stay in the cardiology ward. Patients with HF had higher PTH concentration (85.0 ± 52.6 versus 64.5 ± 31.7, p ≤ 0.02) compared to non-HF patients. Mean PTH values were associated with the clinical status expressed by the New York Heart Association class (NYHA class) (“0”—66.04, “I”—56.57, “II”—72.30, “III”—85.59, and “IV”—144.37 pg/ml, p ≤ 0.00004). Interestingly, neither 25(OH)D (31.5 versus 29.7 ng/ml, p ≤ ns) nor phosphorus (P) (1.23 versus 1.18 mmol/l, p ≤ ns) nor total calcium (Ca2+) concentration (2.33 versus 2.37 mmol/l, p ≤ ns) differed among the groups. Reassuming PTH serum concentration in contrary to 25(OH)D, P and Ca2+ are significantly raised among the patients with HF and shows significant relationship with the clinical status expressed by the NYHA class.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Patients with insufficiency cardiac and secondary hyperparathyroidism had more severe myocardial dysfunction compared with those with normal serum PTH, and determination of serum PTH levels provided additional value to NT-proBNP for risk stratification in these patients. 48 In a recent prospective study, correcting vitamin D deficiency in HD patients in associated with better secondary hyperparathyroidism control with lower doses of vitamin D analogues, as well as an improvement in inflammatory status. 49 All patients in this study underwent a Doppler echocardiography; and left ventricular hypertrophy changes and reduced left ventricular function seen by this method were associated with vitamin D deficiency, demonstrating the importance of this examination, because the changes of the structure and cardiac function in elderly are usually subclinical, and these often precede the development of HF.…”

Section: Discussionmentioning

confidence: 99%

Association between vitamin D deficiency and heart failure risk in the elderly

Porto

Silva

Luz³

et al. 2017

ESC Heart Failure

View full text Add to dashboard Cite

AimsThe aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics.Methods and resultsA cross‐sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia. To analyse the association between vitamin D deficiency and risk of heart failure, we used the bivariate logistic analysis, followed by analysis through the multivariate logistic regression model. Of the 137 elderly, the study found the following: women (75.9%); overweight (48.2%); obese (30.6%); increase in the index waist/hip (88.3%); dyslipidaemia (94.2%) and hypertension (91.2%); coronary artery disease (35.0%); and 27.7% with cardiac arrhythmia or left ventricular hypertrophy. Sixty‐five per cent of the elderly were deficient in vitamin D. The risk of heart failure was significantly associated with vitamin D deficiency [odds ratio (OR): 12.19; 95% confidence interval (CI) = 4.23–35.16; P = 0.000], male gender (OR: 15.32; 95% CI = 3.39–69.20, P = 0.000), obesity (OR: 4.17; 95% CI = 1.36–12.81; P = 0.012), and cardiac arrhythmia (OR: 3.69; 95% CI = 1.23–11.11; P = 0.020).ConclusionsThere was a high prevalence of vitamin D deficiency in the elderly, and the evidence shows a strong association between vitamin D deficiency and increased risk of heart failure in this population.

show abstract

“…These studies suggest severe hypocalcemia associated with rickets in infants and hypoparathyroidism as causes of DCM, cardiac remodeling, HF, and impaired cardiac function. Improvement in clinical symptoms after vitamin D and calcium supplementation for the treatment of hypovitaminosis and hypocalcemia signifies the importance and protective role of vitamin D in cardiomyopathy [9–10, 34–39] (Table 1). Gruson et al [40] suggested that serum 1,25(OH) 2 D 3 and its ratio to parathyroid hormone (PTH) (1–84) strongly and independently predict cardiovascular mortality in chronic HF.…”

Section: Cardiac Diseasesmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

View full text Add to dashboard Cite

Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

show abstract

Secondary hyperparathyroidism prevalence and prognostic role in elderly males with heart failure

Cited by 17 publications

References 41 publications

The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases

The Role of Parathyroid Hormone and Vitamin D Serum Concentrations in Patients with Cardiovascular Diseases

Association between vitamin D deficiency and heart failure risk in the elderly

Role of Vitamin D in Cardiovascular Diseases

Contact Info

Product

Resources

About